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The map label for this gene is purC

Identifier: 195977179

GI number: 195977179

Start: 31193

End: 31903

Strand: Direct

Name: purC

Synonym: Sez_0023

Alternate gene names: 195977179

Gene position: 31193-31903 (Clockwise)

Preceding gene: 195977178

Following gene: 195977180

Centisome position: 1.54

GC content: 40.65

Gene sequence:

>711_bases
GTGTCTAATCAACTCATTTATTCAGGTAAGGCAAAGGATATCTATGAAACAGCCGATGACGGGATTGTCTTAATCTCCTA
CAAGGATCAGGTCACTATGCTAAATGGAGCACATAAGGAAATGATTGAAGGAAAAGGGAGCCTTAATAATCAGATTTCTG
CCTTAATCTTTGATAGGCTAAATAGGGTTGGCGTATCAACTCATTTTATTAAGCAATTATCCGAGACAGAACAGTTAAAT
AAAAGGGTTGCGATTATTCCTTTGGAGGTTGTTTTACGAAACGTGGCCGCTGGCTCATTTTCAAAGCGCTTTGGTGTTAA
AGAAGGTCAGGCTTTGGACGAGCCAATTATTGAGCTTTATTACAAGAATGACGCTTTAGATGATCCTTTCATTAATGATG
AGCATGTCAGCTTTTTAAAGCTTGCGACTGATGAGCAGATAGCCTACATCAAACAAGAGACGCATCGTATTAATGCTTAT
TTGAAGGAGTGGTTTGCTAGTGTTGGGTTGACACTGGTTGATTTTAAGCTAGAATTTGGCTTTGATAAGGAGGGGATGCT
TATCCTTGCTGATGAGTTTTCTCCGGATAATTGCCGCTTGTGGGATAATGCGGGCCGTCACATGGATAAGGACGTTTTTC
GTCGTCAGCTTGGCAGTTTGACGCAAGCCTATGAGACTGTTTTAGAAAGGCTAAGAGCATTGGATCAATAA

Upstream 100 bases:

>100_bases
ATTATAAGTTTATTTTATATTAAATGTAAATAAATGTTGAATATTTAGTATGTTTGTGGTATTGTTTAGATATTAAATGC
AAAGAAAGGCGAACAAATAA

Downstream 100 bases:

>100_bases
AGACCAGCTTATTTGTTGTCAGTTAAGAAAGGGAGCTCTTTTTTGTCCGTCATGTAAGAAAATAAATCAGTTCAGACTAT
TTGAGCTGCTGTCTAAGAAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSNQLIYSGKAKDIYETADDGIVLISYKDQVTMLNGAHKEMIEGKGSLNNQISALIFDRLNRVGVSTHFIKQLSETEQLN
KRVAIIPLEVVLRNVAAGSFSKRFGVKEGQALDEPIIELYYKNDALDDPFINDEHVSFLKLATDEQIAYIKQETHRINAY
LKEWFASVGLTLVDFKLEFGFDKEGMLILADEFSPDNCRLWDNAGRHMDKDVFRRQLGSLTQAYETVLERLRALDQ

Sequences:

>Translated_236_residues
MSNQLIYSGKAKDIYETADDGIVLISYKDQVTMLNGAHKEMIEGKGSLNNQISALIFDRLNRVGVSTHFIKQLSETEQLN
KRVAIIPLEVVLRNVAAGSFSKRFGVKEGQALDEPIIELYYKNDALDDPFINDEHVSFLKLATDEQIAYIKQETHRINAY
LKEWFASVGLTLVDFKLEFGFDKEGMLILADEFSPDNCRLWDNAGRHMDKDVFRRQLGSLTQAYETVLERLRALDQ
>Mature_235_residues
SNQLIYSGKAKDIYETADDGIVLISYKDQVTMLNGAHKEMIEGKGSLNNQISALIFDRLNRVGVSTHFIKQLSETEQLNK
RVAIIPLEVVLRNVAAGSFSKRFGVKEGQALDEPIIELYYKNDALDDPFINDEHVSFLKLATDEQIAYIKQETHRINAYL
KEWFASVGLTLVDFKLEFGFDKEGMLILADEFSPDNCRLWDNAGRHMDKDVFRRQLGSLTQAYETVLERLRALDQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=249, Percent_Identity=35.3413654618474, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI5453539, Length=249, Percent_Identity=35.3413654618474, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI119220559, Length=256, Percent_Identity=34.375, Blast_Score=124, Evalue=6e-29,
Organism=Escherichia coli, GI1788820, Length=227, Percent_Identity=41.8502202643172, Blast_Score=190, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17531275, Length=221, Percent_Identity=36.1990950226244, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319326, Length=239, Percent_Identity=25.9414225941423, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI18860083, Length=230, Percent_Identity=29.5652173913043, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583917, Length=249, Percent_Identity=26.9076305220884, Blast_Score=103, Evalue=7e-23,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_STRE4 (C0MAG2)

Other databases:

- EMBL:   FM204883
- RefSeq:   YP_002745458.1
- ProteinModelPortal:   C0MAG2
- EnsemblBacteria:   EBSTRT00000067987
- GeneID:   7697441
- GenomeReviews:   FM204883_GR
- KEGG:   seu:SEQ_0025
- GeneTree:   EBGT00050000027781
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26926; Mature: 26795

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQLIYSGKAKDIYETADDGIVLISYKDQVTMLNGAHKEMIEGKGSLNNQISALIFDRL
CCCCEEECCCCCHHHHCCCCCEEEEEECCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHH
NRVGVSTHFIKQLSETEQLNKRVAIIPLEVVLRNVAAGSFSKRFGVKEGQALDEPIIELY
HHCCHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHEE
YKNDALDDPFINDEHVSFLKLATDEQIAYIKQETHRINAYLKEWFASVGLTLVDFKLEFG
ECCCCCCCCCCCCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
FDKEGMLILADEFSPDNCRLWDNAGRHMDKDVFRRQLGSLTQAYETVLERLRALDQ
CCCCCEEEEEECCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNQLIYSGKAKDIYETADDGIVLISYKDQVTMLNGAHKEMIEGKGSLNNQISALIFDRL
CCCEEECCCCCHHHHCCCCCEEEEEECCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHH
NRVGVSTHFIKQLSETEQLNKRVAIIPLEVVLRNVAAGSFSKRFGVKEGQALDEPIIELY
HHCCHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHEE
YKNDALDDPFINDEHVSFLKLATDEQIAYIKQETHRINAYLKEWFASVGLTLVDFKLEFG
ECCCCCCCCCCCCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
FDKEGMLILADEFSPDNCRLWDNAGRHMDKDVFRRQLGSLTQAYETVLERLRALDQ
CCCCCEEEEEECCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA