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The map label for this gene is yfnA [H]

Identifier: 195977171

GI number: 195977171

Start: 16542

End: 18005

Strand: Direct

Name: yfnA [H]

Synonym: Sez_0015

Alternate gene names: 195977171

Gene position: 16542-18005 (Clockwise)

Preceding gene: 195977170

Following gene: 195977172

Centisome position: 0.82

GC content: 37.02

Gene sequence:

>1464_bases
GTGAAATTTACAATTGTCAGGAACTATGATAAACTAAGTAGAACCATTTTAAGACTAGAAAGTGACAAGATGACAATCTT
TCGGAAAAAAAGACAAGCTATTAATAAAACTGAGATGAATAGGCACTTAAAAATGCTGGATTTGATTTTTTTGGGCTTAG
GATCAATGGTAGGAACAGGTATTTTCACTATTACAGGCATAGGAACAGCTAACTATGCAGGGCCGGCATTGACCATTTCT
ATTATCCTTTCTGCTATTGCGATTAGTATTCTAGCCCTCTTTTATGCTGAATTTGCTTCACGAATTCCAGCAAATGGTGG
GGCTTATAGCTATGTTTATGCGACATTAGGTGAATTTCCAGCTTGGATTGTTGGCTGGTATATTATCATGGAATTTTTAA
CAGCAATTTCAAGTGTAGCTGTTGGCTGGGGAAGCTATTTAAAAGGCTTGCTGGCTAATTATGGCTTACAATTGCCCACT
GCTTTAAATGGTACCTTTGATCCTCAAAAAGGAACCTATATAGACTTACTTCCAGTATTGGTAATGCTCCTGGTTACCGC
AATTGTATTGATGAACTCAAAGGCAGCATTGCGATTCAATAGCTTTTTAGTTCTGTTAAAATTTTCAGCCCTAGCTTTAT
TTATCATTGTAGGCTTATTTTTTATTGATACAGCTAACTGGTCACCTTTTGCGCCTTATGGCTTTGGCCAAATTTATGGT
GGTAAGTCAGGTATTTTTGCTGGAGCCTCAGTCATGTTTTTTGCTTTCTTGGGCTTTGAGTCTATTTCCATGACAGTAGA
TGAGGTCAAAGAACCACAAAAAACAATTCCAAGAGGTATTGTATTATCCTTAACGATTGTAACGATCTTATATGTTATTG
TTACAATGGTTTTAACTGGGATTGTTCACTATACAAAATTAGATGTACCTGATGCAGTTGCCTTTGCTTTAAGAAGTATT
GGATTGCATTGGGCAGCAGATTATGTCTCAATTGTTGCCATTTTAACTCTAATTACAGTTTGTATTTCAATGACCTATGC
CTTAGCAAGAACGGTTTACAGTATCAGTAGAGATGGACTTTTACCAAGAGCCCTTTGTCAAATCACAGAAAAAACAAGAA
TTCCTAAAAATGCAACCCTAGTTGTTGGTGTATTATCTATGATTTGTGCAGGAATATTCCCCCTAGCCAGTCTTGCTGAG
TTTGTCAATATCTGTACTCTCGCTTATCTTGTCATCATGTCCTTTGCTATCATTAAGCTAAGAAAAAACGCTGGAGAGCC
TCAACGTGGGGAGTTTAAAACTCCTTTTGTGCCTCTCTTGCCAATTTTAGCTATTATCATCTGTGTAACCTTTATGAGTC
AGTACATGGTATTTACGTGGATTGCTTTTGGTATCAGCACTGTACTTGGCATTTTAGTCTATACATGCTATGGCTATACC
CATTCCCAAGAAAGAGGAAAATAA

Upstream 100 bases:

>100_bases
CTAACGAATAATGCTTAGTTGTTGTCATTACCTAAGATGAGTTAGGCTTCGTTCCTGGCTCATTTTTTAATAGGTTTTAA
GCTATATTGGGGTCGTTTTA

Downstream 100 bases:

>100_bases
AAGTCCAAAACTAGTTGACAAGTGTCGGTAAGATATCGTATACTAGTGAGGCTGTCGGCGAGCACTAGCTCAAGTTAATG
AAAAAAGGTAAAAAAAGTAG

Product: cationic amino acid transporter - APC superfamily

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKFTIVRNYDKLSRTILRLESDKMTIFRKKRQAINKTEMNRHLKMLDLIFLGLGSMVGTGIFTITGIGTANYAGPALTIS
IILSAIAISILALFYAEFASRIPANGGAYSYVYATLGEFPAWIVGWYIIMEFLTAISSVAVGWGSYLKGLLANYGLQLPT
ALNGTFDPQKGTYIDLLPVLVMLLVTAIVLMNSKAALRFNSFLVLLKFSALALFIIVGLFFIDTANWSPFAPYGFGQIYG
GKSGIFAGASVMFFAFLGFESISMTVDEVKEPQKTIPRGIVLSLTIVTILYVIVTMVLTGIVHYTKLDVPDAVAFALRSI
GLHWAADYVSIVAILTLITVCISMTYALARTVYSISRDGLLPRALCQITEKTRIPKNATLVVGVLSMICAGIFPLASLAE
FVNICTLAYLVIMSFAIIKLRKNAGEPQRGEFKTPFVPLLPILAIIICVTFMSQYMVFTWIAFGISTVLGILVYTCYGYT
HSQERGK

Sequences:

>Translated_487_residues
MKFTIVRNYDKLSRTILRLESDKMTIFRKKRQAINKTEMNRHLKMLDLIFLGLGSMVGTGIFTITGIGTANYAGPALTIS
IILSAIAISILALFYAEFASRIPANGGAYSYVYATLGEFPAWIVGWYIIMEFLTAISSVAVGWGSYLKGLLANYGLQLPT
ALNGTFDPQKGTYIDLLPVLVMLLVTAIVLMNSKAALRFNSFLVLLKFSALALFIIVGLFFIDTANWSPFAPYGFGQIYG
GKSGIFAGASVMFFAFLGFESISMTVDEVKEPQKTIPRGIVLSLTIVTILYVIVTMVLTGIVHYTKLDVPDAVAFALRSI
GLHWAADYVSIVAILTLITVCISMTYALARTVYSISRDGLLPRALCQITEKTRIPKNATLVVGVLSMICAGIFPLASLAE
FVNICTLAYLVIMSFAIIKLRKNAGEPQRGEFKTPFVPLLPILAIIICVTFMSQYMVFTWIAFGISTVLGILVYTCYGYT
HSQERGK
>Mature_487_residues
MKFTIVRNYDKLSRTILRLESDKMTIFRKKRQAINKTEMNRHLKMLDLIFLGLGSMVGTGIFTITGIGTANYAGPALTIS
IILSAIAISILALFYAEFASRIPANGGAYSYVYATLGEFPAWIVGWYIIMEFLTAISSVAVGWGSYLKGLLANYGLQLPT
ALNGTFDPQKGTYIDLLPVLVMLLVTAIVLMNSKAALRFNSFLVLLKFSALALFIIVGLFFIDTANWSPFAPYGFGQIYG
GKSGIFAGASVMFFAFLGFESISMTVDEVKEPQKTIPRGIVLSLTIVTILYVIVTMVLTGIVHYTKLDVPDAVAFALRSI
GLHWAADYVSIVAILTLITVCISMTYALARTVYSISRDGLLPRALCQITEKTRIPKNATLVVGVLSMICAGIFPLASLAE
FVNICTLAYLVIMSFAIIKLRKNAGEPQRGEFKTPFVPLLPILAIIICVTFMSQYMVFTWIAFGISTVLGILVYTCYGYT
HSQERGK

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=405, Percent_Identity=31.358024691358, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI181337167, Length=387, Percent_Identity=33.8501291989664, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI4507047, Length=433, Percent_Identity=28.8683602771363, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI258614003, Length=423, Percent_Identity=30.2600472813239, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI258614005, Length=423, Percent_Identity=30.0236406619385, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI114326544, Length=449, Percent_Identity=28.5077951002227, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI114326550, Length=449, Percent_Identity=28.5077951002227, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI258645169, Length=423, Percent_Identity=30.4964539007092, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI7657683, Length=378, Percent_Identity=26.7195767195767, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI186910308, Length=409, Percent_Identity=24.4498777506112, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI186910306, Length=409, Percent_Identity=24.4498777506112, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI186910304, Length=409, Percent_Identity=24.4498777506112, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI115648063, Length=431, Percent_Identity=22.969837587007, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI115648022, Length=431, Percent_Identity=22.969837587007, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI187423910, Length=438, Percent_Identity=20.7762557077626, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7657591, Length=438, Percent_Identity=20.7762557077626, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI33286428, Length=360, Percent_Identity=25.8333333333333, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI71979932, Length=400, Percent_Identity=25.75, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=22.9074889867841, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788480, Length=452, Percent_Identity=23.8938053097345, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081708, Length=444, Percent_Identity=23.8738738738739, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790653, Length=374, Percent_Identity=22.7272727272727, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082023, Length=447, Percent_Identity=23.2662192393736, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082250, Length=432, Percent_Identity=22.6851851851852, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786602, Length=421, Percent_Identity=22.5653206650831, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87081869, Length=428, Percent_Identity=21.0280373831776, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786789, Length=439, Percent_Identity=21.6400911161731, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786694, Length=395, Percent_Identity=24.5569620253165, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081915, Length=443, Percent_Identity=22.1218961625282, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI48994972, Length=351, Percent_Identity=21.0826210826211, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=460, Percent_Identity=33.9130434782609, Blast_Score=235, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17533459, Length=414, Percent_Identity=34.2995169082126, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17531343, Length=415, Percent_Identity=32.7710843373494, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17540018, Length=442, Percent_Identity=26.0180995475113, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71982612, Length=452, Percent_Identity=23.4513274336283, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71982608, Length=451, Percent_Identity=23.5033259423503, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32566699, Length=315, Percent_Identity=24.4444444444444, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17568033, Length=447, Percent_Identity=25.2796420581655, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193208714, Length=432, Percent_Identity=22.4537037037037, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32566695, Length=432, Percent_Identity=22.4537037037037, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537453, Length=375, Percent_Identity=21.3333333333333, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24667468, Length=436, Percent_Identity=34.8623853211009, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI221512776, Length=413, Percent_Identity=32.6876513317191, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24666159, Length=415, Percent_Identity=32.5301204819277, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24668806, Length=410, Percent_Identity=32.9268292682927, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21356285, Length=410, Percent_Identity=32.9268292682927, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24668802, Length=410, Percent_Identity=32.9268292682927, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI161077963, Length=415, Percent_Identity=33.0120481927711, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI281366235, Length=413, Percent_Identity=30.7506053268765, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI116007820, Length=413, Percent_Identity=30.7506053268765, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI116007818, Length=413, Percent_Identity=30.7506053268765, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI85725152, Length=413, Percent_Identity=30.7506053268765, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21357367, Length=365, Percent_Identity=21.9178082191781, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221331183, Length=352, Percent_Identity=23.5795454545455, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17647653, Length=352, Percent_Identity=23.5795454545455, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664379, Length=352, Percent_Identity=23.5795454545455, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45550968, Length=352, Percent_Identity=25, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19921172, Length=352, Percent_Identity=25, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24651635, Length=425, Percent_Identity=24.7058823529412, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651633, Length=425, Percent_Identity=24.7058823529412, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53436; Mature: 53436

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTIVRNYDKLSRTILRLESDKMTIFRKKRQAINKTEMNRHLKMLDLIFLGLGSMVGTG
CEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IFTITGIGTANYAGPALTISIILSAIAISILALFYAEFASRIPANGGAYSYVYATLGEFP
HHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AWIVGWYIIMEFLTAISSVAVGWGSYLKGLLANYGLQLPTALNGTFDPQKGTYIDLLPVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
VMLLVTAIVLMNSKAALRFNSFLVLLKFSALALFIIVGLFFIDTANWSPFAPYGFGQIYG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCC
GKSGIFAGASVMFFAFLGFESISMTVDEVKEPQKTIPRGIVLSLTIVTILYVIVTMVLTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IVHYTKLDVPDAVAFALRSIGLHWAADYVSIVAILTLITVCISMTYALARTVYSISRDGL
HHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LPRALCQITEKTRIPKNATLVVGVLSMICAGIFPLASLAEFVNICTLAYLVIMSFAIIKL
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKNAGEPQRGEFKTPFVPLLPILAIIICVTFMSQYMVFTWIAFGISTVLGILVYTCYGYT
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HSQERGK
CCCCCCC
>Mature Secondary Structure
MKFTIVRNYDKLSRTILRLESDKMTIFRKKRQAINKTEMNRHLKMLDLIFLGLGSMVGTG
CEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IFTITGIGTANYAGPALTISIILSAIAISILALFYAEFASRIPANGGAYSYVYATLGEFP
HHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AWIVGWYIIMEFLTAISSVAVGWGSYLKGLLANYGLQLPTALNGTFDPQKGTYIDLLPVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
VMLLVTAIVLMNSKAALRFNSFLVLLKFSALALFIIVGLFFIDTANWSPFAPYGFGQIYG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCC
GKSGIFAGASVMFFAFLGFESISMTVDEVKEPQKTIPRGIVLSLTIVTILYVIVTMVLTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IVHYTKLDVPDAVAFALRSIGLHWAADYVSIVAILTLITVCISMTYALARTVYSISRDGL
HHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LPRALCQITEKTRIPKNATLVVGVLSMICAGIFPLASLAEFVNICTLAYLVIMSFAIIKL
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKNAGEPQRGEFKTPFVPLLPILAIIICVTFMSQYMVFTWIAFGISTVLGILVYTCYGYT
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HSQERGK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]