Click here to switch to the map view.

The map label for this gene is dnaA [H]

Identifier: 195977157

GI number: 195977157

Start: 233

End: 1585

Strand: Direct

Name: dnaA [H]

Synonym: Sez_0001

Alternate gene names: 195977157

Gene position: 233-1585 (Clockwise)

Preceding gene: NA

Following gene: 195977158

Centisome position: 0.01

GC content: 38.43

Gene sequence:

>1353_bases
ATGACTGAAAATGAACAAATTTTTTGGAATAGGGTCTTAGAGCTAGCTCAAAGCCAGTTAAAGCAGGCAACTTATGAATT
TTTTGTTCATGATGCTCGTTTGATCAAGGTAGACAATCATGTCGCAACAATTTTTTTAGATCAGATGAAGGAATTGTTTT
GGGAAAAAAATCTCAAAGACGTTATCTTAACAGCAGGATTTGAAGTTTACAATGCTCAAATTGCTGTAGACTACGTCTAT
GAGGAGGACTTGATTATTGAGCAACAGCATCAGGGACAGCAAGGATATACTGAACAAGCCTTTCAGCAATTACCAGCAGT
ACAGTCCGATCTAAACCCTAAATACAGCTTTGATAACTTTATCCAAGGTGATGAAAATAGGTGGGCTGTTGCTGCTTCAA
TAGCAGTAGCTAATACCCCAGGCACAACCTACAATCCTTTATTCATCTGGGGAGGACCAGGTCTTGGTAAGACTCATCTT
TTAAATGCTATTGGAAATTCAGTTTTACTGGAAAATCCAAATGCCAGGATCAAATACATTACGGCTGAAAATTTTATTAA
TGAATTTGTTGTCCATATTCGTCTAGATACTATGGACGAGCTAAAGGAGAAGTTTCGCAATCTTGATCTCCTCCTAATTG
ATGACATTCAATCTCTAGCTAAAAAAACCTTGTCTGGTACGCAAGAGGAGTTCTTTAACACCTTCAATGCTCTACATAAC
AACAACAAGCAAATTGTTTTAACGAGTGACCGAACTCCTGATCATCTCAATGACCTAGAGGATCGCCTAGTGACTCGATT
TAAGTGGGGACTAACGGTTAATATTACACCGCCTGATTTTGAAACACGCGTTGCTATTTTGACCAATAAAATTCAAGAAT
ATAATTTCATCTTTCCTCAGGACACCATCGAATATTTGGCCGGTCAATTTGACTCTAATGTCAGAGACCTGGAGGGGGCT
TTGAAGGATATTAGTCTTGTGGCTAATTTTAAACAAATTGATACAATTACAGTAGACATAGCAGCAGAAGCTATTCGAGC
TAGAAAGCAAGACGGTCCTAAGATGACTGTCATTCCAATTGAAGAAATCCAAGCTCAGGTTGGAAAATTTTATGGGGTTA
CGGTTAAGGAAATCAAGGCGACCAAACGCACACAGGATATCGTGCTTGCTAGACAGGTTGCTATGTTTTTAGCTCGTGAG
ATGACCGATAACAGTCTGCCAAAGATCGGTAAAGAATTTGGAGGACGTGATCATTCAACTGTGCTTCATGCTTATAACAA
AATTAAAAACATGATTGGACAAGACGAGAGCCTCAGAATTGAAATTGAAACCATCAAGAACAAAATCAAATAA

Upstream 100 bases:

>100_bases
AGCTTGTGGGTAAGTCAAAAATAATCCCTGATCCTTTGTGGAAAACTATCTTTATTTATGATAGAATGGTTCTAGAATTA
TCCACAAGAAGGAATCTCGT

Downstream 100 bases:

>100_bases
GCAATGTGGATAACCTTTAGCAAAAAGGAAAATTTATCCACAGCTTGTGCACAAGCGTTTTAACTAGTAACGACTAGTAC
AAGGAGACTTATCCACTATT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLIKVDNHVATIFLDQMKELFWEKNLKDVILTAGFEVYNAQIAVDYVY
EEDLIIEQQHQGQQGYTEQAFQQLPAVQSDLNPKYSFDNFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHL
LNAIGNSVLLENPNARIKYITAENFINEFVVHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHN
NNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEGA
LKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQAQVGKFYGVTVKEIKATKRTQDIVLARQVAMFLARE
MTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMIGQDESLRIEIETIKNKIK

Sequences:

>Translated_450_residues
MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLIKVDNHVATIFLDQMKELFWEKNLKDVILTAGFEVYNAQIAVDYVY
EEDLIIEQQHQGQQGYTEQAFQQLPAVQSDLNPKYSFDNFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHL
LNAIGNSVLLENPNARIKYITAENFINEFVVHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHN
NNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEGA
LKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQAQVGKFYGVTVKEIKATKRTQDIVLARQVAMFLARE
MTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMIGQDESLRIEIETIKNKIK
>Mature_449_residues
TENEQIFWNRVLELAQSQLKQATYEFFVHDARLIKVDNHVATIFLDQMKELFWEKNLKDVILTAGFEVYNAQIAVDYVYE
EDLIIEQQHQGQQGYTEQAFQQLPAVQSDLNPKYSFDNFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHLL
NAIGNSVLLENPNARIKYITAENFINEFVVHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHNN
NKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEGAL
KDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQAQVGKFYGVTVKEIKATKRTQDIVLARQVAMFLAREM
TDNSLPKIGKEFGGRDHSTVLHAYNKIKNMIGQDESLRIEIETIKNKIK

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=342, Percent_Identity=46.4912280701754, Blast_Score=305, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 51491; Mature: 51360

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLIKVDNHVATIFLDQMKELFWEKNLKD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHH
VILTAGFEVYNAQIAVDYVYEEDLIIEQQHQGQQGYTEQAFQQLPAVQSDLNPKYSFDNF
HHHCCCCEEEEEEEEEEEEECCCEEEEHHHCCCCCHHHHHHHHCCCHHHCCCCCCCCCCC
IQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHLLNAIGNSVLLENPNARIKYI
CCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEECCCCCEEEE
TAENFINEFVVHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHN
EHHHHHHHEEEEEEECCHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHC
NNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQ
CCCEEEEECCCCCHHHHHHHHHHHHHEECCEEEEECCCCCHHHHHHHHHHHHHCCEECCH
DTIEYLAGQFDSNVRDLEGALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHCEEEEHHHHHHHHHHHCCCCEEEEEEH
EEIQAQVGKFYGVTVKEIKATKRTQDIVLARQVAMFLAREMTDNSLPKIGKEFGGRDHST
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHH
VLHAYNKIKNMIGQDESLRIEIETIKNKIK
HHHHHHHHHHHHCCCCCEEEEEEHHHCCCC
>Mature Secondary Structure 
TENEQIFWNRVLELAQSQLKQATYEFFVHDARLIKVDNHVATIFLDQMKELFWEKNLKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHH
VILTAGFEVYNAQIAVDYVYEEDLIIEQQHQGQQGYTEQAFQQLPAVQSDLNPKYSFDNF
HHHCCCCEEEEEEEEEEEEECCCEEEEHHHCCCCCHHHHHHHHCCCHHHCCCCCCCCCCC
IQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHLLNAIGNSVLLENPNARIKYI
CCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEECCCCCEEEE
TAENFINEFVVHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHN
EHHHHHHHEEEEEEECCHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHC
NNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQ
CCCEEEEECCCCCHHHHHHHHHHHHHEECCEEEEECCCCCHHHHHHHHHHHHHCCEECCH
DTIEYLAGQFDSNVRDLEGALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHCEEEEHHHHHHHHHHHCCCCEEEEEEH
EEIQAQVGKFYGVTVKEIKATKRTQDIVLARQVAMFLAREMTDNSLPKIGKEFGGRDHST
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHH
VLHAYNKIKNMIGQDESLRIEIETIKNKIK
HHHHHHHHHHHHCCCCCEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10930754; 11296296 [H]