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The map label for this gene is lpxC [H]

Identifier: 195953016

GI number: 195953016

Start: 575323

End: 576198

Strand: Direct

Name: lpxC [H]

Synonym: HY04AAS1_0641

Alternate gene names: 195953016

Gene position: 575323-576198 (Clockwise)

Preceding gene: 195953015

Following gene: 195953017

Centisome position: 36.89

GC content: 32.42

Gene sequence:

>876_bases
ATGAGAAACGAATGCTTTTTGCAAAATACCATATCTGATTCTTTTACAATAGAGGGCATAGGCATACACTCAGGTGCAAT
ATCGAAGGTAAAGTTCCACCCAGCAGAAGAAAATACAGGCATAATCTTTATGAGGAATGCTTATAAAGTAAAAGCTCATG
TAGAAAATGTAGTAGATACTTCAAATTCAACATCTATAGGAAACGGCATAGCAACTTTTAGAACCATAGAACATATAATG
GCAGCCTTATATTTAGCAGATATAGACAATATAATAGTGGAGTTTGTAAATTCTGAAGAATCCCCTATTATGGATGGTAG
CGCTTGTGAATTTTTTAAGCTTTTAGAAAAATACAAAGTGGCTCAAGATACTCCTAAATATTTTGGCCATCTTTCAAATA
TTGTAAGAGTTTCAGATGGCGACAAATATATAATGGCAAAACCACAAAAAAGTTTATCTATTATATTTGAAGGATTTTTT
GGAAATTTTCTGAAGCATCAAATTTATAATTACAACTCCGAATTGGAAAAACCACACATAGATAGAAAGCTCATAAGCGC
TAGAACGTTTTGTCATATAGAAGACATAGAAAAACTTAGAAAGTTAGGCCTTGGGAAAGGTGGCTCTTTAGAAAATAACA
TAGTCCTTACAGATACAGGTGTGTTAAATAAAGAGGGGCTAAGGCACTCTCATGAGCCTGTAAGCCATAAAGTCCTAGAC
TTAATAGGAGATTTATATTTAACTGGTGTAAGATTTTCAGCAAACATATATTCTTACATGGGTGGACATAGATTAAACAT
TGAATTTGTAAAAGAAGCCATAAAACATATAAAAGTATCTGAACATCTATTAGAAACAACAAAAACAGCTTCATAA

Upstream 100 bases:

>100_bases
GAAGGATTTCAAGTGACTTACGTCCCCCAGAAACCAAGCGTAGAATCTATAGCAAAATATATATCATCTATTGGCACATA
ATTTGCTCATATAATTTTAT

Downstream 100 bases:

>100_bases
AACACTTTTAGATAATCACATAAATTTCATGATATACTAATATAATATTGCGTGGAGGTAATTATGAATATTGAATTTAA
AAAAGCTAAACTTTTTAAGC

Product: UDP-3-0-acyl N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MRNECFLQNTISDSFTIEGIGIHSGAISKVKFHPAEENTGIIFMRNAYKVKAHVENVVDTSNSTSIGNGIATFRTIEHIM
AALYLADIDNIIVEFVNSEESPIMDGSACEFFKLLEKYKVAQDTPKYFGHLSNIVRVSDGDKYIMAKPQKSLSIIFEGFF
GNFLKHQIYNYNSELEKPHIDRKLISARTFCHIEDIEKLRKLGLGKGGSLENNIVLTDTGVLNKEGLRHSHEPVSHKVLD
LIGDLYLTGVRFSANIYSYMGGHRLNIEFVKEAIKHIKVSEHLLETTKTAS

Sequences:

>Translated_291_residues
MRNECFLQNTISDSFTIEGIGIHSGAISKVKFHPAEENTGIIFMRNAYKVKAHVENVVDTSNSTSIGNGIATFRTIEHIM
AALYLADIDNIIVEFVNSEESPIMDGSACEFFKLLEKYKVAQDTPKYFGHLSNIVRVSDGDKYIMAKPQKSLSIIFEGFF
GNFLKHQIYNYNSELEKPHIDRKLISARTFCHIEDIEKLRKLGLGKGGSLENNIVLTDTGVLNKEGLRHSHEPVSHKVLD
LIGDLYLTGVRFSANIYSYMGGHRLNIEFVKEAIKHIKVSEHLLETTKTAS
>Mature_291_residues
MRNECFLQNTISDSFTIEGIGIHSGAISKVKFHPAEENTGIIFMRNAYKVKAHVENVVDTSNSTSIGNGIATFRTIEHIM
AALYLADIDNIIVEFVNSEESPIMDGSACEFFKLLEKYKVAQDTPKYFGHLSNIVRVSDGDKYIMAKPQKSLSIIFEGFF
GNFLKHQIYNYNSELEKPHIDRKLISARTFCHIEDIEKLRKLGLGKGGSLENNIVLTDTGVLNKEGLRHSHEPVSHKVLD
LIGDLYLTGVRFSANIYSYMGGHRLNIEFVKEAIKHIKVSEHLLETTKTAS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=283, Percent_Identity=34.6289752650177, Blast_Score=144, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32726; Mature: 32726

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNECFLQNTISDSFTIEGIGIHSGAISKVKFHPAEENTGIIFMRNAYKVKAHVENVVDT
CCCCEEEHHCCCCCEEEEEEEECCCCCCEEEEECCCCCCCEEEEECCEEEHHHHHHHHCC
SNSTSIGNGIATFRTIEHIMAALYLADIDNIIVEFVNSEESPIMDGSACEFFKLLEKYKV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
AQDTPKYFGHLSNIVRVSDGDKYIMAKPQKSLSIIFEGFFGNFLKHQIYNYNSELEKPHI
HCCCHHHHHHHHHEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DRKLISARTFCHIEDIEKLRKLGLGKGGSLENNIVLTDTGVLNKEGLRHSHEPVSHKVLD
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
LIGDLYLTGVRFSANIYSYMGGHRLNIEFVKEAIKHIKVSEHLLETTKTAS
HHHHHHHHCEEEECHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRNECFLQNTISDSFTIEGIGIHSGAISKVKFHPAEENTGIIFMRNAYKVKAHVENVVDT
CCCCEEEHHCCCCCEEEEEEEECCCCCCEEEEECCCCCCCEEEEECCEEEHHHHHHHHCC
SNSTSIGNGIATFRTIEHIMAALYLADIDNIIVEFVNSEESPIMDGSACEFFKLLEKYKV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
AQDTPKYFGHLSNIVRVSDGDKYIMAKPQKSLSIIFEGFFGNFLKHQIYNYNSELEKPHI
HCCCHHHHHHHHHEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DRKLISARTFCHIEDIEKLRKLGLGKGGSLENNIVLTDTGVLNKEGLRHSHEPVSHKVLD
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
LIGDLYLTGVRFSANIYSYMGGHRLNIEFVKEAIKHIKVSEHLLETTKTAS
HHHHHHHHCEEEECHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]