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The map label for this gene is sul [H]

Identifier: 195952385

GI number: 195952385

Start: 4258

End: 5445

Strand: Direct

Name: sul [H]

Synonym: HY04AAS1_0005

Alternate gene names: 195952385

Gene position: 4258-5445 (Clockwise)

Preceding gene: 195952384

Following gene: 195952386

Centisome position: 0.27

GC content: 33.5

Gene sequence:

>1188_bases
ATGAAAATAACATTTTTAAATACGTCAAAAGACGTCCATGTATATATAAAAAGAAATATCCATTACAGTATTAAAACCGA
AGACGTATCTAAAATAGTGCCCTCTTTTGCTATAAAGTTTGAGGGCTTTTTAGAGAAAAACGTGCTAGAAAATGCTGCTC
GTTTTGGTGTATTTTGCCACAATCAGGGGAAATATGCATTTGTTATAGGAAATAAGTTTGGTATTTTTGAGCTTTTAAAA
GCCACAAAACCAAAAATAGCTAAAGAACTTATAAAGCATATTATTAATTTTGGCAAAGAGCACCGTTACAACATATCTTA
CAACACAAAAGTTTTGCACCTTTCAGACATGAAACCACTTGTAATGGGAGTTATAAATATAACCAAAGATTCCTTTTACG
CACCTTCAAGGGTGGATGAGAAAGATATACTTTTTAGAGTAGAAGAGTTTATAAAAGAGGGTGCAGATATAATAGATATA
GGAGCTCAATCTACTAGACCTGGAGCAGAGGAAATATCTTCTGAGGAAGAGGTTCGTAAGCTTTTAGAACCCTTAAGAAA
GATAAGAAAAGAGTTTAAGAATGTGTGGATATCCATAGATACATATTTTTCCAATACTGCTAGGGTATGTCTTGAAGAAG
GGGCAGATATTATAAACGATATAAGTGGTGGAGTTTTTGACGATGATATACTAAAAACTATAGCTGTTTATAACTGCCCT
TACATCATAGGACATTCCTCTTCGTACAAACCAAATCAGTGGCCCCATACAGATTTTGAGTATGAGGATATAACCCTTGA
AATTATAAATCATTTTAAAAGCCAAGAGACAAAGCTTTTAGAACTTGGGTATAATCTCTTTAACGGCATAATCATAGACC
CATGTATAGGCTTTGCCAAAAAACCTATGCACAACTTAGAAATTTTAAATCAGATAGAAGCTCTTAGAAGTCTTGATAGG
CCAATTCTTATAGGTACTTCAAGAAAATCTTTTATAGGTATAGTGATAAAAGAGTTTTTACAAAAAGAATCTATACCAGC
CCCAGAGCAAAGGCTTGTAGGAAGTCTTGGGTCTATAGCCCAAAGTATTACAAAAAACGCTTGCCATATTGTAAGAACCC
ATGATGTAGCTACTACTAAAGAGTTTATAGCGCTTTTAGATGCAATAAGGAATTATCATTATGCTTGA

Upstream 100 bases:

>100_bases
ACATTGTTTCAAACGCCATGGCTCAGGATTTTTCTTGGAGAAGAAGTGTCCAAGAGTATATAAAAATTTATAAAACTGCA
AAGCTTATAAAAATGCACTG

Downstream 100 bases:

>100_bases
GATACTGCATTTTATCACCCTTAAAGATATTATAGATATAGCTTTGGTCTATTTTCTCGTATACGAAGTCATATATTACA
TGGCAAAATCAAGGGGAGGT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKITFLNTSKDVHVYIKRNIHYSIKTEDVSKIVPSFAIKFEGFLEKNVLENAARFGVFCHNQGKYAFVIGNKFGIFELLK
ATKPKIAKELIKHIINFGKEHRYNISYNTKVLHLSDMKPLVMGVINITKDSFYAPSRVDEKDILFRVEEFIKEGADIIDI
GAQSTRPGAEEISSEEEVRKLLEPLRKIRKEFKNVWISIDTYFSNTARVCLEEGADIINDISGGVFDDDILKTIAVYNCP
YIIGHSSSYKPNQWPHTDFEYEDITLEIINHFKSQETKLLELGYNLFNGIIIDPCIGFAKKPMHNLEILNQIEALRSLDR
PILIGTSRKSFIGIVIKEFLQKESIPAPEQRLVGSLGSIAQSITKNACHIVRTHDVATTKEFIALLDAIRNYHYA

Sequences:

>Translated_395_residues
MKITFLNTSKDVHVYIKRNIHYSIKTEDVSKIVPSFAIKFEGFLEKNVLENAARFGVFCHNQGKYAFVIGNKFGIFELLK
ATKPKIAKELIKHIINFGKEHRYNISYNTKVLHLSDMKPLVMGVINITKDSFYAPSRVDEKDILFRVEEFIKEGADIIDI
GAQSTRPGAEEISSEEEVRKLLEPLRKIRKEFKNVWISIDTYFSNTARVCLEEGADIINDISGGVFDDDILKTIAVYNCP
YIIGHSSSYKPNQWPHTDFEYEDITLEIINHFKSQETKLLELGYNLFNGIIIDPCIGFAKKPMHNLEILNQIEALRSLDR
PILIGTSRKSFIGIVIKEFLQKESIPAPEQRLVGSLGSIAQSITKNACHIVRTHDVATTKEFIALLDAIRNYHYA
>Mature_395_residues
MKITFLNTSKDVHVYIKRNIHYSIKTEDVSKIVPSFAIKFEGFLEKNVLENAARFGVFCHNQGKYAFVIGNKFGIFELLK
ATKPKIAKELIKHIINFGKEHRYNISYNTKVLHLSDMKPLVMGVINITKDSFYAPSRVDEKDILFRVEEFIKEGADIIDI
GAQSTRPGAEEISSEEEVRKLLEPLRKIRKEFKNVWISIDTYFSNTARVCLEEGADIINDISGGVFDDDILKTIAVYNCP
YIIGHSSSYKPNQWPHTDFEYEDITLEIINHFKSQETKLLELGYNLFNGIIIDPCIGFAKKPMHNLEILNQIEALRSLDR
PILIGTSRKSFIGIVIKEFLQKESIPAPEQRLVGSLGSIAQSITKNACHIVRTHDVATTKEFIALLDAIRNYHYA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=271, Percent_Identity=32.4723247232472, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=31.7901234567901, Blast_Score=107, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 45075; Mature: 45075

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITFLNTSKDVHVYIKRNIHYSIKTEDVSKIVPSFAIKFEGFLEKNVLENAARFGVFCH
CEEEEEECCCCEEEEEEECEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
NQGKYAFVIGNKFGIFELLKATKPKIAKELIKHIINFGKEHRYNISYNTKVLHLSDMKPL
CCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCHH
VMGVINITKDSFYAPSRVDEKDILFRVEEFIKEGADIIDIGAQSTRPGAEEISSEEEVRK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCHHHHHH
LLEPLRKIRKEFKNVWISIDTYFSNTARVCLEEGADIINDISGGVFDDDILKTIAVYNCP
HHHHHHHHHHHHHHEEEEEEHHHCCHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHCCC
YIIGHSSSYKPNQWPHTDFEYEDITLEIINHFKSQETKLLELGYNLFNGIIIDPCIGFAK
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHH
KPMHNLEILNQIEALRSLDRPILIGTSRKSFIGIVIKEFLQKESIPAPEQRLVGSLGSIA
CCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QSITKNACHIVRTHDVATTKEFIALLDAIRNYHYA
HHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKITFLNTSKDVHVYIKRNIHYSIKTEDVSKIVPSFAIKFEGFLEKNVLENAARFGVFCH
CEEEEEECCCCEEEEEEECEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
NQGKYAFVIGNKFGIFELLKATKPKIAKELIKHIINFGKEHRYNISYNTKVLHLSDMKPL
CCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCHH
VMGVINITKDSFYAPSRVDEKDILFRVEEFIKEGADIIDIGAQSTRPGAEEISSEEEVRK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCHHHHHH
LLEPLRKIRKEFKNVWISIDTYFSNTARVCLEEGADIINDISGGVFDDDILKTIAVYNCP
HHHHHHHHHHHHHHEEEEEEHHHCCHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHCCC
YIIGHSSSYKPNQWPHTDFEYEDITLEIINHFKSQETKLLELGYNLFNGIIIDPCIGFAK
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHH
KPMHNLEILNQIEALRSLDRPILIGTSRKSFIGIVIKEFLQKESIPAPEQRLVGSLGSIA
CCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QSITKNACHIVRTHDVATTKEFIALLDAIRNYHYA
HHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]