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The map label for this gene is menA [H]

Identifier: 194738345

GI number: 194738345

Start: 4175205

End: 4176146

Strand: Reverse

Name: menA [H]

Synonym: SeSA_A4306

Alternate gene names: 194738345

Gene position: 4176146-4175205 (Counterclockwise)

Preceding gene: 194733928

Following gene: 194735603

Centisome position: 88.68

GC content: 54.99

Gene sequence:

>942_bases
TTGGCGCTAAATATGACTGAACAACAACAAATTAGCCGCACCCAGGCCTGGCTGGAAAGCTTACGACCCAAAACCTTACC
CCTCGCCTTTGCGGCGATTATCGTCGGTACGGCCCTGGCATGGTGGCAAGGCTATTTCGATCCTCTGGTCGCACTGCTGG
CCCTTATCACCGCCGGGCTGCTGCAAATTTTATCCAACCTCGCCAACGATTACGGCGACGCTGTCAAAGGCAGTGATAAA
CCGGATCGCATCGGGCCGCTGCGGGGGATGCAAAAAGGCGTCATCACCCGGCAGGAGATGAAGCGGGCGTTAATCATTAC
CGTCGTGCTGATCTGTATCTCCGGACTGGCGCTGGTGGCGGTCGCGTGCCATACGTTAACCGATTTTGTCGGCTTCCTGA
TTTTGGGCGGGCTGTCGATTATCGCCGCCATCACCTACACCGTGGGTAATCGGCCCTACGGTTATATCGGGCTGGGTGAT
ATCTCTGTCCTGGTATTCTTTGGCTGGCTAAGTGTCATGGGGAGCTGGTATCTCCAGGCGCATACGTTGATTCCGGCGCT
AATTCTCCCGGCCACCGCCTGCGGTTTACTGGCGACGGCGGTGCTGAATATTAATAATCTGCGCGATATTAATAGCGACA
GAGAGAACGGCAAAAACACCCTTGTGGTACGACTCGGCGATGTCAACGCGCGTCGTTATCACGCCTGCCTGTTGCTAGGC
GCGCTGCTCTGTCTGGCGCTGTTTAATCTGCTCTCGCTACACAGTCCGTGGGGATGGTTGTTTATTCTGGCCGCGCCATT
GCTCATTAAACAAGCGCGCTACGTAATGCGCGAAAGGGAGCCTGCGGCAATGCGCCCGATGCTTGAACGTACCGTTAAAG
GCGCGTTGTTAACCAACCTGTTATTTGTGATTGGGATACTCTTAAGTCAGTGGGCCGTTTAA

Upstream 100 bases:

>100_bases
GGATGCGCTGGTCGCAGATGAAGATCTAAGTCGTTTTATCTTATAATCGCGTCCAATGCATTTTCATCACTGTTGATGGG
GCTGAAAAGCCCCATTTTTA

Downstream 100 bases:

>100_bases
CTGACAAATATCAATTAACAATTGATGATTTTGCCAACAGTATACTTAGCGCGATATACTAAAAATTCTCGCAGCAACTG
AACGTTAAGCCTATGAAATA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MALNMTEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGLLQILSNLANDYGDAVKGSDK
PDRIGPLRGMQKGVITRQEMKRALIITVVLICISGLALVAVACHTLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGD
ISVLVFFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLG
ALLCLALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNLLFVIGILLSQWAV

Sequences:

>Translated_313_residues
MALNMTEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGLLQILSNLANDYGDAVKGSDK
PDRIGPLRGMQKGVITRQEMKRALIITVVLICISGLALVAVACHTLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGD
ISVLVFFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLG
ALLCLALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNLLFVIGILLSQWAV
>Mature_312_residues
ALNMTEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKP
DRIGPLRGMQKGVITRQEMKRALIITVVLICISGLALVAVACHTLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDI
SVLVFFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLGA
LLCLALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNLLFVIGILLSQWAV

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=305, Percent_Identity=29.8360655737705, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1790365, Length=308, Percent_Identity=94.1558441558442, Blast_Score=584, Evalue=1e-168,
Organism=Drosophila melanogaster, GI17737429, Length=295, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34171; Mature: 34040

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNMTEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGL
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQILSNLANDYGDAVKGSDKPDRIGPLRGMQKGVITRQEMKRALIITVVLICISGLALVA
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VACHTLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLVFFGWLSVMGSWYLQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
HTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
ALLCLALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LFVIGILLSQWAV
HHHHHHHHHHCCC
>Mature Secondary Structure 
ALNMTEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGL
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQILSNLANDYGDAVKGSDKPDRIGPLRGMQKGVITRQEMKRALIITVVLICISGLALVA
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VACHTLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLVFFGWLSVMGSWYLQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
HTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
ALLCLALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LFVIGILLSQWAV
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]