| Definition | Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633 chromosome, complete genome. |
|---|---|
| Accession | NC_011094 |
| Length | 4,709,075 |
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The map label for this gene is metE [H]
Identifier: 194738289
GI number: 194738289
Start: 4048152
End: 4050416
Strand: Direct
Name: metE [H]
Synonym: SeSA_A4172
Alternate gene names: 194738289
Gene position: 4048152-4050416 (Clockwise)
Preceding gene: 194736470
Following gene: 194737906
Centisome position: 85.96
GC content: 57.75
Gene sequence:
>2265_bases ATGACAATATTGACTCACACCCTCGGTTTTCCTCGCGTTGGCCTGCGTCGCGAGTTGAAAAAAGCGCAAGAGAGCTACTG GGCGGGGAACTCAACGCGTGAAGCGTTACTGGCGGTGGGGCGCGAACTGCGCGCGCGTCACTGGGAGCAGCAGAAACAAG CGGGTATTGACCTGTTACCGGTAGGCGACTTTGCCTGGTACGACCATGTTCTGACCACCAGCCTGCTGTTAGGCAATGTG CCGGCTCGTCATCAGAACAACGACGGTTCCGTGGACATCGACACTCTGTTCCGCATTGGCCGCGGTCGCGCGCCAACCGG CGAACCGGCGGCGGCAGCGGAAATGACCAAATGGTTTAATACTAACTATCACTACATAGTACCGGAGTTCAGCAAAGGCC AGCAGTTCAGACTCACCTGGACACAGTTGCTGGAGGAAGTGGACGAAGCGCTGGCGCTGGGGCATAAGATCAAACCCGTA CTGCTGGGGCCTGTCACGTATCTGTGGCTGGGTAAAGTGAAAGGCGAGCCGTTTGACCGCCTGACGTTGCTGAAAGACAT TTTGCCAGTGTATCAGCACGTGCTGGCTGAACTGGCGAAGCGTGGTATTGAGTGGGTCCAAATTGATGAGCCAGCGCTGG TGCTGGAACTGCCGCAGGCGTGGCTGGATGCCTTCAAACCGGCTTACGACGCGCTCGCCGGCCAGGTGAAGCTGTTGCTG ACGACCTATTTTGAAGGCGTGACGCCAAACCTGGACACTATTATCGCGCTACCGGTACAGGGGCTACATGTTGACCTCAT TCATGGTAAAGATGATGTAGCGGAACTGCATCAACGTCTGCCGGTCGACTGGCTGCTTTCTGCAGGCTTGATTAACGGGC GTAATGTCTGGCGCGCCGATTTGACCGAAAAATACGCGCAGATTAACGCCATTGTGGGCAAACGCGCGCTGTGGGTAGCA TCCTCCTGCTCTTTGCTGCACAGCCCGATCGATCTCAGCGTCGAAACGCGTCTGGATACGGAAGTTAAAAGCTGGTTTGC CTTTGCGCTGCAAAAATGCGGTGAACTGGCGTTGCTGCGCGATGCGCTGAACAGCGGCGAAACGGCGGCGCTTGAGGAAT GGAGCGCACCGATTCAGGCTCGTCGTCACTCCCGCCGCGTACATAATGCCGCGGTAGAAAAACGCCTGGCGGCGATCACC GCGCAGGACAGCCAGCGTGAGAATCCGTATGAGGTGCGCGCTGAAGCGCAACGCGCCCGCTTTAAACTTCCCGCCTGGCC GACGACGACTATCGGTTCGTTTCCGCAAACCACGGAAATTCGCGGCCTGCGTCTGGACTTCAAAAAGGGCAACCTCGACG CGAATAACTACCGCACCGGCATCGCCGAACATATCAAACAGGCTATCATCGAGCAGGAGCGTTTAGGGCTGGATGTGCTG GTACACGGCGAAGCCGAGCGAAACGACATGGTGGAATACTTCGGCGAGCATCTGGACGGCTTCGTCTTTACCCAGAATGG TTGGGTGCAAAGCTATGGCTCCCGCTGTGTGAAACCGCCGGTAGTGATTGGCGATATCAGCCGTCCGGCACCGATTACCG TGGAGTGGGCGAAATATGCCCAGTCGCTGACCGACAAGCCGGTAAAAGGGATGTTGACCGGCCCGGTGACTATTCTTTGC TGGTCATTCCCCCGCGAAGACGTGACCCGCGAAACGATTGCGAAACAGATTGCGCTGGCGCTGCGTGATGAAGTCGCGGA TCTGGAGGCGGCGGGGATTGGGATTATTCAGATCGACGAACCGGCGCTGCGCGAAGGTCTACCGCTGCGTCGCAGCGACT GGGACGCCTATCTGGAATGGGGTGTGGAAGCCTTCCGCATCAACGCGGCGGTGGCGAAGGATGAAACCCAGATCCACACC CACATGTGTTACTGCGAGTTCAACGACATTATGGATTCGATCGCCGCGCTGGATGCGGATGTGATCACCATTGAGACCTC CCGCTCGGATATGGAGTTGCTGGAGTCGTTCGAAGCGTTCGATTACCCGAACGAAATCGGGCCAGGCGTGTACGATATTC ACTCGCCGAACGTGCCGAGCGTCGAGTGGATTGAAGCCCTGCTGAAGAAGGCGGCACAGCGTATTCCGGCGCAACGCCTG TGGGTGAATCCGGACTGCGGTCTGAAAACTCGCGGTTGGCCGGAAACCCGCGCGGCGTTAGCGAACATGGTCAAAGCGGC GCACAATCTGCGTCAGGCGAAATAA
Upstream 100 bases:
>100_bases TTCAGTAAGCTCCTGGGGATGCGCTGTGTCGCCGCCTTCCTGCAAGCCGAACTATTTAGAGTTTTACTTTCAGATTCAAT AAAATAAGAGAGGAAGTAAA
Downstream 100 bases:
>100_bases CCCATCCTGGCCGCTGCGTTTATCCGACAGCAATGCGGCGCTACCTTTTGACGGGTAGCGCCCGTGTCTGACCTGATTAA CAGCGCCTCTTTCTTCTCAT
Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
Products: NA
Alternate protein names: Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme [H]
Number of amino acids: Translated: 754; Mature: 753
Protein sequence:
>754_residues MTILTHTLGFPRVGLRRELKKAQESYWAGNSTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNV PARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPV LLGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL TTYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINAIVGKRALWVA SSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAIT AQDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVL VHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILC WSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHT HMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRL WVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK
Sequences:
>Translated_754_residues MTILTHTLGFPRVGLRRELKKAQESYWAGNSTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNV PARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPV LLGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL TTYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINAIVGKRALWVA SSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAIT AQDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVL VHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILC WSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHT HMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRL WVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK >Mature_753_residues TILTHTLGFPRVGLRRELKKAQESYWAGNSTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVP ARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVL LGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLLT TYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINAIVGKRALWVAS SCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAITA QDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVLV HGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCW SFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTH MCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRLW VNPDCGLKTRGWPETRAALANMVKAAHNLRQAK
Specific function: Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation [H]
COG id: COG0620
COG function: function code E; Methionine synthase II (cobalamin-independent)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the vitamin-B12 independent methionine synthase family [H]
Homologues:
Organism=Escherichia coli, GI2367304, Length=753, Percent_Identity=94.1567065073041, Blast_Score=1464, Evalue=0.0, Organism=Saccharomyces cerevisiae, GI6320936, Length=767, Percent_Identity=48.109517601043, Blast_Score=713, Evalue=0.0,
Paralogues:
None
Copy number: 45,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013215 - InterPro: IPR006276 - InterPro: IPR002629 [H]
Pfam domain/function: PF08267 Meth_synt_1; PF01717 Meth_synt_2 [H]
EC number: =2.1.1.14 [H]
Molecular weight: Translated: 84631; Mature: 84500
Theoretical pI: Translated: 5.93; Mature: 5.93
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 0.9 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTILTHTLGFPRVGLRRELKKAQESYWAGNSTREALLAVGRELRARHWEQQKQAGIDLLP CEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE VGDFAWYDHVLTTSLLLGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFN CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCCCCCCCCHHHHHHHHHHC TNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDR CCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHCCCCCCHHH LTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH TTYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQRLPVDWLLSAGLINGRNVWRAD HHHHCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCCCHHH LTEKYAQINAIVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLR HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHCHHHHHH DALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAITAQDSQRENPYEVRAEAQRAR HHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC FKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVL EECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEE VHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYA EECCCCHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCCCCEEEECCCCCCCCEEHHHHHH QSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDE HHHCCCCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC PALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIAALDAD HHHHCCCCCCCCCHHHHHHHCCHHEEEEHHHCCCCCEEEHEEEEEEHHHHHHHHHHCCCC VITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRL EEEEECCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCHHHE WVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure TILTHTLGFPRVGLRRELKKAQESYWAGNSTREALLAVGRELRARHWEQQKQAGIDLLP EEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE VGDFAWYDHVLTTSLLLGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFN CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCCCCCCCCHHHHHHHHHHC TNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDR CCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHCCCCCCHHH LTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH TTYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQRLPVDWLLSAGLINGRNVWRAD HHHHCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCCCHHH LTEKYAQINAIVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLR HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHCHHHHHH DALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAITAQDSQRENPYEVRAEAQRAR HHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC FKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVL EECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEE VHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYA EECCCCHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCCCCEEEECCCCCCCCEEHHHHHH QSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDE HHHCCCCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC PALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIAALDAD HHHHCCCCCCCCCHHHHHHHCCHHEEEEHHHCCCCCEEEHEEEEEEHHHHHHHHHHCCCC VITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRL EEEEECCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCHHHE WVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA