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The map label for this gene is pepB [H]

Identifier: 194738288

GI number: 194738288

Start: 2677416

End: 2678699

Strand: Reverse

Name: pepB [H]

Synonym: SeSA_A2776

Alternate gene names: 194738288

Gene position: 2678699-2677416 (Counterclockwise)

Preceding gene: 194737775

Following gene: 194734306

Centisome position: 56.88

GC content: 56.46

Gene sequence:

>1284_bases
ATGACAGAAGCCATGAAAATTACGCTTTCCACGCAGCCTGCCGATGCGCGCTGGGGCGATAAAGCCACTTACAGTATTAA
TAACGACGGTATTACCTTGCATCTTAACGGTAAAGACGATCTGGGGTTGATCCAGCGTGCGGCGCGTAAAATCGACGGCC
TGGGAATAAAACAGGTCGCGCTGACAGGCGAAGGATGGGATACCGAGCGTTGTTGGGCATTCTGGGCGGGTTATAAAGGA
CCAAAAGGCGTCCGTACCGTAATGTGGCCGGATTTAGACGATGCCCAACGTCAGGAGCTGGATAACCGCCTGACCATTAT
TGACTGGGTGCGCGACACCATTAATGCTCCGGCGGAAGAGCTTGGGCCGGAGCAACTGGCGCAGCGCTCGGTGGATCTGC
TGTGTAGCGTCGCGTGCGATAGCGTCACTTACCGTATCACCAAAGGCGAAGATCTGCGCGAGCAGAACTATATGGGGTTG
CATACCGTAGGCCGTGGTTCTGAGCGTCCGCCGGTGCTGCTGGCGCTGGATTACAACCCGACGGGAGACAAAGATGCGCC
GGTTTATGCCTGCCTGGTCGGTAAAGGTATTACCTTTGACTCCGGCGGCTACAGTATCAAACAAAGCGCTTTTATGGACT
CAATGAAATCCGATATGGGCGGCGCGGCGACAGTAACAGGCGCGCTGGCGTTCGCCATTACCCGTGGGCTGAATAAACGC
GTAAAACTGTTCCTGTGCTGCGCCGATAATCTAATCAGCGGCAATGCGTTTAAACTGGGCGACATTATTCGCTACCGTAA
TGGTAAGAATGTCGAAGTCATGAATACCGATGCGGAAGGGCGACTGGTGCTGGCGGATGGCCTGATTGACGCCAGCGCAC
AACACCCGCAGCTAATCATTGATATGGCGACGTTAACCGGCGCGGCGAAAACAGCGCTGGGTAACGACTACCATGCGCTA
TTCAGTTTTGACGATACGCTGGCGGGGCGCTTGCTGACCAGCGCGGCGCAAGAGAATGAACCGTTCTGGCGTCTGCCGCT
GGCGGAGTTCCACCGTAACCAGCTGCCGTCTAACTTTGCGGAACTGAACAACACCGGCAGCGCGGCGTATCCCGCTGGGG
CAAGCACCGCCGCGGGTTTTCTGTCGCACTTTGTTGAAAATTACCGCGAAGGCTGGCTGCACATTGACTGTTCCGCCACT
TATCGCAAAGCGCCGGTTGAGCAGTGGGCTGCCGGGGCAACCGGTCTGGGTGTGCGCACCATCGCGAATTTGCTGACCGC
CTGA

Upstream 100 bases:

>100_bases
AAATTCTGGAGGCGATTCTGCTAGTCTGGTTGGATGAAGCAGAGTAAGTCAAATAACGGGCTGCCCTACGGCGGCCCGTT
TGCTAATAAGGAAAATAACA

Downstream 100 bases:

>100_bases
ACGGTGTTTTTGTAGGCCGGGTAAGCGAAGCGCCACCCGGCATTTTGCCTGATGGCGACGCCGTGCGTCTTATCAGGCCT
ACAACCCATATACATAATTT

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVALTGEGWDTERCWAFWAGYKG
PKGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEELGPEQLAQRSVDLLCSVACDSVTYRITKGEDLREQNYMGL
HTVGRGSERPPVLLALDYNPTGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKR
VKLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLIIDMATLTGAAKTALGNDYHAL
FSFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSAT
YRKAPVEQWAAGATGLGVRTIANLLTA

Sequences:

>Translated_427_residues
MTEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVALTGEGWDTERCWAFWAGYKG
PKGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEELGPEQLAQRSVDLLCSVACDSVTYRITKGEDLREQNYMGL
HTVGRGSERPPVLLALDYNPTGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKR
VKLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLIIDMATLTGAAKTALGNDYHAL
FSFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSAT
YRKAPVEQWAAGATGLGVRTIANLLTA
>Mature_426_residues
TEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVALTGEGWDTERCWAFWAGYKGP
KGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEELGPEQLAQRSVDLLCSVACDSVTYRITKGEDLREQNYMGLH
TVGRGSERPPVLLALDYNPTGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKRV
KLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLIIDMATLTGAAKTALGNDYHALF
SFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSATY
RKAPVEQWAAGATGLGVRTIANLLTA

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=317, Percent_Identity=37.8548895899054, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI47155554, Length=286, Percent_Identity=35.3146853146853, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI87082123, Length=427, Percent_Identity=91.5690866510539, Blast_Score=814, Evalue=0.0,
Organism=Escherichia coli, GI1790710, Length=318, Percent_Identity=38.3647798742138, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=327, Percent_Identity=31.8042813455657, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21357381, Length=342, Percent_Identity=32.1637426900585, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI221379063, Length=342, Percent_Identity=32.1637426900585, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI221379062, Length=342, Percent_Identity=32.1637426900585, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24662227, Length=322, Percent_Identity=30.1242236024845, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21355725, Length=289, Percent_Identity=29.757785467128, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24661038, Length=320, Percent_Identity=28.4375, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI161077148, Length=323, Percent_Identity=30.3405572755418, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20130057, Length=323, Percent_Identity=30.3405572755418, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20129969, Length=308, Percent_Identity=29.2207792207792, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355645, Length=292, Percent_Identity=27.7397260273973, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662223, Length=292, Percent_Identity=27.7397260273973, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI20129963, Length=317, Percent_Identity=29.6529968454259, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19922386, Length=311, Percent_Identity=27.6527331189711, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24646701, Length=271, Percent_Identity=28.4132841328413, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24646703, Length=271, Percent_Identity=28.4132841328413, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21358201, Length=271, Percent_Identity=28.4132841328413, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 46372; Mature: 46241

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVA
CCCEEEEEEECCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEE
LTGEGWDTERCWAFWAGYKGPKGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEE
EECCCCCCHHHHEEECCCCCCCCCEEEECCCCCHHHHHHHCCCEEHHHHHHHHHCCCHHH
LGPEQLAQRSVDLLCSVACDSVTYRITKGEDLREQNYMGLHTVGRGSERPPVLLALDYNP
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCCCEEECCCCCCCCCEEEEEECCC
TGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKR
CCCCCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCE
VKLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLII
EEEEEEECCCCCCCCCEEHHHHHEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEEE
DMATLTGAAKTALGNDYHALFSFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFA
EEHHHCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEECCHHHHHHHCCCCHHH
ELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSATYRKAPVEQWAAGATGLGVRT
HHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHCCCHHHHHCCCCCCHHHH
IANLLTA
HHHHHCC
>Mature Secondary Structure 
TEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVA
CCEEEEEEECCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEE
LTGEGWDTERCWAFWAGYKGPKGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEE
EECCCCCCHHHHEEECCCCCCCCCEEEECCCCCHHHHHHHCCCEEHHHHHHHHHCCCHHH
LGPEQLAQRSVDLLCSVACDSVTYRITKGEDLREQNYMGLHTVGRGSERPPVLLALDYNP
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCCCEEECCCCCCCCCEEEEEECCC
TGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKR
CCCCCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCE
VKLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLII
EEEEEEECCCCCCCCCEEHHHHHEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEEE
DMATLTGAAKTALGNDYHALFSFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFA
EEHHHCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEECCHHHHHHHCCCCHHH
ELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSATYRKAPVEQWAAGATGLGVRT
HHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHCCCHHHHHCCCCCCHHHH
IANLLTA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]