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The map label for this gene is fghA [H]

Identifier: 194738211

GI number: 194738211

Start: 2311908

End: 2312765

Strand: Direct

Name: fghA [H]

Synonym: SeSA_A2433

Alternate gene names: 194738211

Gene position: 2311908-2312765 (Clockwise)

Preceding gene: 194736993

Following gene: 194734716

Centisome position: 49.09

GC content: 56.88

Gene sequence:

>858_bases
ATGGAAATGCTCGAAGAGCACCGATGTTTTGGCGGCTGGCAGCAGCGCTGGCGTCATCATGCCGCCACGCTAAACTGCGC
CATGACATTCAGCATTTTTCTTCCGCCGACTCAGGATAATGAACCGCCTCCGGTACTGTACTGGTTGTCCGGGTTGACCT
GCAATGATGAGAACTTTACCACCAAAGCAGGCGCGCAGCGTATCGCAGCAGAACTGGGCATTGTATTGGTGATGCCGGAT
ACCAGTCCACGCGGTGAACAGGTCGCCAACGATAGCGGATACGATTTAGGCCACGGCGCCGGGTTTTATCTCAATGCCAC
ACAGCCGCCCTGGGCCAGCCATTATCGCATGTACGATTACCTGCGCGATGAGCTTCCGGCGCTCATCCAGACACAGTTTA
ACGTCAGCGACCGTTGCGCCATCAGCGGGCACTCGATGGGCGGCCACGGCGCGTTAATCATGGCGCTGAAAAATCCGGGC
AAATATACCAGCGTCTCTGCTTTTGCGCCCATCGTCAACCCCAGCCGCGTGCCGTGGGGAATCAAAGCGCTTACCGCTTA
TCTCGGCGAAGATGAATCAGCCTGGACTGAGTGGGATAGCTGCGAATTAATGCTGGCCAGCCAGCCGCAGGACGCCATTC
CTGTGCTCATCGATCAGGGCGACAGCGATCAATTCCTCGCCGATCAGCTTCAGCCCGCCGTACTGGCGGAAGCCGCGCGG
CAAACCGCCTGGCCGATGACGCTACGAATCCAACCAGGCTACGATCATAGCTATTATTTTATTGCGTCCTTCATCGAGGA
CCATCTGCGCTTTCATGCCCGGTATTTACGGGACGAGCGTGAGACGTCACCAACATAA

Upstream 100 bases:

>100_bases
TATGTATTACGGAAGTGAAAGTTACTCACAACGCGGTGAATAATCTGTATTATGAAGAATCTGCATACCTTATCAGGTTC
ACTATAAAAGGAGCCCCCGC

Downstream 100 bases:

>100_bases
TGAATTTTCCAGCGCCGCGCTGTAATTCACCTCCTCCGACTGCGGCGCGGAAGATTTATTATTTAAATCCGCGGCCTGCT
GGCGTACCTGAAGGCGGCCG

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFTTKAGAQRIAAELGIVLVMPD
TSPRGEQVANDSGYDLGHGAGFYLNATQPPWASHYRMYDYLRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPSRVPWGIKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
QTAWPMTLRIQPGYDHSYYFIASFIEDHLRFHARYLRDERETSPT

Sequences:

>Translated_285_residues
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFTTKAGAQRIAAELGIVLVMPD
TSPRGEQVANDSGYDLGHGAGFYLNATQPPWASHYRMYDYLRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPSRVPWGIKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
QTAWPMTLRIQPGYDHSYYFIASFIEDHLRFHARYLRDERETSPT
>Mature_285_residues
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFTTKAGAQRIAAELGIVLVMPD
TSPRGEQVANDSGYDLGHGAGFYLNATQPPWASHYRMYDYLRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPSRVPWGIKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
QTAWPMTLRIQPGYDHSYYFIASFIEDHLRFHARYLRDERETSPT

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=51.7857142857143, Blast_Score=306, Evalue=1e-83,
Organism=Escherichia coli, GI1788477, Length=276, Percent_Identity=88.4057971014493, Blast_Score=506, Evalue=1e-145,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=53.4296028880866, Blast_Score=324, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17510185, Length=280, Percent_Identity=47.5, Blast_Score=253, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=44.2567567567568, Blast_Score=246, Evalue=3e-66,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=48.4098939929329, Blast_Score=264, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=48.4098939929329, Blast_Score=263, Evalue=9e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31971; Mature: 31971

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFT
CCHHHHHHCCCCHHHHHHHHHHEEEEEEEEEEEECCCCCCCCCCEEEEECCEEECCCCCC
TKAGAQRIAAELGIVLVMPDTSPRGEQVANDSGYDLGHGAGFYLNATQPPWASHYRMYDY
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPSRVPWG
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCHH
IKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
HHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCHHHHHHCCHHHHHHHHH
QTAWPMTLRIQPGYDHSYYFIASFIEDHLRFHARYLRDERETSPT
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFT
CCHHHHHHCCCCHHHHHHHHHHEEEEEEEEEEEECCCCCCCCCCEEEEECCEEECCCCCC
TKAGAQRIAAELGIVLVMPDTSPRGEQVANDSGYDLGHGAGFYLNATQPPWASHYRMYDY
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPSRVPWG
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCHH
IKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
HHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCHHHHHHCCHHHHHHHHH
QTAWPMTLRIQPGYDHSYYFIASFIEDHLRFHARYLRDERETSPT
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA