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The map label for this gene is macA [H]

Identifier: 194738152

GI number: 194738152

Start: 1029012

End: 1030130

Strand: Direct

Name: macA [H]

Synonym: SeSA_A1059

Alternate gene names: 194738152

Gene position: 1029012-1030130 (Clockwise)

Preceding gene: 194737327

Following gene: 194734135

Centisome position: 21.85

GC content: 53.26

Gene sequence:

>1119_bases
ATGCGTGCTAAGGGAAAGAAATTTAAAAAGCGTTATCTGGCCATTATTTTAATTCTTTTAGTGGGGGGGATGGTTAGCTG
GCGAATGATAAATGCGCCGCTGCCAACTTATCAGACATTAATCGTGCGGCCAGGCGATCTTGAACAGAGTGTACTGGCGA
CTGGAAAACTGGACGCGTTGCGTAAAGTGGATGTCGGCGCGCAAGTGAGCGGCCAGTTGAAAACGCTGCTGGTCTCCATT
GGAGATAACGTTAAAAAAGATCAGCTACTCGGCGTGATTGACCCAGATCAGGCGGAGAACCAGATAAAAGAGGTCGAGGC
CACCCTGATGGAGCTGAACGCGGAGCGTCAGCAGGCAGCCGCTGAGTTAAAGCTGGCGCGGGTTACGCTGGCGCGCCAGC
AGCAGTTAGCTAAGACTCAGGCGGTATCGCAACAGGATCTGGATACCGCGGCGACGGAGATGGCGGTTAAACAGGCGCGT
ATTGGCACCATAGATGCCCAGATCAAACGTAATCGGGCCTCGTTGGACACCGCGAAAACCAACCTGGAATATACCCGTAT
TGTTGCCCCCATGGCGGGGGAAGTGACGCAAATCACTACCCTGCAAGGACAAACGGTGATTGCAGCTCAGCAGGCGCCCA
ATATTCTGACGCTGGCGGATATGAGCACCATGCTGGTAAAAGCGCAGGTCTCGGAAGCGGACGTGATCCATCTTCGGGCG
GGGCAGAAAGCATGGTTCACCATTGCAGGCGATCCGCAAACGCGCTATGAAGGCGTTTTAAAAGATATTCTGCCGACGCC
GGAAAAGGTCAACGACGCTATTTTTTATTACGCCCGGTTTGAAGTGCCGAATCCCAAAAGAATCTTGCGTCTTGATATGA
CCGCACAGGTTTATATTCAACTCATGGATGTCAAAAATGTGCTGATTATTCCTCTCGCCGCGCTTGGCGAACCGGTGGGC
GGCAATCGTTATAAAGTGGCGCTGTTGCGTAACGGCGAAAAACGTGAGCGCGAAGTGGTCATTGGCGAGCGTAACGATAC
AGACGTGGAAGTGGTTAAAGGTCTGGAAGCGGGCGATGAGGTGATCATCGGCGAGAGCAGGCCAGGAGCGGCGCCATGA

Upstream 100 bases:

>100_bases
ACATTAACCAATCGTCAATACAGCCGACGCTATCTTTATTGTGTCAGGTTTGTTTAGATACGGTTTACTTTCTGGTTAAA
ATTTTGCCGTCAGGGTTTCT

Downstream 100 bases:

>100_bases
CAGCATTGCTTGAACTGCGCAATGTGAGTCGCAGCTACCCCTCAGGAGAAGAGCAGGTGGCGGTGTTAAAAGATATCTCC
CTGCAAATCCACGCCGGGGA

Product: macrolide transporter subunit MacA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MRAKGKKFKKRYLAIILILLVGGMVSWRMINAPLPTYQTLIVRPGDLEQSVLATGKLDALRKVDVGAQVSGQLKTLLVSI
GDNVKKDQLLGVIDPDQAENQIKEVEATLMELNAERQQAAAELKLARVTLARQQQLAKTQAVSQQDLDTAATEMAVKQAR
IGTIDAQIKRNRASLDTAKTNLEYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLRA
GQKAWFTIAGDPQTRYEGVLKDILPTPEKVNDAIFYYARFEVPNPKRILRLDMTAQVYIQLMDVKNVLIIPLAALGEPVG
GNRYKVALLRNGEKREREVVIGERNDTDVEVVKGLEAGDEVIIGESRPGAAP

Sequences:

>Translated_372_residues
MRAKGKKFKKRYLAIILILLVGGMVSWRMINAPLPTYQTLIVRPGDLEQSVLATGKLDALRKVDVGAQVSGQLKTLLVSI
GDNVKKDQLLGVIDPDQAENQIKEVEATLMELNAERQQAAAELKLARVTLARQQQLAKTQAVSQQDLDTAATEMAVKQAR
IGTIDAQIKRNRASLDTAKTNLEYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLRA
GQKAWFTIAGDPQTRYEGVLKDILPTPEKVNDAIFYYARFEVPNPKRILRLDMTAQVYIQLMDVKNVLIIPLAALGEPVG
GNRYKVALLRNGEKREREVVIGERNDTDVEVVKGLEAGDEVIIGESRPGAAP
>Mature_372_residues
MRAKGKKFKKRYLAIILILLVGGMVSWRMINAPLPTYQTLIVRPGDLEQSVLATGKLDALRKVDVGAQVSGQLKTLLVSI
GDNVKKDQLLGVIDPDQAENQIKEVEATLMELNAERQQAAAELKLARVTLARQQQLAKTQAVSQQDLDTAATEMAVKQAR
IGTIDAQIKRNRASLDTAKTNLEYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLRA
GQKAWFTIAGDPQTRYEGVLKDILPTPEKVNDAIFYYARFEVPNPKRILRLDMTAQVYIQLMDVKNVLIIPLAALGEPVG
GNRYKVALLRNGEKREREVVIGERNDTDVEVVKGLEAGDEVIIGESRPGAAP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=368, Percent_Identity=83.695652173913, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI87082036, Length=346, Percent_Identity=26.5895953757225, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789929, Length=383, Percent_Identity=22.4543080939948, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40792; Mature: 40792

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKGKKFKKRYLAIILILLVGGMVSWRMINAPLPTYQTLIVRPGDLEQSVLATGKLDAL
CCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCEEEEECCCCCCHHHHHCCCHHHH
RKVDVGAQVSGQLKTLLVSIGDNVKKDQLLGVIDPDQAENQIKEVEATLMELNAERQQAA
HHCCCCCCCCCHHHHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHH
AELKLARVTLARQQQLAKTQAVSQQDLDTAATEMAVKQARIGTIDAQIKRNRASLDTAKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHCHHHHC
NLEYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLRA
CCEEEEEECCCCCCCEEEEEECCCEEEEECCCCCEEEEHHHHHHHEEEECCCCCEEEEEC
GQKAWFTIAGDPQTRYEGVLKDILPTPEKVNDAIFYYARFEVPNPKRILRLDMTAQVYIQ
CCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEECCHHEEEEE
LMDVKNVLIIPLAALGEPVGGNRYKVALLRNGEKREREVVIGERNDTDVEVVKGLEAGDE
EECCCCEEEEEHHHHCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHCCCCCCE
VIIGESRPGAAP
EEEECCCCCCCC
>Mature Secondary Structure
MRAKGKKFKKRYLAIILILLVGGMVSWRMINAPLPTYQTLIVRPGDLEQSVLATGKLDAL
CCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCEEEEECCCCCCHHHHHCCCHHHH
RKVDVGAQVSGQLKTLLVSIGDNVKKDQLLGVIDPDQAENQIKEVEATLMELNAERQQAA
HHCCCCCCCCCHHHHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHH
AELKLARVTLARQQQLAKTQAVSQQDLDTAATEMAVKQARIGTIDAQIKRNRASLDTAKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHCHHHHC
NLEYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLRA
CCEEEEEECCCCCCCEEEEEECCCEEEEECCCCCEEEEHHHHHHHEEEECCCCCEEEEEC
GQKAWFTIAGDPQTRYEGVLKDILPTPEKVNDAIFYYARFEVPNPKRILRLDMTAQVYIQ
CCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEECCHHEEEEE
LMDVKNVLIIPLAALGEPVGGNRYKVALLRNGEKREREVVIGERNDTDVEVVKGLEAGDE
EECCCCEEEEEHHHHCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHCCCCCCE
VIIGESRPGAAP
EEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]