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The map label for this gene is dlgD [H]

Identifier: 194738073

GI number: 194738073

Start: 3733833

End: 3734831

Strand: Direct

Name: dlgD [H]

Synonym: SeSA_A3866

Alternate gene names: 194738073

Gene position: 3733833-3734831 (Clockwise)

Preceding gene: 194738090

Following gene: 194736199

Centisome position: 79.29

GC content: 55.86

Gene sequence:

>999_bases
ATGAAAGTAACTTTCGAAGAGTTAAAAGGGGCCTTCTACCGCGTCTTGCGGTCGCGGAATATTGCGGAAGATACCGCCGA
CGCCTGCGCGGAAATGTTCGCTCGCACCACCGAGTCCGGTGTCTATTCCCACGGCGTGAACCGCTTTCCCCGCTTCATTC
AGCAACTAGATAACGGCGACATTATTCCTGATGCTAAACCGCAGCGGGTTACCAGCCTCGGCGCCATCGAACAGTGGGAT
GCTCAGCGCGCTATCGGCAACCTGACGGCGAAAAAGATGATGGACCGGGCCATCGAGCTGGCTTCCGATCATGGTATTGG
CCTGGTGGCGTTACGTAATGCTAACCACTGGATGCGCGGCGGCAGCTACGGCTGGCAGGCGGCGGAAAAAGGCTATATCG
GCATTTGCTGGACCAACTCCATCGCCGTCATGCCGCCGTGGGGCGCGAAAGAGTGCCGTATCGGTACCAATCCGTTGATC
GTCGCCATCCCGTCTACGCCGATCACTATGGTAGATATGTCGATGTCGATGTTCTCTTACGGCATGCTGGAGGTTAACCG
CCTGGCCGGCCGCGAACTGCCGGTGGACGGCGGTTTCGACGATAACGGTCAGTTGACCAAAGAACCGGGCGTTATCGAGA
AAAATCGCCGCATTTTACCGATGGGTTACTGGAAAGGATCTGGTCTGTCGATTGTGCTGGACATGATTGCCACCCTGCTT
TCCAACGGCTCTTCCGTTGCCGAAGTGACCCAGGAAAACAGCGATGAATATGGCGTTTCGCAGATCTTCATCGCCATAGA
AGTGGATAAGCTGATCGATGGCGCAACCCGCGATGCCAAACTGCAGCGGATTATGGATTTCATCACCACCGCTGAACGTG
CTGACGACAACGTCGCGATTCGGCTGCCCGGCCACGAATTTACCAAATTGCTGGATGACAACCGCCGTCACGGTATCACC
ATTGACGACAGCGTCTGGGCCAAAATTCAGGCGCTGTAA

Upstream 100 bases:

>100_bases
TCAATTTTTGATCTATATATTTGGAACTACATTTCGTATTATGAAATTTATCGACAAAAAAACATACTAAAATTTCTAAC
AATCGACCAGGAGAACAGGG

Downstream 100 bases:

>100_bases
GGAGCCACATCATGATTTTTGGACATATCGCGCAGCCAAATCCATGTCATTTGCCAGCCGCGATCGAGAAAGCGCTTCAC
TTTTTACGTACCACCGACTT

Product: 2,3-diketo-L-gulonate reductase

Products: NA

Alternate protein names: 2,3-DKG reductase; 3-dehydro-L-gulonate 2-dehydrogenase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKVTFEELKGAFYRVLRSRNIAEDTADACAEMFARTTESGVYSHGVNRFPRFIQQLDNGDIIPDAKPQRVTSLGAIEQWD
AQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLI
VAIPSTPITMVDMSMSMFSYGMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLL
SNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAIRLPGHEFTKLLDDNRRHGIT
IDDSVWAKIQAL

Sequences:

>Translated_332_residues
MKVTFEELKGAFYRVLRSRNIAEDTADACAEMFARTTESGVYSHGVNRFPRFIQQLDNGDIIPDAKPQRVTSLGAIEQWD
AQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLI
VAIPSTPITMVDMSMSMFSYGMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLL
SNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAIRLPGHEFTKLLDDNRRHGIT
IDDSVWAKIQAL
>Mature_332_residues
MKVTFEELKGAFYRVLRSRNIAEDTADACAEMFARTTESGVYSHGVNRFPRFIQQLDNGDIIPDAKPQRVTSLGAIEQWD
AQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLI
VAIPSTPITMVDMSMSMFSYGMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLL
SNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAIRLPGHEFTKLLDDNRRHGIT
IDDSVWAKIQAL

Specific function: Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate [H]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790000, Length=332, Percent_Identity=89.7590361445783, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1787020, Length=331, Percent_Identity=25.0755287009063, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786727, Length=244, Percent_Identity=27.0491803278689, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17507179, Length=332, Percent_Identity=25.6024096385542, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17536633, Length=298, Percent_Identity=24.1610738255034, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667904, Length=265, Percent_Identity=26.4150943396226, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667908, Length=265, Percent_Identity=26.4150943396226, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45553211, Length=265, Percent_Identity=26.4150943396226, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667912, Length=265, Percent_Identity=26.4150943396226, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24658010, Length=279, Percent_Identity=25.4480286738351, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24648360, Length=264, Percent_Identity=26.8939393939394, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.130 [H]

Molecular weight: Translated: 36713; Mature: 36713

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTFEELKGAFYRVLRSRNIAEDTADACAEMFARTTESGVYSHGVNRFPRFIQQLDNGD
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
IIPDAKPQRVTSLGAIEQWDAQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRG
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHCC
GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY
CCCCCHHCCCCEEEEEEECCEEEECCCCCCCCEECCCCEEEEECCCCEEEEHHHHHHHHH
GMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLL
HHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
SNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAI
CCCCHHHHHHHCCCCCCCCEEEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEE
RLPGHEFTKLLDDNRRHGITIDDSVWAKIQAL
EECCHHHHHHHCCCCCCCEEECCHHHEEEECC
>Mature Secondary Structure
MKVTFEELKGAFYRVLRSRNIAEDTADACAEMFARTTESGVYSHGVNRFPRFIQQLDNGD
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
IIPDAKPQRVTSLGAIEQWDAQRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRG
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHCC
GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY
CCCCCHHCCCCEEEEEEECCEEEECCCCCCCCEECCCCEEEEECCCCEEEEHHHHHHHHH
GMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLL
HHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
SNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAI
CCCCHHHHHHHCCCCCCCCEEEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEE
RLPGHEFTKLLDDNRRHGITIDDSVWAKIQAL
EECCHHHHHHHCCCCCCCEEECCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA