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The map label for this gene is ggt [H]

Identifier: 194738047

GI number: 194738047

Start: 3604411

End: 3606153

Strand: Reverse

Name: ggt [H]

Synonym: SeSA_A3742

Alternate gene names: 194738047

Gene position: 3606153-3604411 (Counterclockwise)

Preceding gene: 194735739

Following gene: 194734542

Centisome position: 76.58

GC content: 55.31

Gene sequence:

>1743_bases
ATGAAACCAACGTTTATGCGCTGGGTGGCGATCGCCGCTCTGCTGGCCGGGGGGACGTTTAGCGCGGTGGCCAATCCTCC
CGTCGCGCCGCCAGTCTCCTATGGTGTTGAAGAAGATGTCTTTCATCCTGTGCGGGCGACGCAAGGGATGGTGGCCTCGG
TGGATGCAATGGCGACGCAGGTTGGCGTGGATATCTTAAAGCAGGGCGGTAATGCCGTGGATGCCGCCGTCGCCGTGGGC
TATGCGCTGGCTGTGACGCATCCGCAAGCCGGGAATCTGGGCGGCGGGGGTTTTATGCTGCTGCGCACTAAAGATGGCGC
TACCACGGCGATTGATTTTCGTGAAATGGCGCCTGCTGGCGCGACCCGTGATATGTTCCTCGACGAGCAGGGTAACGCCG
ATGCGAAAAAGTCGCTGACGTCGCATCTGGCATCCGGTACGCCGGGTACCGTGGCGGGGTTCTCGCTGGCGCTGGAGAAA
TACGGCACGATGCCGCTGAATAAAGTGGTGCGTCCGGCGATGAAGCTGGCGGAAGAGGGTTTTGTGGTTAACGATGCGCT
GGCCGACGACTTAAAAACTTACGGCAGCGAAGTGATCCCCAACCATGAGAACAGCAAAGCCATTTTCTGGAAAGACAGCG
AGCCGCTGAAAAAAGGCGATAAGCTGGTCCAGAAGAATCTGGCGAAAAGCCTGGAAATGATTGCCGAAAACGGCCCGGAT
GCGTTTTATAAAGGGGCGATTGCTGACCAGATTGCCGGGGAAATGCACAAGAACGGCGGTCTGATGACCAAAGAGGATTT
AGCCAGCTATAAAGCCGTTGAGCGTACGCCAATCAGCGGTGACTATCGCGGGTATCAGGTCTTCTCCATGCCGCCGCCAT
CCTCGGGCGGTATTCACATCGTGCAAATTCTCAATATCCTTGAAAATTTCGACATGAAGAAGTACGGCTTTGGCAGCGCC
GATGCCATGCAAATCATGGCGGAAGCGGAAAAATATGCCTACGCTGACCGCTCAGAGTATCTGGGCGATCCGGACTTTGT
GAAAGTGCCGTGGCAGGCGCTGACCCACAAAGCCTATGCAAAAACGTTGGCCGATCAAATTGATATTAATAAGGCAAAAC
CTTCCAGTCAGATCAAACCGGGCAAGCTCGCCCCGTATGAAAGCAACCAGACCACCCACTTCTCGGTGGTGGATAAAGAC
GGCAATGCTGTGGCGGTGACCTATACCCTGAACACCACCTTCGGCACAGGAATTGTGGCGGGAAATACCGGTATTCTGCT
GAATAATCAAATGGATGATTTTTCTGCTAAACCCGGTGTACCTAATGTTTATGGCCTGGTGGGCGGCGATGCTAACGCGG
TCGGTCCGAAGAAGCGTCCGCTGTCGTCGATGTCGCCGACTATCGTCGTTAAAGATGGCAAAACCTGGCTGGTGACCGGC
AGTCCTGGTGGGAGTCGAATCATCACTACCGTGCTGCAAATGGTAGTGAACAGCATTGATTTCGGCATGAACGTCGCCGA
AGCGACCAACGCGCCGCGTTTCCATCATCAATGGTTGCCGGACGAACTGCGGGTAGAAAAGGGCTTCAGCCCCGATACGC
TAAAGTTGCTGGAACAGAAAGGGCAGAAAGTCGCGCTGAAAGAAGCGATGGGCAGTACCCAAAGTATTATGGTTGGCCCG
GATGGCGAACTGTACGGTGCGTCTGACCCGCGTTCGGTGGATGATTTAACGGCGGGATACTGA

Upstream 100 bases:

>100_bases
TTTTTAAGTGTACCTCTATTTCGCCATGATGATGATTTTTTAAGCGTTGTGGACCAGGATTAAACGGGACATACACCCAT
TCATCTGGAGAAAAACAACG

Downstream 100 bases:

>100_bases
TTTTTAATTCCAGGCCCGGTGTCAGACACCGGGCTATTTGCAGATTATGCCGTGAGTAATCGGGCTGGATTATCAATACA
AAGCTTGCGCAGAGTATCCT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAGATRDMFLDEQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALADDLKTYGSEVIPNHENSKAIFWKDSEPLKKGDKLVQKNLAKSLEMIAENGPD
AFYKGAIADQIAGEMHKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Sequences:

>Translated_580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAGATRDMFLDEQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALADDLKTYGSEVIPNHENSKAIFWKDSEPLKKGDKLVQKNLAKSLEMIAENGPD
AFYKGAIADQIAGEMHKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY
>Mature_580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAGATRDMFLDEQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALADDLKTYGSEVIPNHENSKAIFWKDSEPLKKGDKLVQKNLAKSLEMIAENGPD
AFYKGAIADQIAGEMHKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=534, Percent_Identity=32.3970037453184, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915090, Length=534, Percent_Identity=32.3970037453184, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915096, Length=534, Percent_Identity=32.3970037453184, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915094, Length=534, Percent_Identity=32.3970037453184, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI113429324, Length=534, Percent_Identity=31.0861423220974, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI113429326, Length=538, Percent_Identity=30.2973977695167, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=31.511839708561, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI153266901, Length=553, Percent_Identity=29.4755877034358, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI153266885, Length=554, Percent_Identity=29.4223826714801, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI153266907, Length=553, Percent_Identity=27.4864376130199, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=34.703196347032, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=34.703196347032, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=31.5068493150685, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1789856, Length=580, Percent_Identity=90.8620689655172, Blast_Score=1071, Evalue=0.0,
Organism=Caenorhabditis elegans, GI212646519, Length=575, Percent_Identity=33.7391304347826, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI72000294, Length=575, Percent_Identity=33.7391304347826, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI193208247, Length=556, Percent_Identity=32.1942446043165, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI193208245, Length=556, Percent_Identity=32.1942446043165, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=530, Percent_Identity=34.1509433962264, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17506189, Length=552, Percent_Identity=30.2536231884058, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.765237020316, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI72001497, Length=223, Percent_Identity=26.457399103139, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=223, Percent_Identity=26.457399103139, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=495, Percent_Identity=30.3030303030303, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45551474, Length=542, Percent_Identity=32.1033210332103, Blast_Score=252, Evalue=6e-67,
Organism=Drosophila melanogaster, GI161077880, Length=542, Percent_Identity=32.1033210332103, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI161077878, Length=542, Percent_Identity=32.1033210332103, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24642670, Length=542, Percent_Identity=32.1033210332103, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24642666, Length=542, Percent_Identity=32.1033210332103, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=30.5343511450382, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.5019305019305, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI18859741, Length=547, Percent_Identity=28.7020109689214, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61718; Mature: 61718

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQ
CCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCHHHCCHHHHHCCHHHHHHHHHHH
VGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAG
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCCCCEEEEHHHHCCCC
ATRDMFLDEQGNADAKKSLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVRPAMKLAEEG
CCCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FVVNDALADDLKTYGSEVIPNHENSKAIFWKDSEPLKKGDKLVQKNLAKSLEMIAENGPD
CEEEHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AFYKGAIADQIAGEMHKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKDGKTWLVTG
CCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC
>Mature Secondary Structure
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQ
CCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCHHHCCHHHHHCCHHHHHHHHHHH
VGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAG
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCCCCEEEEHHHHCCCC
ATRDMFLDEQGNADAKKSLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVRPAMKLAEEG
CCCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FVVNDALADDLKTYGSEVIPNHENSKAIFWKDSEPLKKGDKLVQKNLAKSLEMIAENGPD
CEEEHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AFYKGAIADQIAGEMHKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKDGKTWLVTG
CCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]