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The map label for this gene is mdtD [H]

Identifier: 194738025

GI number: 194738025

Start: 2243269

End: 2244681

Strand: Direct

Name: mdtD [H]

Synonym: SeSA_A2366

Alternate gene names: 194738025

Gene position: 2243269-2244681 (Clockwise)

Preceding gene: 194735845

Following gene: 194737114

Centisome position: 47.64

GC content: 54.42

Gene sequence:

>1413_bases
ATGACAGAACTTCCTGACAACACCCGCTGGCAACTCTGGATTGTGGCATTCGGCTTTTTTATGCAGTCGCTGGATACCAC
CATCGTCAACACTGCGCTGCCCTCCATGGCGAAAAGCCTGGGGGAAAGCCCGCTGCATATGCACATGGTAGTGGTGTCAT
ATGTTCTTACCGTCGCCGTAATGCTCCCCGCCAGCGGCTGGCTGGCAGATAAAATCGGCGTGCGTAATATCTTCTTTGCC
GCCATTGTGCTGTTCACGCTGGGTTCGCTGTTTTGCGCCCTCTCCGGCACGCTTAATCAACTGGTATTAGCGCGGGTTTT
ACAAGGCGTAGGCGGCGCGATGATGGTACCGGTCGGACGCCTGACGGTCATGAAAATCGTGCCGCGCGCGCAATATATGG
CGGCGATGACCTTCGTCACCCTACCGGGACAGATCGGGCCGTTACTCGGCCCCGCGCTGGGCGGGGTGCTGGTGGAATAT
GCTTCATGGCACTGGATCTTTCTGATCAATATCCCGGTGGGAATTGTCGGCGCTATTGCAACCTTTATGCTGATGCCAAA
CTACACCATAGAGACCCGGCGCTTTGATCTGCCGGGGTTCCTGCTGTTAGCTATCGGCATGGCGGTACTCACGCTGGCGC
TGGATGGTAGTAAAAGCATGGGGATTTCGCCCTGGACATTAGCCGGACTTGCTGCGGGCGGCGCGGCAGCCATTCTGCTC
TATCTCCTCCATGCCAAAAAAAACTCAGGCGCGTTATTCAGCCTGCGATTGTTCCGCACGCCCACGTTTTCACTGGGGTT
GCTGGGCAGTTTTGCCGGGCGTATCGGCAGCGGTATGCTGCCGTTTATGACGCCGGTCTTTTTGCAAATTGGTCTTGGTT
TTTCACCGTTTCATGCCGGTTTGATGATGATCCCCATGGTGCTGGGCAGCATGGGAATGAAGCGGATTGTGGTGCAGATA
GTTAACCGTTTTGGCTATCGTCGGGTTCTGGTGGCGACCACGCTCGGACTGGCATTGGTTAGCCTGTTGTTTATGTCGGT
CGCGCTGCTCGGCTGGTATTATCTCCTGCCGCTGGTACTGCTTTTGCAGGGAATGGTGAACTCGGCGCGCTTTTCTTCCA
TGAACACCTTAACGCTAAAAGACCTTCCCGATACGCTGGCCAGCAGCGGCAATAGCTTATTATCGATGATTATGCAGCTC
TCGATGAGTATTGGCGTCACTATTGCCGGAATGCTGCTGGGTATGTTTGGCCAACAGCATATCGGGATAGACAGTAGCGC
CACACATCACGTCTTTATGTACACCTGGTTATGTATGGCGGTTATTATCGCGCTACCGGCGATAATTTTTGCCCGCGTGC
CGAACGATACACAGCAAAACATGGTCATTTCACGGCGTAAAAGGAGCCTGTAA

Upstream 100 bases:

>100_bases
GCCAGCTCCTGACGCTCTATACCACGCCGGTGGTGTACCTCTTTTTCGATCGTCTGCGGCGGCGTTTTTCGCGTAAAAAT
AGCAAACCGGTAGTAGAAAT

Downstream 100 bases:

>100_bases
TGAAAGTCTGGCGGCCCGGAATCACCGGCAAGCTGTTTCTGGCGATTTTCGCCACCTGCATCGTGCTGCTGATCAGTATG
CATTGGGCCGTGCGCGTCAG

Product: multidrug efflux system protein MdtE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTELPDNTRWQLWIVAFGFFMQSLDTTIVNTALPSMAKSLGESPLHMHMVVVSYVLTVAVMLPASGWLADKIGVRNIFFA
AIVLFTLGSLFCALSGTLNQLVLARVLQGVGGAMMVPVGRLTVMKIVPRAQYMAAMTFVTLPGQIGPLLGPALGGVLVEY
ASWHWIFLINIPVGIVGAIATFMLMPNYTIETRRFDLPGFLLLAIGMAVLTLALDGSKSMGISPWTLAGLAAGGAAAILL
YLLHAKKNSGALFSLRLFRTPTFSLGLLGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQI
VNRFGYRRVLVATTLGLALVSLLFMSVALLGWYYLLPLVLLLQGMVNSARFSSMNTLTLKDLPDTLASSGNSLLSMIMQL
SMSIGVTIAGMLLGMFGQQHIGIDSSATHHVFMYTWLCMAVIIALPAIIFARVPNDTQQNMVISRRKRSL

Sequences:

>Translated_470_residues
MTELPDNTRWQLWIVAFGFFMQSLDTTIVNTALPSMAKSLGESPLHMHMVVVSYVLTVAVMLPASGWLADKIGVRNIFFA
AIVLFTLGSLFCALSGTLNQLVLARVLQGVGGAMMVPVGRLTVMKIVPRAQYMAAMTFVTLPGQIGPLLGPALGGVLVEY
ASWHWIFLINIPVGIVGAIATFMLMPNYTIETRRFDLPGFLLLAIGMAVLTLALDGSKSMGISPWTLAGLAAGGAAAILL
YLLHAKKNSGALFSLRLFRTPTFSLGLLGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQI
VNRFGYRRVLVATTLGLALVSLLFMSVALLGWYYLLPLVLLLQGMVNSARFSSMNTLTLKDLPDTLASSGNSLLSMIMQL
SMSIGVTIAGMLLGMFGQQHIGIDSSATHHVFMYTWLCMAVIIALPAIIFARVPNDTQQNMVISRRKRSL
>Mature_469_residues
TELPDNTRWQLWIVAFGFFMQSLDTTIVNTALPSMAKSLGESPLHMHMVVVSYVLTVAVMLPASGWLADKIGVRNIFFAA
IVLFTLGSLFCALSGTLNQLVLARVLQGVGGAMMVPVGRLTVMKIVPRAQYMAAMTFVTLPGQIGPLLGPALGGVLVEYA
SWHWIFLINIPVGIVGAIATFMLMPNYTIETRRFDLPGFLLLAIGMAVLTLALDGSKSMGISPWTLAGLAAGGAAAILLY
LLHAKKNSGALFSLRLFRTPTFSLGLLGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQIV
NRFGYRRVLVATTLGLALVSLLFMSVALLGWYYLLPLVLLLQGMVNSARFSSMNTLTLKDLPDTLASSGNSLLSMIMQLS
MSIGVTIAGMLLGMFGQQHIGIDSSATHHVFMYTWLCMAVIIALPAIIFARVPNDTQQNMVISRRKRSL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1788392, Length=469, Percent_Identity=86.5671641791045, Blast_Score=780, Evalue=0.0,
Organism=Escherichia coli, GI1790195, Length=459, Percent_Identity=45.5337690631808, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1789042, Length=401, Percent_Identity=27.6807980049875, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788710, Length=422, Percent_Identity=27.4881516587678, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081983, Length=425, Percent_Identity=28.2352941176471, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319770, Length=289, Percent_Identity=27.681660899654, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322958, Length=174, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=30.6666666666667, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323735, Length=164, Percent_Identity=28.0487804878049, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=125, Percent_Identity=31.2, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50729; Mature: 50598

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELPDNTRWQLWIVAFGFFMQSLDTTIVNTALPSMAKSLGESPLHMHMVVVSYVLTVAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MLPASGWLADKIGVRNIFFAAIVLFTLGSLFCALSGTLNQLVLARVLQGVGGAMMVPVGR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHH
LTVMKIVPRAQYMAAMTFVTLPGQIGPLLGPALGGVLVEYASWHWIFLINIPVGIVGAIA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
TFMLMPNYTIETRRFDLPGFLLLAIGMAVLTLALDGSKSMGISPWTLAGLAAGGAAAILL
HHHHCCCCEEECEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHH
YLLHAKKNSGALFSLRLFRTPTFSLGLLGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAG
HHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
LMMIPMVLGSMGMKRIVVQIVNRFGYRRVLVATTLGLALVSLLFMSVALLGWYYLLPLVL
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLQGMVNSARFSSMNTLTLKDLPDTLASSGNSLLSMIMQLSMSIGVTIAGMLLGMFGQQH
HHHHHHHHHHHCCCCEEEHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IGIDSSATHHVFMYTWLCMAVIIALPAIIFARVPNDTQQNMVISRRKRSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TELPDNTRWQLWIVAFGFFMQSLDTTIVNTALPSMAKSLGESPLHMHMVVVSYVLTVAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MLPASGWLADKIGVRNIFFAAIVLFTLGSLFCALSGTLNQLVLARVLQGVGGAMMVPVGR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHH
LTVMKIVPRAQYMAAMTFVTLPGQIGPLLGPALGGVLVEYASWHWIFLINIPVGIVGAIA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
TFMLMPNYTIETRRFDLPGFLLLAIGMAVLTLALDGSKSMGISPWTLAGLAAGGAAAILL
HHHHCCCCEEECEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHH
YLLHAKKNSGALFSLRLFRTPTFSLGLLGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAG
HHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
LMMIPMVLGSMGMKRIVVQIVNRFGYRRVLVATTLGLALVSLLFMSVALLGWYYLLPLVL
HHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLQGMVNSARFSSMNTLTLKDLPDTLASSGNSLLSMIMQLSMSIGVTIAGMLLGMFGQQH
HHHHHHHHHHHCCCCEEEHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IGIDSSATHHVFMYTWLCMAVIIALPAIIFARVPNDTQQNMVISRRKRSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA