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The map label for this gene is cyoE [H]

Identifier: 194737863

GI number: 194737863

Start: 501479

End: 502366

Strand: Reverse

Name: cyoE [H]

Synonym: SeSA_A0497

Alternate gene names: 194737863

Gene position: 502366-501479 (Counterclockwise)

Preceding gene: 194737366

Following gene: 194734000

Centisome position: 10.67

GC content: 53.49

Gene sequence:

>888_bases
ATGTTTAAGCAATACCTGCAAGTAACGAAACCAGGCATCATCTTTGGCAACCTGATCTCGGTGATCGGGGGATTTCTGCT
GGCCTCAAAGGGCAGCATTGACTATCCCCTGTTCATTTATACGCTGGTCGGGGTGTCACTGGTTGTGGCGTCGGGTTGTG
TATTTAACAACTACATCGACAGGGATATCGACAGGAAGATGGAAAGGACCAAGAATCGGGTGCTGGTTAAAGGCCTGATT
TCTCCTGGCGTCTCGCTGGTATACGCCACCCTGCTGGGTATTGCTGGCTTTATGCTGCTGTGGTTTGGCGCTAATCCTTT
GGCCTGCTGGCTGGGGATGATGGGCTTCGTGGTCTACGTTGGCGTGTACAGCTTGTACATGAAGCGTCACTCCGTCTACG
GAACGCTGATTGGTTCTCTCTCCGGCGCAGCGCCGCCGGTGATTGGCTACTGCGCCGTAACGGGCGACTTTGACAGCGGC
GCGGCGATCCTGTTGGCTATTTTCAGCCTCTGGCAGATGCCGCACTCTTACGCCATCGCCATTTTCCGCTTTAAGGACTA
TCAGGCGGCCAATATCCCGGTTCTGCCGGTGGTAAAAGGAATCTCAGTCGCTAAAAACCACATCACGCTGTACATCATTG
CGTTTGCCGTTGCAACGCTAATGCTAACGTTGGGCGGTTATGCCGGTTACAAATACCTGGTGGTCGCCGCGGCGGTCAGC
GTTTGGTGGCTCGGCATGGCGCTACGCGGTTACAAAGTGGAAGATGATAAGGTCTGGGCGCGCAAGCTGTTCGGCTTCTC
TATCATTGCGATTACCGCGCTGAGTATCATGATGTCCGTTGATTTTATGGTGCCGAATTCGCAGAATCTGCTGACTTACG
TCTGGTAA

Upstream 100 bases:

>100_bases
TCTTTACCGTGCTGATCATCGCCATCCTGGTTGTGGGCTCCATCTGGATTATGTGGAACCTCAACTACAACATGATGATG
CACTAAGAGCGGCGAGTATG

Downstream 100 bases:

>100_bases
GTTCATCGTCACCTCTTCTATGCCGGATGGCGGCTTATGCCTTATCCGGCCTACAAAAGCACGTTACCTGTAGGCCGGAT
AAGCGACGTGAGTATCGCCA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLI
SPGVSLVYATLLGIAGFMLLWFGANPLACWLGMMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSG
AAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLTLGGYAGYKYLVVAAAVS
VWWLGMALRGYKVEDDKVWARKLFGFSIIAITALSIMMSVDFMVPNSQNLLTYVW

Sequences:

>Translated_295_residues
MFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLI
SPGVSLVYATLLGIAGFMLLWFGANPLACWLGMMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSG
AAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLTLGGYAGYKYLVVAAAVS
VWWLGMALRGYKVEDDKVWARKLFGFSIIAITALSIMMSVDFMVPNSQNLLTYVW
>Mature_295_residues
MFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLI
SPGVSLVYATLLGIAGFMLLWFGANPLACWLGMMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSG
AAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLTLGGYAGYKYLVVAAAVS
VWWLGMALRGYKVEDDKVWARKLFGFSIIAITALSIMMSVDFMVPNSQNLLTYVW

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=168, Percent_Identity=38.0952380952381, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786631, Length=295, Percent_Identity=95.5932203389831, Blast_Score=568, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71998235, Length=252, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325085, Length=190, Percent_Identity=30.5263157894737, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921064, Length=276, Percent_Identity=28.9855072463768, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32291; Mature: 32291

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00943 UBIA ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYID
CCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
RDIDRKMERTKNRVLVKGLISPGVSLVYATLLGIAGFMLLWFGANPLACWLGMMGFVVYV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSGAAILLAIFSLWQMPHSYAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHEEE
IFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLTLGGYAGYKYLVVAAAVS
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VWWLGMALRGYKVEDDKVWARKLFGFSIIAITALSIMMSVDFMVPNSQNLLTYVW
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEC
>Mature Secondary Structure
MFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYID
CCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
RDIDRKMERTKNRVLVKGLISPGVSLVYATLLGIAGFMLLWFGANPLACWLGMMGFVVYV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSGAAILLAIFSLWQMPHSYAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHEEE
IFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLTLGGYAGYKYLVVAAAVS
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VWWLGMALRGYKVEDDKVWARKLFGFSIIAITALSIMMSVDFMVPNSQNLLTYVW
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA