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The map label for this gene is mutY [H]

Identifier: 194737851

GI number: 194737851

Start: 3168679

End: 3169731

Strand: Direct

Name: mutY [H]

Synonym: SeSA_A3284

Alternate gene names: 194737851

Gene position: 3168679-3169731 (Clockwise)

Preceding gene: 194737657

Following gene: 194734289

Centisome position: 67.29

GC content: 54.89

Gene sequence:

>1053_bases
ATGCAAGCGTCTCAATTTTCAGCCCAGGTTCTGGACTGGTACGACAAATACGGGCGGAAAACGCTGCCCTGGCAAATTAA
CAAGACGCCTTACAAAGTATGGCTCTCGGAAGTCATGTTGCAACAAACGCAGGTGACGACGGTGATTCCTTACTTTGAGC
GATTTATGGCGCGCTTTCCCACGGTGACGGATTTAGCGAATGCGCCGCTGGATGAAGTGCTCCATTTATGGACCGGGCTC
GGCTATTACGCCCGCGCGCGTAATTTGCATAAAGCGGCGCAACAGGTGGCGACGCTTCACGGTGGAGAATTCCCGCAAAC
TTTTGCCGAAATCGCCGCGCTACCCGGCGTCGGGCGTTCAACCGCCGGCGCGATTCTCTCCCTCGCGTTAGGTAAACATT
ATCCGATTCTTGATGGAAACGTTAAACGTGTGCTGGCTCGCTGTTATGCTGTTAGCGGCTGGCCTGGAAAAAAAGAGGTG
GAGAATACGCTGTGGACGTTGAGCGAGCAAGTGACGCCCGCACGCGGCGTGGAGCGTTTTAATCAGGCGATGATGGATCT
GGGCGCGATGGTTTGTACGCGTTCAAAGCCAAAGTGCACCCTGTGTCCGCTGCAAAACGGTTGTATCGCCGCTGCGCATG
AAAGCTGGTCACGCTATCCGGGCAAGAAACCGAAACAGACGTTACCGGAGCGGACGGGTTACTTTTTATTGTTACAGCAT
AATCAGGAGATTTTCCTGGCGCAGCGCCCTCCCAGCGGTTTATGGGGCGGACTCTACTGCTTCCCGCAGTTCGCCAGCGA
AGATGAATTACGTGAATGGCTGGCGCAACGGCATGTTAACGCTGATAATTTGACCCAGCTTAACGCGTTTCGCCACACAT
TTAGCCATTTCCACCTGGATATTGTGCCTATGTGGCTTCCCGTGTCGTCACTGGACGCCTGCATGGATGAAGGCAGCGCG
CTCTGGTATAACTTAGCGCAACCGCCGTCAGTCGGACTGGCGGCCCCCGTGGAGCGCTTGTTACAGCAGTTACGTACCGG
AGCGCCAGTTTAA

Upstream 100 bases:

>100_bases
TTGCCGGATGCAAGCATGAAGCGCACTGCGGAAAGTTCCGGTTTACACCCTGCGGCCTCTGTGCTGCAATCTTGCCCCCG
GCAATAATGAATGAGTTTCC

Downstream 100 bases:

>100_bases
CGCCCCGGTCGATGAAGAGGATGACTTATGAGCAGAACGATTTTTTGTACTTACCTGCAACGCGACGCTGAAGGGCAAGA
TTTTCAGCTCTACCCTGGCG

Product: adenine DNA glycosylase

Products: Adenine [C]

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MQASQFSAQVLDWYDKYGRKTLPWQINKTPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVTDLANAPLDEVLHLWTGL
GYYARARNLHKAAQQVATLHGGEFPQTFAEIAALPGVGRSTAGAILSLALGKHYPILDGNVKRVLARCYAVSGWPGKKEV
ENTLWTLSEQVTPARGVERFNQAMMDLGAMVCTRSKPKCTLCPLQNGCIAAAHESWSRYPGKKPKQTLPERTGYFLLLQH
NQEIFLAQRPPSGLWGGLYCFPQFASEDELREWLAQRHVNADNLTQLNAFRHTFSHFHLDIVPMWLPVSSLDACMDEGSA
LWYNLAQPPSVGLAAPVERLLQQLRTGAPV

Sequences:

>Translated_350_residues
MQASQFSAQVLDWYDKYGRKTLPWQINKTPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVTDLANAPLDEVLHLWTGL
GYYARARNLHKAAQQVATLHGGEFPQTFAEIAALPGVGRSTAGAILSLALGKHYPILDGNVKRVLARCYAVSGWPGKKEV
ENTLWTLSEQVTPARGVERFNQAMMDLGAMVCTRSKPKCTLCPLQNGCIAAAHESWSRYPGKKPKQTLPERTGYFLLLQH
NQEIFLAQRPPSGLWGGLYCFPQFASEDELREWLAQRHVNADNLTQLNAFRHTFSHFHLDIVPMWLPVSSLDACMDEGSA
LWYNLAQPPSVGLAAPVERLLQQLRTGAPV
>Mature_350_residues
MQASQFSAQVLDWYDKYGRKTLPWQINKTPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVTDLANAPLDEVLHLWTGL
GYYARARNLHKAAQQVATLHGGEFPQTFAEIAALPGVGRSTAGAILSLALGKHYPILDGNVKRVLARCYAVSGWPGKKEV
ENTLWTLSEQVTPARGVERFNQAMMDLGAMVCTRSKPKCTLCPLQNGCIAAAHESWSRYPGKKPKQTLPERTGYFLLLQH
NQEIFLAQRPPSGLWGGLYCFPQFASEDELREWLAQRHVNADNLTQLNAFRHTFSHFHLDIVPMWLPVSSLDACMDEGSA
LWYNLAQPPSVGLAAPVERLLQQLRTGAPV

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=364, Percent_Identity=36.5384615384615, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI6912520, Length=364, Percent_Identity=36.5384615384615, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI115298654, Length=364, Percent_Identity=36.5384615384615, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI115298652, Length=364, Percent_Identity=36.5384615384615, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI115298650, Length=364, Percent_Identity=36.5384615384615, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI190358497, Length=364, Percent_Identity=36.5384615384615, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1789331, Length=350, Percent_Identity=90.5714285714286, Blast_Score=673, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.- [C]

Molecular weight: Translated: 39341; Mature: 39341

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQASQFSAQVLDWYDKYGRKTLPWQINKTPYKVWLSEVMLQQTQVTTVIPYFERFMARFP
CCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TVTDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGEFPQTFAEIAALPGVGRS
CHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCH
TAGAILSLALGKHYPILDGNVKRVLARCYAVSGWPGKKEVENTLWTLSEQVTPARGVERF
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
NQAMMDLGAMVCTRSKPKCTLCPLQNGCIAAAHESWSRYPGKKPKQTLPERTGYFLLLQH
HHHHHHHHHHHHCCCCCCEEECCCCCCCEEHHHHHHHHCCCCCCHHHCCCCCCEEEEEEC
NQEIFLAQRPPSGLWGGLYCFPQFASEDELREWLAQRHVNADNLTQLNAFRHTFSHFHLD
CCEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCEE
IVPMWLPVSSLDACMDEGSALWYNLAQPPSVGLAAPVERLLQQLRTGAPV
EEEHHCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQASQFSAQVLDWYDKYGRKTLPWQINKTPYKVWLSEVMLQQTQVTTVIPYFERFMARFP
CCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TVTDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGEFPQTFAEIAALPGVGRS
CHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCH
TAGAILSLALGKHYPILDGNVKRVLARCYAVSGWPGKKEVENTLWTLSEQVTPARGVERF
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
NQAMMDLGAMVCTRSKPKCTLCPLQNGCIAAAHESWSRYPGKKPKQTLPERTGYFLLLQH
HHHHHHHHHHHHCCCCCCEEECCCCCCCEEHHHHHHHHCCCCCCHHHCCCCCCEEEEEEC
NQEIFLAQRPPSGLWGGLYCFPQFASEDELREWLAQRHVNADNLTQLNAFRHTFSHFHLD
CCEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCEE
IVPMWLPVSSLDACMDEGSALWYNLAQPPSVGLAAPVERLLQQLRTGAPV
EEEHHCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Guanine-adenine mispair [C]

Specific reaction: Catalyzes the excision of adenine from a guanine-adenine mispair [C]

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]