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The map label for this gene is dmsA [H]

Identifier: 194737767

GI number: 194737767

Start: 4442478

End: 4444907

Strand: Direct

Name: dmsA [H]

Synonym: SeSA_A4560

Alternate gene names: 194737767

Gene position: 4442478-4444907 (Clockwise)

Preceding gene: 194734070

Following gene: 194736806

Centisome position: 94.34

GC content: 55.72

Gene sequence:

>2430_bases
ATGGAAATAAAAAAATGGCTGAACACAACCATAACCCGACGTGATGCTATTGTCGCTACTGCAAAAGTAGGGGCGGCGGT
GACGCTAAGTCAGGCGATTACGCTGCCTTTTGCTACCACTGCCCAGGCGCAGGATACCCCGATACCGAAGGATGCCAACG
ACGAAACCGTCAGGCACAGCGCCTGTCTGGTCAACTGTGGCAGCCGATGCCCGCTTAAGGTTATCGTGAAAAATGATCGC
ATCGTGCGCATTGAGCCGGAAGACGCGAAAGATGACGCGGTATTCGGCGAGCATCAGATTCGTCCCTGCCTGCGTGGGCG
TTCCAGTCGCTGGCGCGTCTATAGCCCGGATCGCATTAAGTATCCGATGAAAAGAGTGGGAAAACGCGGTGAAGGAAAAT
TTAAACGTATTTCATGGGATGAGGCCACGGCCTTTATTGCAGCGGAATTAACGCGCGTTAGCGAACAATATGGCCGGGAA
GCTATTTATTATAATTATCAATCCGGGGCATATTATCATACGCAGGGCAGGCCCGCCTGGATAAGATTATTAAATCTCAC
CGGCGGTTATTTAAATTATCACAACACCTATTCCACGGCGCAAATCGCCACCGCCACGCCCTATACCCACGGCGATTATG
TCGGTAGCCATTTTACGCAGATCGCGCATTCCGATCTGGTGGTGCTATTTGGTCTGAATCTCTCAGAAACGCGGATGTCC
GGCGGCGGTCAGGTTGAAGAGCTGCGCCGGGCGCTGGAGACCTCGAAAGCCCGAGTCATTATTATCGATCCGCGCTATAC
CGATTCGGTGATTACCGAACACGCCGAATGGCTACCGATTCGCCCAACCACGGACGCTGCGTTAGTCGCCGGCATCGCGC
ATACGCTGATTACCGAACAGCTTCTCGACGAGGCGCTGGTAAACCGCTATTGCGTCGGCTATGACCGTAGCACTTTGCCG
GACACGGCTGCGCCTAACGCCAGCTATAAAGATTATGTTCTTGGCACGGGCGATGACGGTATCGCGAAAACCCCGGAATG
GGCGGCGGATATCACCGGTATTCCGGCAACGCGTATTCGCCAACTGGCGCGCGAAATCGCCTCGGCGCGCGCCTGCTATA
TTTGCCAGGGCTGGGGGCCGCAGCGTCATGCCAACGGCGAACAAACCGTGCGTGCTATTCAGACGCTGCCAGCGTTAACC
GGCCACTTCGGGCGGCCCGGCACCAACAATGGCAACTGGCCTTACGGTACGCCGTATGGCGTGCCATTGTTGCCTGTCGG
TAAGAATCCGATCAAAACCTCTATTCCTTGCTATCTATGGACGGACGCCATTCAGCATCCGGAGAAAATGACCGCGACGA
CAATGGGCGTGAAAGGCGCGGACAGGCTAAAAACCGGGATTAAGCTGTTTTTCAACCAGGCCGGTAATACCTTGCTGAAT
CAGCACGGCGAAACGAACCGCACCCGTCAAATTCTCGCGGATGAATCGCTGTGTGAAACCATTATCGTGATTGAAAACCA
TATGACGCCCAGCGCGATGTATGCGGATCTGCTGTTGCCGGAGACCAGCTATCTTGAGGCGGAAGACCTGGTGGACAGCT
CCTATGCGGCGGGATCGCATAACTATATGATTGCGATTCAGAAAACCGTTAAACCGATGTGGGAAGTGCGCAGCACGTAT
GACATCTGCGCGGATATCGCCGGGCATCTTGGACTGCGCGAGCAATATACCGAGGGCCGAACTCAGGCGCAGTGGGCGGA
GATGCACTATCAGCAGATCCGTGAGAAACGTCCATACCTGCCGGAGTGGAGCGTGGCGAAAGAGATGGGCGTGATTGACC
AGCGTATCGCGACCGAGCAGCAGAGCCTTGCGTTTGCCGATTTCCGCGCCGACGCCGAGGCTAACCCACTCTCCACGCCG
TCGGGCAAAATTGAAATTTACTCCCAGGCGCTGGCGGATCTGGCGCAAACGTGGACTTTGCCAGAAGGCGAGCGAATTCC
CGCATTGCCGGAATTTTGTCCGGCGAAAGAGTCGCATCTTAACAAAGCGCTGACGGCGAAGTATCCGTTGCAGTTAAGCG
GCTTCCATACCAAAGGGCATACCCACTCGACCTACAGCAATGTGCTGATGCTACATGAGGCGGTGCCGGATGAAGTCTGG
ATTAACCCGATTGACGCCAGCGCCCGCCAATTGAAGTCCGGCGATCGGGTGCATGTATTCAATGACCGCGGCGTGGTGGA
GCTTCCCTGTAAAGTGACCCAGCGCATTTTACCCGGCGTGGCGGCGATGCCGCAGGGCGCGTGGACGCAGCTTGACGGCA
ACGGCGTTGATGTCGGCGGCTGTATCAATACGCTGACCAGCCACCATCCTTCGCCGCTGGCGAAAGGCAATCCGCAGCAT
ACCAATCTGGTTGAAATTAAACGCGCTTAA

Upstream 100 bases:

>100_bases
TGCGTTTGATCACAATCAATCAGCGCTAATGTTTAATCTATTATGATTAGTTTTCATTACATATTATTAATAATTATGGA
AGCAATGTGAGAAATAAAAA

Downstream 100 bases:

>100_bases
GGAGTGATGTACGATGAAACAGTATGGCTTTTATGTTGACTCCTCGCGCTGTTCAGGCTGTAAAACCTGCCAGGTAAGCT
GCAAGGATAATAAAGATCTG

Product: anaerobic dimethyl sulfoxide reductase chain a

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 809; Mature: 809

Protein sequence:

>809_residues
MEIKKWLNTTITRRDAIVATAKVGAAVTLSQAITLPFATTAQAQDTPIPKDANDETVRHSACLVNCGSRCPLKVIVKNDR
IVRIEPEDAKDDAVFGEHQIRPCLRGRSSRWRVYSPDRIKYPMKRVGKRGEGKFKRISWDEATAFIAAELTRVSEQYGRE
AIYYNYQSGAYYHTQGRPAWIRLLNLTGGYLNYHNTYSTAQIATATPYTHGDYVGSHFTQIAHSDLVVLFGLNLSETRMS
GGGQVEELRRALETSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITEQLLDEALVNRYCVGYDRSTLP
DTAAPNASYKDYVLGTGDDGIAKTPEWAADITGIPATRIRQLAREIASARACYICQGWGPQRHANGEQTVRAIQTLPALT
GHFGRPGTNNGNWPYGTPYGVPLLPVGKNPIKTSIPCYLWTDAIQHPEKMTATTMGVKGADRLKTGIKLFFNQAGNTLLN
QHGETNRTRQILADESLCETIIVIENHMTPSAMYADLLLPETSYLEAEDLVDSSYAAGSHNYMIAIQKTVKPMWEVRSTY
DICADIAGHLGLREQYTEGRTQAQWAEMHYQQIREKRPYLPEWSVAKEMGVIDQRIATEQQSLAFADFRADAEANPLSTP
SGKIEIYSQALADLAQTWTLPEGERIPALPEFCPAKESHLNKALTAKYPLQLSGFHTKGHTHSTYSNVLMLHEAVPDEVW
INPIDASARQLKSGDRVHVFNDRGVVELPCKVTQRILPGVAAMPQGAWTQLDGNGVDVGGCINTLTSHHPSPLAKGNPQH
TNLVEIKRA

Sequences:

>Translated_809_residues
MEIKKWLNTTITRRDAIVATAKVGAAVTLSQAITLPFATTAQAQDTPIPKDANDETVRHSACLVNCGSRCPLKVIVKNDR
IVRIEPEDAKDDAVFGEHQIRPCLRGRSSRWRVYSPDRIKYPMKRVGKRGEGKFKRISWDEATAFIAAELTRVSEQYGRE
AIYYNYQSGAYYHTQGRPAWIRLLNLTGGYLNYHNTYSTAQIATATPYTHGDYVGSHFTQIAHSDLVVLFGLNLSETRMS
GGGQVEELRRALETSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITEQLLDEALVNRYCVGYDRSTLP
DTAAPNASYKDYVLGTGDDGIAKTPEWAADITGIPATRIRQLAREIASARACYICQGWGPQRHANGEQTVRAIQTLPALT
GHFGRPGTNNGNWPYGTPYGVPLLPVGKNPIKTSIPCYLWTDAIQHPEKMTATTMGVKGADRLKTGIKLFFNQAGNTLLN
QHGETNRTRQILADESLCETIIVIENHMTPSAMYADLLLPETSYLEAEDLVDSSYAAGSHNYMIAIQKTVKPMWEVRSTY
DICADIAGHLGLREQYTEGRTQAQWAEMHYQQIREKRPYLPEWSVAKEMGVIDQRIATEQQSLAFADFRADAEANPLSTP
SGKIEIYSQALADLAQTWTLPEGERIPALPEFCPAKESHLNKALTAKYPLQLSGFHTKGHTHSTYSNVLMLHEAVPDEVW
INPIDASARQLKSGDRVHVFNDRGVVELPCKVTQRILPGVAAMPQGAWTQLDGNGVDVGGCINTLTSHHPSPLAKGNPQH
TNLVEIKRA
>Mature_809_residues
MEIKKWLNTTITRRDAIVATAKVGAAVTLSQAITLPFATTAQAQDTPIPKDANDETVRHSACLVNCGSRCPLKVIVKNDR
IVRIEPEDAKDDAVFGEHQIRPCLRGRSSRWRVYSPDRIKYPMKRVGKRGEGKFKRISWDEATAFIAAELTRVSEQYGRE
AIYYNYQSGAYYHTQGRPAWIRLLNLTGGYLNYHNTYSTAQIATATPYTHGDYVGSHFTQIAHSDLVVLFGLNLSETRMS
GGGQVEELRRALETSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITEQLLDEALVNRYCVGYDRSTLP
DTAAPNASYKDYVLGTGDDGIAKTPEWAADITGIPATRIRQLAREIASARACYICQGWGPQRHANGEQTVRAIQTLPALT
GHFGRPGTNNGNWPYGTPYGVPLLPVGKNPIKTSIPCYLWTDAIQHPEKMTATTMGVKGADRLKTGIKLFFNQAGNTLLN
QHGETNRTRQILADESLCETIIVIENHMTPSAMYADLLLPETSYLEAEDLVDSSYAAGSHNYMIAIQKTVKPMWEVRSTY
DICADIAGHLGLREQYTEGRTQAQWAEMHYQQIREKRPYLPEWSVAKEMGVIDQRIATEQQSLAFADFRADAEANPLSTP
SGKIEIYSQALADLAQTWTLPEGERIPALPEFCPAKESHLNKALTAKYPLQLSGFHTKGHTHSTYSNVLMLHEAVPDEVW
INPIDASARQLKSGDRVHVFNDRGVVELPCKVTQRILPGVAAMPQGAWTQLDGNGVDVGGCINTLTSHHPSPLAKGNPQH
TNLVEIKRA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=813, Percent_Identity=50.5535055350554, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=807, Percent_Identity=51.177199504337, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=807, Percent_Identity=48.5749690210657, Blast_Score=751, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=756, Percent_Identity=30.026455026455, Blast_Score=261, Evalue=9e-71,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=30.4862023653088, Blast_Score=247, Evalue=2e-66,
Organism=Escherichia coli, GI87081994, Length=853, Percent_Identity=28.253223915592, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI3868721, Length=769, Percent_Identity=25.4876462938882, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 89662; Mature: 89662

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKKWLNTTITRRDAIVATAKVGAAVTLSQAITLPFATTAQAQDTPIPKDANDETVRHS
CCHHHHHHHHHHCCCCEEEEECCCCEEEEHHHEECCEECCCCCCCCCCCCCCCCHHHHHH
ACLVNCGSRCPLKVIVKNDRIVRIEPEDAKDDAVFGEHQIRPCLRGRSSRWRVYSPDRIK
HHEEECCCCCCEEEEEECCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCC
YPMKRVGKRGEGKFKRISWDEATAFIAAELTRVSEQYGREAIYYNYQSGAYYHTQGRPAW
CCHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCEE
IRLLNLTGGYLNYHNTYSTAQIATATPYTHGDYVGSHFTQIAHSDLVVLFGLNLSETRMS
EEEEECCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHCC
GGGQVEELRRALETSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITEQ
CCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHH
LLDEALVNRYCVGYDRSTLPDTAAPNASYKDYVLGTGDDGIAKTPEWAADITGIPATRIR
HHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHCCCCCCHHHHH
QLAREIASARACYICQGWGPQRHANGEQTVRAIQTLPALTGHFGRPGTNNGNWPYGTPYG
HHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
VPLLPVGKNPIKTSIPCYLWTDAIQHPEKMTATTMGVKGADRLKTGIKLFFNQAGNTLLN
CEEEECCCCCCCCCCCEEEEHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHH
QHGETNRTRQILADESLCETIIVIENHMTPSAMYADLLLPETSYLEAEDLVDSSYAAGSH
CCCCCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCC
NYMIAIQKTVKPMWEVRSTYDICADIAGHLGLREQYTEGRTQAQWAEMHYQQIREKRPYL
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCC
PEWSVAKEMGVIDQRIATEQQSLAFADFRADAEANPLSTPSGKIEIYSQALADLAQTWTL
CCHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCC
PEGERIPALPEFCPAKESHLNKALTAKYPLQLSGFHTKGHTHSTYSNVLMLHEAVPDEVW
CCCCCCCCCCCCCCCCHHHHHHHHEECCCEEEECEECCCCCCCHHHHEEEEECCCCCCCE
INPIDASARQLKSGDRVHVFNDRGVVELPCKVTQRILPGVAAMPQGAWTQLDGNGVDVGG
ECCCCHHHHHHCCCCEEEEECCCCEEEECHHHHHHHCCCHHCCCCCCCEEECCCCCCHHH
CINTLTSHHPSPLAKGNPQHTNLVEIKRA
HHHHHHCCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MEIKKWLNTTITRRDAIVATAKVGAAVTLSQAITLPFATTAQAQDTPIPKDANDETVRHS
CCHHHHHHHHHHCCCCEEEEECCCCEEEEHHHEECCEECCCCCCCCCCCCCCCCHHHHHH
ACLVNCGSRCPLKVIVKNDRIVRIEPEDAKDDAVFGEHQIRPCLRGRSSRWRVYSPDRIK
HHEEECCCCCCEEEEEECCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCC
YPMKRVGKRGEGKFKRISWDEATAFIAAELTRVSEQYGREAIYYNYQSGAYYHTQGRPAW
CCHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCEE
IRLLNLTGGYLNYHNTYSTAQIATATPYTHGDYVGSHFTQIAHSDLVVLFGLNLSETRMS
EEEEECCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHCC
GGGQVEELRRALETSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITEQ
CCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHH
LLDEALVNRYCVGYDRSTLPDTAAPNASYKDYVLGTGDDGIAKTPEWAADITGIPATRIR
HHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHCCCCCCHHHHH
QLAREIASARACYICQGWGPQRHANGEQTVRAIQTLPALTGHFGRPGTNNGNWPYGTPYG
HHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
VPLLPVGKNPIKTSIPCYLWTDAIQHPEKMTATTMGVKGADRLKTGIKLFFNQAGNTLLN
CEEEECCCCCCCCCCCEEEEHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHH
QHGETNRTRQILADESLCETIIVIENHMTPSAMYADLLLPETSYLEAEDLVDSSYAAGSH
CCCCCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCC
NYMIAIQKTVKPMWEVRSTYDICADIAGHLGLREQYTEGRTQAQWAEMHYQQIREKRPYL
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCC
PEWSVAKEMGVIDQRIATEQQSLAFADFRADAEANPLSTPSGKIEIYSQALADLAQTWTL
CCHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCC
PEGERIPALPEFCPAKESHLNKALTAKYPLQLSGFHTKGHTHSTYSNVLMLHEAVPDEVW
CCCCCCCCCCCCCCCCHHHHHHHHEECCCEEEECEECCCCCCCHHHHEEEEECCCCCCCE
INPIDASARQLKSGDRVHVFNDRGVVELPCKVTQRILPGVAAMPQGAWTQLDGNGVDVGG
ECCCCHHHHHHCCCCEEEEECCCCEEEECHHHHHHHCCCHHCCCCCCCEEECCCCCCHHH
CINTLTSHHPSPLAKGNPQHTNLVEIKRA
HHHHHHCCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]