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The map label for this gene is emrA [H]

Identifier: 194737453

GI number: 194737453

Start: 2869105

End: 2870277

Strand: Direct

Name: emrA [H]

Synonym: SeSA_A2962

Alternate gene names: 194737453

Gene position: 2869105-2870277 (Clockwise)

Preceding gene: 194734187

Following gene: 194738054

Centisome position: 60.93

GC content: 54.39

Gene sequence:

>1173_bases
ATGAGCGCAAATGCGGAGATCCAAACCCCGCAGCAACCGGCTAAGAAGAAAGGCAAACGCAAAACAGCGCTGCTACTTCT
TACCTTGCTCTTTGTTATTATTGCCGTGGCATATGGAATTTATTGGTTTTTAGTATTGCGTCATATTGAAGAGACAGATG
ATGCTTACGTGGCAGGGAACCAGGTTCAAATCATGGCGCAGGTGTCAGGCAGCGTGACGAAAGTCTGGGCTGATAACACC
GACTTTGTAAAAGAGGGCGATGTTCTGGTCACGCTCGATCAGACTGACGCCAAACAAGCGTTTGAAAAAGCTAAAACGGC
GCTGGCCTCCAGCGTGCGTCAGACGCACCAGTTGATGATTAACAGCAAGCAGTTGCAGGCGAATATCGACGTGCAAAAAA
CCGCCCTGGCGCAAGCGCAAAGCGACCTTAACCGTCGTGTGCCGCTGGGTAACGCCAATCTTATTGGCCGTGAAGAGTTG
CAACACGCCCGCGATGCCGTCGCCAGCGCGCAGGCACAGCTGGATGTTGCCATTCAACAGTACAATGCCAACCAGGCAAT
GATACTCAACAGTAAACTGGAAGATCAGCCCGCGGTTCAACAAGCGGCGACCGAAGTGCGTAACGCCTGGCTGGCGCTGG
AGCGTACCCGCATCGTCAGCCCAATGACCGGTTATGTCTCCCGCCGCGCCGTCCAGCCTGGCGCGCAAATCAGCCCCACC
ACGCCGCTGATGGCCGTGGTGCCTGCAACCGATCTGTGGGTGGACGCTAACTTTAAAGAGACTCAATTAGCGAATATGCG
CATTGGGCAGCCAGTGACGGTGATTACTGATATTTATGGCGACGACGTAAAATACACCGGTAAAGTCGTCGGTCTGGATA
TGGGAACAGGCAGCGCCTTCTCCCTGCTGCCCGCGCAAAATGCGACGGGTAACTGGATTAAAGTGGTTCAACGTCTGCCG
GTACGCGTCGAACTGGACGCCCGCCAGTTAGAACAACATCCGCTGCGTATTGGTTTATCGACGCTGGTCACCGTGGATAC
CGCTAATCGCGACGGTCAGGTACTGGCCAGCCAGGTACGAACGACGCCGGTTGCCGAAAGTAACGCACGCGAAATTAATC
TCGCGCCGGTCAATAAACTGATCGACGACATCGTACAGGCTAACGCGGGTTAA

Upstream 100 bases:

>100_bases
TTAATAACAGGAAAGCGGACAGGCCGGCACGCGTTACTGCTGGCCTTTCTGACAACAGGTCGGCTCAGCCGATGTGAATA
ATAAGATCGTGGAGAACAAC

Downstream 100 bases:

>100_bases
TCCTGAGGTGCGTGTGATGCAACAGCAAAAACCGCTGGAAGGCGCGCAGCTCGTCATCATGACGATCGCGCTGTCGCTGG
CGACATTCATGCAGGTGCTG

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSANAEIQTPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGNQVQIMAQVSGSVTKVWADNT
DFVKEGDVLVTLDQTDAKQAFEKAKTALASSVRQTHQLMINSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREEL
QHARDAVASAQAQLDVAIQQYNANQAMILNSKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT
TPLMAVVPATDLWVDANFKETQLANMRIGQPVTVITDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVRTTPVAESNAREINLAPVNKLIDDIVQANAG

Sequences:

>Translated_390_residues
MSANAEIQTPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGNQVQIMAQVSGSVTKVWADNT
DFVKEGDVLVTLDQTDAKQAFEKAKTALASSVRQTHQLMINSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREEL
QHARDAVASAQAQLDVAIQQYNANQAMILNSKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT
TPLMAVVPATDLWVDANFKETQLANMRIGQPVTVITDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVRTTPVAESNAREINLAPVNKLIDDIVQANAG
>Mature_389_residues
SANAEIQTPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGNQVQIMAQVSGSVTKVWADNTD
FVKEGDVLVTLDQTDAKQAFEKAKTALASSVRQTHQLMINSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREELQ
HARDAVASAQAQLDVAIQQYNANQAMILNSKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPTT
PLMAVVPATDLWVDANFKETQLANMRIGQPVTVITDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPV
RVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVRTTPVAESNAREINLAPVNKLIDDIVQANAG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=390, Percent_Identity=90, Blast_Score=708, Evalue=0.0,
Organism=Escherichia coli, GI1788711, Length=378, Percent_Identity=50, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1790519, Length=310, Percent_Identity=27.4193548387097, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI87081951, Length=313, Percent_Identity=27.1565495207668, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789637, Length=330, Percent_Identity=25.1515151515152, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42516; Mature: 42385

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANAEIQTPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGN
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
QVQIMAQVSGSVTKVWADNTDFVKEGDVLVTLDQTDAKQAFEKAKTALASSVRQTHQLMI
EEEEEEECCCCEEEEECCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREELQHARDAVASAQAQLDVAIQQ
CCHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YNANQAMILNSKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
TPLMAVVPATDLWVDANFKETQLANMRIGQPVTVITDIYGDDVKYTGKVVGLDMGTGSAF
CCEEEEECCCEEEEECCCCHHHHCCCCCCCCEEEEEECCCCCEEECCEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHCCCHHEEEEEEEEEECCCCCCHHHHHHHH
TTPVAESNAREINLAPVNKLIDDIVQANAG
CCCCCCCCCCEEECHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SANAEIQTPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGN
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
QVQIMAQVSGSVTKVWADNTDFVKEGDVLVTLDQTDAKQAFEKAKTALASSVRQTHQLMI
EEEEEEECCCCEEEEECCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREELQHARDAVASAQAQLDVAIQQ
CCHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YNANQAMILNSKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
TPLMAVVPATDLWVDANFKETQLANMRIGQPVTVITDIYGDDVKYTGKVVGLDMGTGSAF
CCEEEEECCCEEEEECCCCHHHHCCCCCCCCEEEEEECCCCCEEECCEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHCCCHHEEEEEEEEEECCCCCCHHHHHHHH
TTPVAESNAREINLAPVNKLIDDIVQANAG
CCCCCCCCCCEEECHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]