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The map label for this gene is pipB [H]

Identifier: 194737406

GI number: 194737406

Start: 1135122

End: 1135997

Strand: Reverse

Name: pipB [H]

Synonym: SeSA_A1152

Alternate gene names: 194737406

Gene position: 1135997-1135122 (Counterclockwise)

Preceding gene: 194734183

Following gene: 194734148

Centisome position: 24.12

GC content: 39.5

Gene sequence:

>876_bases
ATGCCAATAACTAACGCGTCCCCAGAAAATATATTAAGATATTTGCATGCGGCCGGTACCGGTACGAAAGAAGCAATGAA
AAGTGCAACTTCACCACGCGGTATACTGGAATGGTTTGTCAATTTTTTTACCTGTGGTGGAGTAAGAAGAAGCAATGAAA
GATGCTTTCGGGAGGTAATTGGAAAACTGACCACATCATTATTATATGTAAATAAAGATGCTTTCTTCGATGGTAATAAA
ATATTTCTGGAGGATGTCAACGGGTGTACTATATGTCTGTCATGTGGAGCAGCATCCGAAAATACGGATCCCATGGTCAT
TATTGAAGTGAACAAAAATGGAAAAACTGTAACGGATAACGTTGATAGTGAGAGATTTTGGAATGTATGTCGAATGTTAA
AGCTGATGAGTAAACATAATATACAACAGCCTGATTCACTTATAACCGAGGATGGTTTTCTGAACCTGCGCGGAGTAAAC
CTGGCTCATAAAGATTTCCAGGGGGAAGATTTGTCAAAAATAGATGCTTCTAATGCAGATTTCCGTGAAACAACTCTTTC
TAATGTAAATTTAGTCGGTGCAAATTTGTGTTGTGCAAATCTACACGCTGTAAATCTAATGGGTTCAAACATGACTAAAG
CAAACCTGACTCACGCAGACCTGACTTGCGCTAACATGTCCGGTGTAAACTTAACCGCTGCAATTCTATTCGGCTCAGAC
TTAACTGACACCAAACTAAATGGTGCAAAATTAGATAAGATAGCTCTAACTTTAGCGAAAGCATTAACAGGAGCCGATCT
GACAGGTAGTCAACATACCCCTACTCCACTCCCGGATTACAATGATAAAACGCTTTTCCCCCATCCAATATTTTAG

Upstream 100 bases:

>100_bases
TACAAAAATCACCTTATATCTTTTTTTATTATTCCTTGTATAAATGTGACTTGACTCACACCTATAAGGAATCGACTCAC
TTCCATAAGAAGGAATCAAA

Downstream 100 bases:

>100_bases
TCGAGATAAAGGGATTTTATAAACAAGAAGTATTCAAACAGAAGCCCCCCTTGTTTTATTAAATAAACCCCGCCCCTAAG
TTTCATTATAAATAACATTT

Product: secreted effector protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERCFREVIGKLTTSLLYVNKDAFFDGNK
IFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDNVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVN
LAHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSD
LTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDKTLFPHPIF

Sequences:

>Translated_291_residues
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERCFREVIGKLTTSLLYVNKDAFFDGNK
IFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDNVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVN
LAHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSD
LTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDKTLFPHPIF
>Mature_290_residues
PITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERCFREVIGKLTTSLLYVNKDAFFDGNKI
FLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDNVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNL
AHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSDL
TDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDKTLFPHPIF

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Does not appear to be required for the formation or the maintenance of either Salmonella-containing vacuole (SCV) or the Salmonella-induced filaments

COG id: COG1357

COG function: function code S; Uncharacterized low-complexity proteins

Gene ontology:

Cell location: Secreted. Host membrane. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cell. Concentrates in detergent-resistant microdomains (DRMs) that are present on the membranes of Salmonella-containing vacuole (SCV) and Sal

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 pentapeptide repeat domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001646 [H]

Pfam domain/function: PF00805 Pentapeptide [H]

EC number: NA

Molecular weight: Translated: 31681; Mature: 31550

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERCFREVI
CCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GKLTTSLLYVNKDAFFDGNKIFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDN
HHHHHHEEEECCCCEECCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCCEEECC
VDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNLAHKDFQGEDLSKIDASNAD
CCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECCEECCCCCCCCHHHCCCCCCC
FRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSD
HHHHHHCCCEEEECCEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCCCEEEEEEECCC
LTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDKTLFPHPIF
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERCFREVI
CCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GKLTTSLLYVNKDAFFDGNKIFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDN
HHHHHHEEEECCCCEECCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCCEEECC
VDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNLAHKDFQGEDLSKIDASNAD
CCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECCEECCCCCCCCHHHCCCCCCC
FRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSD
HHHHHHCCCEEEECCEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCCCEEEEEEECCC
LTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDKTLFPHPIF
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677609; 12864852 [H]