| Definition | Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633 chromosome, complete genome. |
|---|---|
| Accession | NC_011094 |
| Length | 4,709,075 |
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The map label for this gene is menD [H]
Identifier: 194737329
GI number: 194737329
Start: 2421528
End: 2423198
Strand: Reverse
Name: menD [H]
Synonym: SeSA_A2537
Alternate gene names: 194737329
Gene position: 2423198-2421528 (Counterclockwise)
Preceding gene: 194737064
Following gene: 194737755
Centisome position: 51.46
GC content: 59.49
Gene sequence:
>1671_bases ATGTCAGTAAGTGCATTTAACCGGCGCTGGGCGGCGGTCATCCTGGAAGCCTTAACCCGTCATGGCGTCAGGCATGTTTG TATCGCCCCTGGTTCCCGTTCCACGCCGCTCACGTTGGCGGCGGCAGAGAATCCTGCTTTTATTCACCATACGCACTTTG ATGAGCGTGGGCTTGGTCATCTGGCGTTAGGGCTGGCGAAAGTCAGCCAACAGCCTGTTGCCGTTATTGTCACTTCAGGT ACCGCCGTGGCGAACCTCTATCCGGCCTTGATTGAGGCGGGGCTGACGGGCGAGAAGCTTATTTTACTTACCGCCGATCG CCCGCCGGAGCTGATTGACTGCGGCGCCAACCAGGCGATCCGTCAGGCGGGGATGTTTTCCTCGCACCCCTCCCAAACTC TGTCGTTGCCGCGTCCCACGCAGGATATTCCGGCGCGCTGGCTGGTGTCGACCATCGATAATGCGCTCGCCATGCTTCAT GCGGGCGCTCTGCACATTAACTGTCCTTTTGCCGAACCGCTGTATGGCGATATGAATGACACCGGCCTGGTCTGGCAGCA GCGTCTCGGCGACTGGTGGCAGGATGAAAAACCCTGGCTGCGCGAAGCGCGTCGACTGGCAAGCGACAAACAGCGCGACT GGTTCTTCTGGCGACAAAAACGCGGCGTCGTCGTCGCCGGGCGTATGAGCGCGGAAGAAGGCAAAAAAGTGGCGCAGTGG GCGCAAACTCTGGGATGGCCATTAATTGGCGACGTATTGTCGCAAACCGGGCAGCCGCTGCCGTGCGCCGACCTGTGGCT CGGCAACGCCAAAGCGGTGACCGAACTGCAGCAGGCGCAAATTGTCGTCCAGCTTGGCAGTAGCCTTACCGGAAAACGCT TACTGCAATGGCAGGCAACCTGCGAGCCGGAAGAGTATTGGGTAATCGACAATATTGAAGGTCGTCTGGACCCGGCGCAC CATCGTGGACGCAGACTGATAGCGAAAATCGCCGACTGGCTGGAGATGCATCCGGCGGAAAAACGTAAACCGTGGTGTGT AGAGATCCCGCGTCTGGCGGAACTGGCGTGGCAACGGGTGGTCGCGCAGCGAGACACCTTTGGCGAAGCACAGCTGGCGC ACCGTATCCGCGACTATCTGCCGGAGCAGGGGCAATTGTTCGTGGGCAATAGTCTGGTGGTGCGTCTGATCGACGCGCTG TCGCAGTTGCCGGCTGGCTATCCGGTATACAGCAATCGCGGGGCGAGCGGCATTGACGGCCTGCTTTCCACAGCGGCGGG CGTGCAGCGCGCCAGCGCCAAATCGACGCTGGCTATCGTCGGCGATTTATCCGCGCTGTACGATCTTAACGCGCTGGCGT TACTACGTCAGGTATCCGCGCCGTTTGTGTTGATTGTGGTCAACAATAACGGCGGGCAGATCTTTTCCCTGCTGCCGACG CCGCAAAGCAAACGTGAGCGCTTTTATTTGATGCCGCAAAACGTCCATTTTGACCATGCGGCCGCCATGTTTAACCTGCG CTATCATCGCCCGGAAAACTGGGAAGAACTGGAGTCTGCGCTGGCTGGCGCGTGGCGAACCCCGGCGACGACGGTGATTG AGCTGGTGGTAAACGATACGGACGGCGCGCAGACGTTGCAGCAACTTTTGGCTCAGGTAAGCCATCTATGA
Upstream 100 bases:
>100_bases CAGATGGATGTGTAATGAGTCACATATTCCCGACCCATATCAATAATCCATTTTTGCAGCTCTTTATACTTAGTCCCAAT GATTGATACCGGACAAACTC
Downstream 100 bases:
>100_bases TGTTGCACGCGCAGCACATGCCCGGACAGCCTGGGGCGCCCTCGCTGGTTTTCCTGCACGGTTTTTCTGGCGATTGCCGT GAATGGCAGCCGGTTGGCGA
Product: 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase
Products: NA
Alternate protein names: SEPHCHC synthase; Menaquinone biosynthesis protein menD [H]
Number of amino acids: Translated: 556; Mature: 555
Protein sequence:
>556_residues MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSG TAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFSSHPSQTLSLPRPTQDIPARWLVSTIDNALAMLH AGALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLASDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQW AQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAH HRGRRLIAKIADWLEMHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDAL SQLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPT PQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDTDGAQTLQQLLAQVSHL
Sequences:
>Translated_556_residues MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSG TAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFSSHPSQTLSLPRPTQDIPARWLVSTIDNALAMLH AGALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLASDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQW AQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAH HRGRRLIAKIADWLEMHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDAL SQLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPT PQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDTDGAQTLQQLLAQVSHL >Mature_555_residues SVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSGT AVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFSSHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHA GALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLASDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQWA QTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAHH RGRRLIAKIADWLEMHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALS QLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPTP QSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDTDGAQTLQQLLAQVSHL
Specific function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-ca
COG id: COG1165
COG function: function code H; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family. MenD subfamily [H]
Homologues:
Organism=Escherichia coli, GI1788599, Length=556, Percent_Identity=90.6474820143885, Blast_Score=1044, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004433 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.9 [H]
Molecular weight: Translated: 61514; Mature: 61383
Theoretical pI: Translated: 7.48; Mature: 7.48
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 1.3 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGH CCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCHH LALGLAKVSQQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAI HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCHHH RQAGMFSSHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHAGALHINCPFAEPLYGDMND HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC TGLVWQQRLGDWWQDEKPWLREARRLASDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQW CHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHEEECCCCEEEEECCCHHHHHHHHHH AQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQAT HHHHCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC CEPEEYWVIDNIEGRLDPAHHRGRRLIAKIADWLEMHPAEKRKPWCVEIPRLAELAWQRV CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHH VAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDG HHHCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH LLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPT HHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCC PQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDT CCCCCCEEEECCCCCCCHHHHHEEEEEECCCCCHHHHHHHHHCCCCCCHHEEEEEEEECC DGAQTLQQLLAQVSHL CHHHHHHHHHHHHHCC >Mature Secondary Structure SVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGH CCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCHH LALGLAKVSQQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAI HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCHHH RQAGMFSSHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHAGALHINCPFAEPLYGDMND HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC TGLVWQQRLGDWWQDEKPWLREARRLASDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQW CHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHEEECCCCEEEEECCCHHHHHHHHHH AQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQAT HHHHCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC CEPEEYWVIDNIEGRLDPAHHRGRRLIAKIADWLEMHPAEKRKPWCVEIPRLAELAWQRV CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHH VAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDG HHHCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH LLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPT HHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCC PQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDT CCCCCCEEEECCCCCCCHHHHHEEEEEECCCCCHHHHHHHHHCCCCCCHHEEEEEEEECC DGAQTLQQLLAQVSHL CHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA