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The map label for this gene is rnz [H]

Identifier: 194737306

GI number: 194737306

Start: 2425454

End: 2426479

Strand: Direct

Name: rnz [H]

Synonym: SeSA_A2542

Alternate gene names: 194737306

Gene position: 2425454-2426479 (Clockwise)

Preceding gene: 194734621

Following gene: 194734442

Centisome position: 51.51

GC content: 54.87

Gene sequence:

>1026_bases
TTGAGGAACGGTAAGTTCGCTATGGTGGAGATCCTGCCAGTCAATCATGATGCGCTCCTGTGTTGTGGTAATCTTGGGTT
AAACGATAACCAAACGTGTATGGACAAGATGGAATTAATTTTTTTAGGTACGTCCGCAGGCGTTCCCACGCGCTCACGCA
ATGTAACGGCAATTTTATTACATCTGCAACATCCAACGCAGCCGGGAGTATGGCTTTTTGATTGCGGCGAAGGGACACAG
CATCAAATGCTTAATACCGCGTTTCATCCCGGTAAGCTTGAGCGCATTTTTATCAGCCATCTTCACGGAGATCATCTGTT
TGGCCTGCCGGGTCTGCTATGCAGCCGGTCGATGGCGGGGAATCCCCATCCGCTAACCGTATACGGGCCTCAAGGCGTGC
GTGAGTTTATTGCAACCACACTGCGCCTTAGCGGTTCATGGACCGATTTTCCGTTGCAAATTGAAGAAATTAGCGCAGGC
GATATTCTTGACGACGGTCTGCGTAAAGTGACCGCGTTCAGGCTGGAGCATCCACTGGAGTGCTACGGATATCGCGTTGT
TGAACATGACAAGCCTGGCGCGCTGAATGCCAGGGCGTTAAAAGCCGCAGGCGTTACGCCCGGCCCGCTGTTTCAGGCGT
TGAAGGCAGGAAAAACCGTCACGCTTGCCGATGGAAGGCAGATCAATGGCGCCGACTACCTTGCTCCCGCCGTGGCCGGG
AAATCAGTGGCGATTTTCGGCGATACCGCGCCCTGCGAGGCCGCCCTCGCGCTGGCGCAAGGCGTGGATGTGATGGTACA
TGAAACCACGCTGGATGCGTCAATGGAGGAGAAAGCCAACGCTCGCGGACACAGCTCCACCCGTCAAACCGCGACGCTGG
CGCGGGAAGCTGACGTCGGTCGGCTGATCATGACCCATATTAGCTCACGCTATGACGATAAAGGCTGTCAGCGCTTACTG
GCGGAATGCCGCGCTATTTTCCCGGCGACGGAGCTGGCTTACGATTTTTCTGTTTTCCCGGTTTAG

Upstream 100 bases:

>100_bases
GCCGATTGTCGCCGACTAAATCATCGCCATCCACATCCAGGTAAGGACAGCGCTGTTCTACCACAAAGACCGCGCAGCGC
AATTTGAGTAACGCGTAAAG

Downstream 100 bases:

>100_bases
CGCTCCATTTTTTGTCCTCATTGCCGATAACACTAAAAAAGGCAGGCTTTCATAATGAGGTGAGGATGGACAATTTTCAG
AAAGATATTGATGACAGGGC

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRNGKFAMVEILPVNHDALLCCGNLGLNDNQTCMDKMELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQ
HQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSRSMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAG
DILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALNARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAG
KSVAIFGDTAPCEAALALAQGVDVMVHETTLDASMEEKANARGHSSTRQTATLAREADVGRLIMTHISSRYDDKGCQRLL
AECRAIFPATELAYDFSVFPV

Sequences:

>Translated_341_residues
MRNGKFAMVEILPVNHDALLCCGNLGLNDNQTCMDKMELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQ
HQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSRSMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAG
DILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALNARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAG
KSVAIFGDTAPCEAALALAQGVDVMVHETTLDASMEEKANARGHSSTRQTATLAREADVGRLIMTHISSRYDDKGCQRLL
AECRAIFPATELAYDFSVFPV
>Mature_341_residues
MRNGKFAMVEILPVNHDALLCCGNLGLNDNQTCMDKMELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQ
HQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSRSMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAG
DILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALNARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAG
KSVAIFGDTAPCEAALALAQGVDVMVHETTLDASMEEKANARGHSSTRQTATLAREADVGRLIMTHISSRYDDKGCQRLL
AECRAIFPATELAYDFSVFPV

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=361, Percent_Identity=33.5180055401662, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI260166619, Length=110, Percent_Identity=39.0909090909091, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI260166622, Length=110, Percent_Identity=39.0909090909091, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI145553959, Length=110, Percent_Identity=39.0909090909091, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082078, Length=305, Percent_Identity=80.9836065573771, Blast_Score=523, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471
- InterPro:   IPR013469 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 36883; Mature: 36883

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNGKFAMVEILPVNHDALLCCGNLGLNDNQTCMDKMELIFLGTSAGVPTRSRNVTAILL
CCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHCCEEEEEEECCCCCCCCCCCEEEEEE
HLQHPTQPGVWLFDCGEGTQHQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSRSMAG
EEECCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHEEHHCCCCCCCCCHHHHCCCCCC
NPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAGDILDDGLRKVTAFRLEHPLE
CCCEEEEECCHHHHHHHHHHHEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHH
CYGYRVVEHDKPGALNARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAG
HHCEEEEECCCCCCCCCHHEEECCCCCHHHHHHHHCCCEEEEECCCEECCCHHHHHHHCC
KSVAIFGDTAPCEAALALAQGVDVMVHETTLDASMEEKANARGHSSTRQTATLAREADVG
CEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCHH
RLIMTHISSRYDDKGCQRLLAECRAIFPATELAYDFSVFPV
HHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHEEEEEECCC
>Mature Secondary Structure
MRNGKFAMVEILPVNHDALLCCGNLGLNDNQTCMDKMELIFLGTSAGVPTRSRNVTAILL
CCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHCCEEEEEEECCCCCCCCCCCEEEEEE
HLQHPTQPGVWLFDCGEGTQHQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSRSMAG
EEECCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHEEHHCCCCCCCCCHHHHCCCCCC
NPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAGDILDDGLRKVTAFRLEHPLE
CCCEEEEECCHHHHHHHHHHHEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHH
CYGYRVVEHDKPGALNARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAG
HHCEEEEECCCCCCCCCHHEEECCCCCHHHHHHHHCCCEEEEECCCEECCCHHHHHHHCC
KSVAIFGDTAPCEAALALAQGVDVMVHETTLDASMEEKANARGHSSTRQTATLAREADVG
CEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCHH
RLIMTHISSRYDDKGCQRLLAECRAIFPATELAYDFSVFPV
HHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA