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The map label for this gene is yopJ [H]

Identifier: 194737304

GI number: 194737304

Start: 2917095

End: 2917961

Strand: Reverse

Name: yopJ [H]

Synonym: SeSA_A3018

Alternate gene names: 194737304

Gene position: 2917961-2917095 (Counterclockwise)

Preceding gene: 194737945

Following gene: 194738347

Centisome position: 61.96

GC content: 41.64

Gene sequence:

>867_bases
ATGCTAAGTCCTACGACTCGTAATATGGGGGCGAGTTTATCGCCTCAGTCTGACGTCAGCGGGGAGCTAAACACCGAAGC
ATTGACCTGTATTGTTGAGCGTCTGGAAAGTGAAATTATAGATGGCAGCTGGATTCATATCAGTTACGAGGAAACCGATC
TCGAAATGATGCCTTTTCTTGTTGCACAGGCCAATAAGAAGTATCCAGAGTTAAATCTTAAATTTGTTATGTCAGTCCAT
GAGCTTGTTTCCTCTATAAAGGAGACCAGAATGGAAGGCGTTGAATCTGCCCGATTTATCGTAAATATGGGAAGTTCAGG
TATCCATGTTTCAGTCGTCGATTTTAGAGTTATGGACGGAAAGACATCGGTGATTTTGTTCGAACCAGCAGCGTGTAGCG
CTTTTGGACCTGCTTTACTGGCATTGAGGACCAAAGCAGCTCTTGAACGTGAACAATTGCCTGATTGTTATTTTGCTATG
GTCGAGCTGGACATTCAACGAAGCTCTTCTGAATGCGGTATTTTTAGCCTGGCGCTCGCCAAAAAACTTCATCTTGAATT
TATGAACTTAGTAAAAATTCATGAAGATAATATTTGTGAACGTCTGTGTGGTGAAGAACCTTTTCTCCCGTCCGATAAAG
CAGACCGCTATCTGCCGGTGAGTTTTTACAAACATACTCAAGGCGTACAACGATTAAATGAATATGTGCAGGCCAATCCG
GCGGCGGGAAGCAGTATAGTAAACAAAAAGAATGAAACGCTTTATGAGCGATTCGATAACAATGCCGTTATGCTAAACGA
TAAAAAACTCTCTATATCCGCTCATAAAAAAAGGATAGCTGAATATAAGTCTTTACTTAAACCGTAA

Upstream 100 bases:

>100_bases
TGGCTCAATCATTGAGGCATATTTTTGCAGGCAATATATTGAATCTGAAAAGTTAAAGATGATATTTTCGGTGCAGGAGC
TATCATGTGGAGGGAGAAGT

Downstream 100 bases:

>100_bases
TGAAGTTATAAGGTTGCCTGCCAGAGGTAATCCTTCCAGCGCCATAAGACTACTCTATATTATGACTGTATGTTTCCTGA
ATAGCAGGCAAAAAAGTGTT

Product: secreted effector protein

Products: NA

Alternate protein names: Virulence factor yopJ [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MLSPTTRNMGASLSPQSDVSGELNTEALTCIVERLESEIIDGSWIHISYEETDLEMMPFLVAQANKKYPELNLKFVMSVH
ELVSSIKETRMEGVESARFIVNMGSSGIHVSVVDFRVMDGKTSVILFEPAACSAFGPALLALRTKAALEREQLPDCYFAM
VELDIQRSSSECGIFSLALAKKLHLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHTQGVQRLNEYVQANP
AAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLLKP

Sequences:

>Translated_288_residues
MLSPTTRNMGASLSPQSDVSGELNTEALTCIVERLESEIIDGSWIHISYEETDLEMMPFLVAQANKKYPELNLKFVMSVH
ELVSSIKETRMEGVESARFIVNMGSSGIHVSVVDFRVMDGKTSVILFEPAACSAFGPALLALRTKAALEREQLPDCYFAM
VELDIQRSSSECGIFSLALAKKLHLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHTQGVQRLNEYVQANP
AAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLLKP
>Mature_288_residues
MLSPTTRNMGASLSPQSDVSGELNTEALTCIVERLESEIIDGSWIHISYEETDLEMMPFLVAQANKKYPELNLKFVMSVH
ELVSSIKETRMEGVESARFIVNMGSSGIHVSVVDFRVMDGKTSVILFEPAACSAFGPALLALRTKAALEREQLPDCYFAM
VELDIQRSSSECGIFSLALAKKLHLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHTQGVQRLNEYVQANP
AAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLLKP

Specific function: Blocks the innate immune response by blocking cytokine production and inducing apoptosis in the infected cells. Inhibits the MAPK and NF-kappa-B signaling pathways by acetylating MAP2K1, MAP2K6 and probably also MAP2K3, MAP2K4 and I-kappa-B kinase on resi

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via type III secretion system (TTSS) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C55 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005083 [H]

Pfam domain/function: PF03421 YopJ [H]

EC number: NA

Molecular weight: Translated: 32289; Mature: 32289

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSPTTRNMGASLSPQSDVSGELNTEALTCIVERLESEIIDGSWIHISYEETDLEMMPFL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHH
VAQANKKYPELNLKFVMSVHELVSSIKETRMEGVESARFIVNMGSSGIHVSVVDFRVMDG
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEEEEEEECC
KTSVILFEPAACSAFGPALLALRTKAALEREQLPDCYFAMVELDIQRSSSECGIFSLALA
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEHEEEECCCCCCCCCHHHHHH
KKLHLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHTQGVQRLNEYVQANP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCCC
AAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLLKP
CCCCHHHCCCHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSPTTRNMGASLSPQSDVSGELNTEALTCIVERLESEIIDGSWIHISYEETDLEMMPFL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHH
VAQANKKYPELNLKFVMSVHELVSSIKETRMEGVESARFIVNMGSSGIHVSVVDFRVMDG
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEEEEEEECC
KTSVILFEPAACSAFGPALLALRTKAALEREQLPDCYFAMVELDIQRSSSECGIFSLALA
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEHEEEECCCCCCCCCHHHHHH
KKLHLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHTQGVQRLNEYVQANP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCCC
AAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLLKP
CCCCHHHCCCHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8045884; 1840573 [H]