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The map label for this gene is wecB [H]

Identifier: 194737283

GI number: 194737283

Start: 4007950

End: 4009080

Strand: Direct

Name: wecB [H]

Synonym: SeSA_A4131

Alternate gene names: 194737283

Gene position: 4007950-4009080 (Clockwise)

Preceding gene: 194736042

Following gene: 194734662

Centisome position: 85.11

GC content: 52.25

Gene sequence:

>1131_bases
GTGAAAGTACTGACTGTATTTGGTACACGACCGGAGGCCATTAAGATGGCGCCTCTGGTCCATGCGCTGGAAAAAGATCC
TCATTTCGAGGCCAAAGTATGCGTTACTGCGCAGCATCGGGAGATGCTTGATCAGGTATTAACTCTTTTTTCTATTGTGC
CTGATTACGATCTCAACATTATGCAGCCGGGACAGGGGTTGACGGAAATTACCTGCCGAATTCTGGAGGGATTAAAGCCG
ATCCTGGCAGATTTTAAACCTGATGTGGTGCTGGTTCATGGCGATACCACCACTACGATTGCTACCAGCCTGGCGGCTTT
CTATCAACGAATTCCGGTAGGGCACGTAGAAGCCGGGTTGCGAACCGGCGATCTCTATTCCCCCTGGCCGGAAGAGGCAA
ACCGCACGCTGACCGGACATCTGGCGATGTACCACTTTGCGCCGACGGAAAACTCGCGGCAGAATCTGTTGCGGGAGAAC
ATTCCGGATGAGCGCATTTTTGTCACTGGCAATACCGTTATCGACGCGCTGATCTGGGTACGCGATCGCGTTCTGACGAG
CGATACATTACAGGCTGAACTGGCCGAGCAGTATCCTTTCCTCAACGCGAATAAGAAGATGATTTTAGTGACCGGTCATC
GGCGTGAAAGCTTTGGTCAGGGCTTTGAGCATATCTGCCAGGCGCTGGCGGAAATCGCCGCCGCGAACCAGAATGTGCAA
ATTGTCTATCCGGTGCATCTCAATCCCAACGTCAGCGAACCTGTCAACCGTATCCTCGGCCATGTTGAAAACGTGGTACT
GATTGAGCCGCAGGACTACTTACCTTTTGTCTGGCTGATGAATCACGCCTGGCTCATTCTGACCGATTCCGGCGGTATTC
AGGAAGAAGCGCCGTCATTAGGTAAGCCGGTATTGGTCATGCGTGAAACCACAGAGCGTCCGGAAGCCATTACCGCTGGT
ACGGTAAGACTGATCGGCACGGACTCCCGGCGCATTGTGGCGGAAGTTATGCGTCTGCTGCACGACGAAAATGAATATCA
AACTATGAGCCGCGCCCATAATCCTTATGGTGACGGGCAATCATGCGCGCGCATTTTACAGGCGTTAAAAAGTTATCGGG
TATCGTTATGA

Upstream 100 bases:

>100_bases
CTAATCGGTGCGGGCGTTGCCTTAACCCGTCGCCGCACGATTTAGCAACACCTCTGCAGTAGGGGGCTGGGCCCCTGCTG
TCTATTCGAAGAGAATCGAT

Downstream 100 bases:

>100_bases
GTTTTACGACCATTTCTGTTATTGGGCTGGGGTATATCGGATTACCGACTGCGGCCGCTTTTGCTTCCTGCCAGAAGCAG
GTTATCGGCGTGGATATCAA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKVLTVFGTRPEAIKMAPLVHALEKDPHFEAKVCVTAQHREMLDQVLTLFSIVPDYDLNIMQPGQGLTEITCRILEGLKP
ILADFKPDVVLVHGDTTTTIATSLAAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAMYHFAPTENSRQNLLREN
IPDERIFVTGNTVIDALIWVRDRVLTSDTLQAELAEQYPFLNANKKMILVTGHRRESFGQGFEHICQALAEIAAANQNVQ
IVYPVHLNPNVSEPVNRILGHVENVVLIEPQDYLPFVWLMNHAWLILTDSGGIQEEAPSLGKPVLVMRETTERPEAITAG
TVRLIGTDSRRIVAEVMRLLHDENEYQTMSRAHNPYGDGQSCARILQALKSYRVSL

Sequences:

>Translated_376_residues
MKVLTVFGTRPEAIKMAPLVHALEKDPHFEAKVCVTAQHREMLDQVLTLFSIVPDYDLNIMQPGQGLTEITCRILEGLKP
ILADFKPDVVLVHGDTTTTIATSLAAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAMYHFAPTENSRQNLLREN
IPDERIFVTGNTVIDALIWVRDRVLTSDTLQAELAEQYPFLNANKKMILVTGHRRESFGQGFEHICQALAEIAAANQNVQ
IVYPVHLNPNVSEPVNRILGHVENVVLIEPQDYLPFVWLMNHAWLILTDSGGIQEEAPSLGKPVLVMRETTERPEAITAG
TVRLIGTDSRRIVAEVMRLLHDENEYQTMSRAHNPYGDGQSCARILQALKSYRVSL
>Mature_376_residues
MKVLTVFGTRPEAIKMAPLVHALEKDPHFEAKVCVTAQHREMLDQVLTLFSIVPDYDLNIMQPGQGLTEITCRILEGLKP
ILADFKPDVVLVHGDTTTTIATSLAAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAMYHFAPTENSRQNLLREN
IPDERIFVTGNTVIDALIWVRDRVLTSDTLQAELAEQYPFLNANKKMILVTGHRRESFGQGFEHICQALAEIAAANQNVQ
IVYPVHLNPNVSEPVNRILGHVENVVLIEPQDYLPFVWLMNHAWLILTDSGGIQEEAPSLGKPVLVMRETTERPEAITAG
TVRLIGTDSRRIVAEVMRLLHDENEYQTMSRAHNPYGDGQSCARILQALKSYRVSL

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=404, Percent_Identity=22.2772277227723, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4885285, Length=404, Percent_Identity=22.2772277227723, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI298566312, Length=404, Percent_Identity=22.2772277227723, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI48994967, Length=376, Percent_Identity=85.9042553191489, Blast_Score=670, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42166; Mature: 42166

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALEKDPHFEAKVCVTAQHREMLDQVLTLFSIVPDYDLNI
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEE
MQPGQGLTEITCRILEGLKPILADFKPDVVLVHGDTTTTIATSLAAFYQRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCC
RTGDLYSPWPEEANRTLTGHLAMYHFAPTENSRQNLLRENIPDERIFVTGNTVIDALIWV
CCCCCCCCCHHHHCCEEEEEEEEEEECCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHHH
RDRVLTSDTLQAELAEQYPFLNANKKMILVTGHRRESFGQGFEHICQALAEIAAANQNVQ
HHHHHCHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEE
IVYPVHLNPNVSEPVNRILGHVENVVLIEPQDYLPFVWLMNHAWLILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCHHEECCCCEEEEECCCCCCCCCCCC
GKPVLVMRETTERPEAITAGTVRLIGTDSRRIVAEVMRLLHDENEYQTMSRAHNPYGDGQ
CCCEEEEECCCCCCCEEECCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHH
SCARILQALKSYRVSL
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALEKDPHFEAKVCVTAQHREMLDQVLTLFSIVPDYDLNI
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEE
MQPGQGLTEITCRILEGLKPILADFKPDVVLVHGDTTTTIATSLAAFYQRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCC
RTGDLYSPWPEEANRTLTGHLAMYHFAPTENSRQNLLRENIPDERIFVTGNTVIDALIWV
CCCCCCCCCHHHHCCEEEEEEEEEEECCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHHH
RDRVLTSDTLQAELAEQYPFLNANKKMILVTGHRRESFGQGFEHICQALAEIAAANQNVQ
HHHHHCHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEE
IVYPVHLNPNVSEPVNRILGHVENVVLIEPQDYLPFVWLMNHAWLILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCHHEECCCCEEEEECCCCCCCCCCCC
GKPVLVMRETTERPEAITAGTVRLIGTDSRRIVAEVMRLLHDENEYQTMSRAHNPYGDGQ
CCCEEEEECCCCCCCEEECCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHH
SCARILQALKSYRVSL
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]