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The map label for this gene is ptxR [H]

Identifier: 194737137

GI number: 194737137

Start: 2959933

End: 2960844

Strand: Direct

Name: ptxR [H]

Synonym: SeSA_A3062

Alternate gene names: 194737137

Gene position: 2959933-2960844 (Clockwise)

Preceding gene: 194737683

Following gene: 194736757

Centisome position: 62.86

GC content: 55.15

Gene sequence:

>912_bases
ATGCTCAATTTGCAGCGTATGTCGCTGTTTATCGCCGTGGTAGATAGCGGCAGCTTCACGGCCGCCGCCGCCGCATCGGG
CCAAACAAAAGCGGTAGTGAGTTTTAATATTCGGCAGCTTGAAAAAGAGCTTGGCGTAACGTTACTGCTACGTTCCACCC
GACGATTGACGCTCACAGACGCCGGCGTCCTCTTTTACCAAAAAGGCGTGAATTTACTCAATGCCGCGAAAAATTTGCAG
GATGAAGTGCGTGCCAGCCATAGTGGGCTGGGCGGCGAGTTACGTATTACCACTACGCCCGAGTTTGGCGAACAGGTGGT
CATTCCGGTACTGGCGCAGTTTAGTCAGCGCCATCCCGATCTCCGTATTCGGCATATGTCCTCATCACATCATGCCGATT
TAATTGCCGAGCGCTTTGATGTGGCGATTCGGCTTGGCTCGCTGGCGGACTCCCGCTATCGCGCCGCGCTGATATCCCGC
TTTACCATTCTGCCGGTCGCCGCGCCGCAGTGGCTCGCCCGCCACCCCGTGTCGTCGCTGGAGTCGTTGGCTCAGGCGGA
ATGGATTATTCATGAGCGATTACCTACGCCGCTACGGTGGACAGTAACGAATAATCATGGCCAACACTCACGCCTGGAGA
TAAGCAAAGCCGGCAAAATTTCTGTCGACAGCGCGCGCTCGCTGATGGCCTTCGCTCTCGCGGGAAGCGGCGTCGCATTA
CTGCCGCAATGGTTAGTCAACACCGCACTGGAGGATGGAACGTTAATTCACGTGTTACCCGACTATCATTTTCCCCGTCA
GGGCATTTATGCCGTTTATCCGGACGCCCGCCATGTATCGACAAAAGTACGCGCATTTATTGATTTTTTACGTTCGCAAT
GGGATTGCGGGGAGCACGCCCCATCATTGTAG

Upstream 100 bases:

>100_bases
CTCCGTCAGAGGCGCTAATGTAGCCGTCCGGAGAAAGCCAGATAAGTCCGCGCTTCAACGATATACTGTCAAAATAATTT
TGACAGTAAAGGAGCTCGCC

Downstream 100 bases:

>100_bases
CCAGCCCGGGAGCATTGCGCTCCCGGACGGATAATACCGTCTTAATCCTTAACTACCAGCTTGTCTTTGATCCCCTGCGC
CTGCCAACGCACCCACAGCA

Product: transcriptional regulator, LysR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLLNAAKNLQ
DEVRASHSGLGGELRITTTPEFGEQVVIPVLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISR
FTILPVAAPQWLARHPVSSLESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFALAGSGVAL
LPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSL

Sequences:

>Translated_303_residues
MLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLLNAAKNLQ
DEVRASHSGLGGELRITTTPEFGEQVVIPVLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISR
FTILPVAAPQWLARHPVSSLESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFALAGSGVAL
LPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSL
>Mature_303_residues
MLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLLNAAKNLQ
DEVRASHSGLGGELRITTTPEFGEQVVIPVLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISR
FTILPVAAPQWLARHPVSSLESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFALAGSGVAL
LPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSL

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=30.9027777777778, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1789440, Length=286, Percent_Identity=31.1188811188811, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI145693193, Length=294, Percent_Identity=30.952380952381, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI87081978, Length=303, Percent_Identity=31.6831683168317, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=29.1095890410959, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1787128, Length=303, Percent_Identity=26.0726072607261, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787589, Length=292, Percent_Identity=28.4246575342466, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788706, Length=302, Percent_Identity=24.8344370860927, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788481, Length=297, Percent_Identity=26.2626262626263, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1786713, Length=275, Percent_Identity=25.8181818181818, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786448, Length=319, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789173, Length=284, Percent_Identity=26.4084507042254, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI157672245, Length=194, Percent_Identity=32.9896907216495, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787601, Length=217, Percent_Identity=23.963133640553, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082024, Length=266, Percent_Identity=24.0601503759398, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33492; Mature: 33492

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTD
CCCHHEEEEEEEEECCCCCEEEECCCCCCEEEEEHHHHHHHHHHCEEEEEECCCEEEEEC
AGVLFYQKGVNLLNAAKNLQDEVRASHSGLGGELRITTTPEFGEQVVIPVLAQFSQRHPD
CCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCC
LRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISRFTILPVAAPQWLARHPVSSL
EEEEECCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHEEEECCCHHHHHHCCHHHH
ESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFALAGSGVAL
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCEEHHHHHHHHHHHHCCCCHHH
LPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHA
HHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCC
PSL
CCC
>Mature Secondary Structure
MLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTD
CCCHHEEEEEEEEECCCCCEEEECCCCCCEEEEEHHHHHHHHHHCEEEEEECCCEEEEEC
AGVLFYQKGVNLLNAAKNLQDEVRASHSGLGGELRITTTPEFGEQVVIPVLAQFSQRHPD
CCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCC
LRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISRFTILPVAAPQWLARHPVSSL
EEEEECCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHEEEECCCHHHHHHCCHHHH
ESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFALAGSGVAL
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCEEHHHHHHHHHHHHCCCCHHH
LPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHA
HHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCC
PSL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]