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The map label for this gene is fes [H]

Identifier: 194737015

GI number: 194737015

Start: 2828458

End: 2829702

Strand: Direct

Name: fes [H]

Synonym: SeSA_A2917

Alternate gene names: 194737015

Gene position: 2828458-2829702 (Clockwise)

Preceding gene: 194737835

Following gene: 194736307

Centisome position: 60.06

GC content: 62.09

Gene sequence:

>1245_bases
ATGAGACTGAGCCCGCCCGTCGCTCCTGTCGCTATACAGACCGCTACGCGCCTTCGCCGCCAACTCGCCGCCGGAAGCCA
GGTTGACGCTTCTCACTTCTGGCGAGAAGCAAACTCGCTCGCGCTGCCGCTGGTGACAGCCATTAACGGCGCAGACGATG
AACGGGAAGTCACCTTCCTGTGGCGTGCCGCCTCTCCTCTGCGGGGGGTTTATGTTCGCCTGAACCGTGTCACCGATAAA
GATAACGTGGCGAAAGGTATGATGACGCAACTGCCCACAACGGATATCTGGCATCTGACGCTTCGCTTACCAGCGTCCTA
CTGCGGTTCCTATACGATGGTCGAAATACCACCGGAAACCCCGGACGAGACGGTGTTGCAGCTTGGAAGCCGTTTCGCCT
CCCTTGTCGGGAAGGCGGACCCGCTGAACAGCACGCCGGGAATAAATGTTCGGGGCAATGCGCAGGAATCCGTTCTGGCG
CTGGATCACGCCCCGGCACAGGAGGAGTGGTCAGGCTGTCGCGCTTACGCCGGGCAGCTTTTCACCTCAGAACATCGGCT
CGCCGGACAACGTCGCCGTGTGCGGCTGTATCTTCCTGACGTTCCTGTCGTACAACCGCTGGGCTTACTGGTACTCACGG
ATGGCGAGATCTGGTTCGACCATCTTGGGGTAAGTGCCGCCATTGACGCTGCCATCCGCAGCGGACGCATCGCGCCGGTG
GCCGTACTCGGCATTGATAACATCAACGCGCGTGAACGCGTCGCAATCCTCGGCGGTCGCCGCGAGCTGGTGCTCGACAT
TGCCGAACGCCTGCTGCCAGCCCTTCGCGCCAAATACCCGGAACGGCGGTGGGCGGACCGTACACAAACGGTGCTGGCAG
GGCAAAGCCTCGGCGGCGTGACCGCGCTGATGGCGGCCCGCCACGCGCCAGAGAGCTTCGGCCTGGTGCTGAGCCACTCC
CCCTCAATGTGGTGGACGCCGGACAACCGCAATCGCCCGGACCATTTCAGCGCAGAAGAGCGTTCATGGGTCAGCGAACA
TGTGTTATCCGCGCCCTCGCCAGCCGTACGTACGCATCTGTGCGTGGGATCGCTGGAAGGTTCGACGGTCCCGCAGGTCA
AACAGTTGCATGAAAAATTGCGCGCCGCCGGCGTCGAAAGCCATTGCAGCGTGTACACCGGCGGTCACGATTATGCCTGG
TGGCGCGGCGCGCTGATTGACGGATTACGTCTACTGCCCCGATAA

Upstream 100 bases:

>100_bases
CCACGATTTACGCAAAAGAAAGCCCGCAAGCGGCTGTTCCTGTAACAGCCGCTTTAGCTATTGATACTGACCGAAATATA
AATGAGATGGAATACAAAGA

Downstream 100 bases:

>100_bases
AACTTCACCTGCCAAAAAGGAATCACATCCGATGTATGGTCGCCAGTACCACAACAAGTGCTATCGCATGGCGCTATTTT
TAGTGAGTTTTTGTTTTAGC

Product: enterochelin esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MRLSPPVAPVAIQTATRLRRQLAAGSQVDASHFWREANSLALPLVTAINGADDEREVTFLWRAASPLRGVYVRLNRVTDK
DNVAKGMMTQLPTTDIWHLTLRLPASYCGSYTMVEIPPETPDETVLQLGSRFASLVGKADPLNSTPGINVRGNAQESVLA
LDHAPAQEEWSGCRAYAGQLFTSEHRLAGQRRRVRLYLPDVPVVQPLGLLVLTDGEIWFDHLGVSAAIDAAIRSGRIAPV
AVLGIDNINARERVAILGGRRELVLDIAERLLPALRAKYPERRWADRTQTVLAGQSLGGVTALMAARHAPESFGLVLSHS
PSMWWTPDNRNRPDHFSAEERSWVSEHVLSAPSPAVRTHLCVGSLEGSTVPQVKQLHEKLRAAGVESHCSVYTGGHDYAW
WRGALIDGLRLLPR

Sequences:

>Translated_414_residues
MRLSPPVAPVAIQTATRLRRQLAAGSQVDASHFWREANSLALPLVTAINGADDEREVTFLWRAASPLRGVYVRLNRVTDK
DNVAKGMMTQLPTTDIWHLTLRLPASYCGSYTMVEIPPETPDETVLQLGSRFASLVGKADPLNSTPGINVRGNAQESVLA
LDHAPAQEEWSGCRAYAGQLFTSEHRLAGQRRRVRLYLPDVPVVQPLGLLVLTDGEIWFDHLGVSAAIDAAIRSGRIAPV
AVLGIDNINARERVAILGGRRELVLDIAERLLPALRAKYPERRWADRTQTVLAGQSLGGVTALMAARHAPESFGLVLSHS
PSMWWTPDNRNRPDHFSAEERSWVSEHVLSAPSPAVRTHLCVGSLEGSTVPQVKQLHEKLRAAGVESHCSVYTGGHDYAW
WRGALIDGLRLLPR
>Mature_414_residues
MRLSPPVAPVAIQTATRLRRQLAAGSQVDASHFWREANSLALPLVTAINGADDEREVTFLWRAASPLRGVYVRLNRVTDK
DNVAKGMMTQLPTTDIWHLTLRLPASYCGSYTMVEIPPETPDETVLQLGSRFASLVGKADPLNSTPGINVRGNAQESVLA
LDHAPAQEEWSGCRAYAGQLFTSEHRLAGQRRRVRLYLPDVPVVQPLGLLVLTDGEIWFDHLGVSAAIDAAIRSGRIAPV
AVLGIDNINARERVAILGGRRELVLDIAERLLPALRAKYPERRWADRTQTVLAGQSLGGVTALMAARHAPESFGLVLSHS
PSMWWTPDNRNRPDHFSAEERSWVSEHVLSAPSPAVRTHLCVGSLEGSTVPQVKQLHEKLRAAGVESHCSVYTGGHDYAW
WRGALIDGLRLLPR

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=374, Percent_Identity=31.0160427807487, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 45459; Mature: 45459

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSPPVAPVAIQTATRLRRQLAAGSQVDASHFWREANSLALPLVTAINGADDEREVTFL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEHHEEECCCCCCCEEEEE
WRAASPLRGVYVRLNRVTDKDNVAKGMMTQLPTTDIWHLTLRLPASYCGSYTMVEIPPET
EECCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCHHHCCCEEEEECCCCC
PDETVLQLGSRFASLVGKADPLNSTPGINVRGNAQESVLALDHAPAQEEWSGCRAYAGQL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHHHH
FTSEHRLAGQRRRVRLYLPDVPVVQPLGLLVLTDGEIWFDHLGVSAAIDAAIRSGRIAPV
HCCHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEHHCCHHHHHHHHHHCCCCCEE
AVLGIDNINARERVAILGGRRELVLDIAERLLPALRAKYPERRWADRTQTVLAGQSLGGV
EEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHH
TALMAARHAPESFGLVLSHSPSMWWTPDNRNRPDHFSAEERSWVSEHVLSAPSPAVRTHL
HHHHHHHCCCHHCCEEEECCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHEE
CVGSLEGSTVPQVKQLHEKLRAAGVESHCSVYTGGHDYAWWRGALIDGLRLLPR
EEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLSPPVAPVAIQTATRLRRQLAAGSQVDASHFWREANSLALPLVTAINGADDEREVTFL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEHHEEECCCCCCCEEEEE
WRAASPLRGVYVRLNRVTDKDNVAKGMMTQLPTTDIWHLTLRLPASYCGSYTMVEIPPET
EECCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCHHHCCCEEEEECCCCC
PDETVLQLGSRFASLVGKADPLNSTPGINVRGNAQESVLALDHAPAQEEWSGCRAYAGQL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHHHH
FTSEHRLAGQRRRVRLYLPDVPVVQPLGLLVLTDGEIWFDHLGVSAAIDAAIRSGRIAPV
HCCHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEHHCCHHHHHHHHHHCCCCCEE
AVLGIDNINARERVAILGGRRELVLDIAERLLPALRAKYPERRWADRTQTVLAGQSLGGV
EEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHH
TALMAARHAPESFGLVLSHSPSMWWTPDNRNRPDHFSAEERSWVSEHVLSAPSPAVRTHL
HHHHHHHCCCHHCCEEEECCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHEE
CVGSLEGSTVPQVKQLHEKLRAAGVESHCSVYTGGHDYAWWRGALIDGLRLLPR
EEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA