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The map label for this gene is zraR [H]

Identifier: 194736973

GI number: 194736973

Start: 4255841

End: 4257166

Strand: Direct

Name: zraR [H]

Synonym: SeSA_A4385

Alternate gene names: 194736973

Gene position: 4255841-4257166 (Clockwise)

Preceding gene: 194737287

Following gene: 194737721

Centisome position: 90.38

GC content: 55.43

Gene sequence:

>1326_bases
GTGATACGCGGAAAAATCGATATTCTGGTTGTGGATGATGATGTAAGCCACTGCACGATTTTACAGGCTCTGCTTCGGGG
TTGGGGCTATAACGTCGCTCTGGCCTACAGTGGGCATGATGCGTTGGCTCAGGTGCGTGAGAAAGTCTTTGATCTGGTAC
TGTGCGATGTGCGTATGGCGGAGATGGACGGTATCGCCACGCTGAAGGAGATTAAAGCGCTCAACCCCGCCATTCCGATT
TTGATTATGACGGCATTCTCCAGCGTGGAAACGGCGGTAGAGGCGTTGAAAGCCGGCGCGCTCGACTATTTAATTAAACC
GCTGGATTTTGACCGTCTGCAGGAGACGCTGGAAAAGGCGTTGGCGCATACGCGGGAAACGGGCGCTGAATTGCCATCGG
CGTCGGCTGCGCAGTTTGGCATGATTGGCAGCAGTCCGGCGATGCAACATTTACTGAATGAAATCGCGATGGTCGCACCA
TCAGACGCCACGGTATTGATTCACGGAGACTCCGGCACGGGTAAAGAGCTGGTGGCGCGGGCGCTACACGCCTGTAGCGC
CAGGAGCGATAGACCGCTGGTCACGCTCAACTGCGCCGCGCTTAATGAATCGCTGCTGGAGTCTGAGCTGTTCGGACACG
AAAAAGGCGCGTTTACCGGCGCGGATAAACGTCGGGAGGGACGCTTTGTCGAAGCTGACGGCGGGACATTGTTTCTTGAT
GAAATCGGCGATATCTCGCCGTTAATGCAGGTACGTTTGCTGCGGGCGATTCAGGAGCGCGAAGTGCAACGCGTGGGAAG
TAACCAGACGATATCTGTGGATGTTCGGTTAATTGCCGCTACCCACCGCGATCTGGCGGAAGAGGTAAGTGCCGGTCGCT
TTCGCCAGGATCTCTATTACCGCCTGAATGTGGTGGCGATTGAAATGCCTTCTTTGCGCCAGCGTCGGGAAGATATTCCG
CTACTGGCAGACCATTTTCTGCGGCGTTTTGCCGAACGTAACCGCAAAGCGGTGAAGGGGTTTACGCCGCAGGCGATGGA
TCTGCTGATCCACTACGACTGGCCGGGCAATATCCGTGAGCTGGAAAACGCTATCGAGCGGGCGGTGGTGTTGCTAACGG
GAGAATACATTTCTGAACGCGAATTGCCTCTCGCTATTGCCGCGACGCCGATAAAAACGGAATACAGTGGTGAGATCCAA
CCGTTGGTCGATGTGGAAAAAGAGATCATTCTGGCGGCGCTGGAAAAAACGGGCGGCAACAAAACGGAAGCCGCCCGCCA
ATTGGGCATTACGCGCAAAACGCTGCTGGCTAAACTCAGCCGTTAG

Upstream 100 bases:

>100_bases
AACAGCATGGCGGCGCGATTAAGGTGAAAAGTATTGAGGGTAAAGGCGCGGTCTTTACTATCTGGTTGCCAGTGATAGCG
AGACAACAGGATTAACAAGG

Downstream 100 bases:

>100_bases
TTTTGCTCACGCTCGATGGCGCGCCAGCCGATGTCGTTACGGCTGAAGCTGCCGTCCCAGCGGATGTCGGTCATCAGAGC
GTAAGCGCGTTTCTGCGCCT

Product: transcriptional regulatory protein ZraR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MIRGKIDILVVDDDVSHCTILQALLRGWGYNVALAYSGHDALAQVREKVFDLVLCDVRMAEMDGIATLKEIKALNPAIPI
LIMTAFSSVETAVEALKAGALDYLIKPLDFDRLQETLEKALAHTRETGAELPSASAAQFGMIGSSPAMQHLLNEIAMVAP
SDATVLIHGDSGTGKELVARALHACSARSDRPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
EIGDISPLMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAEEVSAGRFRQDLYYRLNVVAIEMPSLRQRREDIP
LLADHFLRRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAIERAVVLLTGEYISERELPLAIAATPIKTEYSGEIQ
PLVDVEKEIILAALEKTGGNKTEAARQLGITRKTLLAKLSR

Sequences:

>Translated_441_residues
MIRGKIDILVVDDDVSHCTILQALLRGWGYNVALAYSGHDALAQVREKVFDLVLCDVRMAEMDGIATLKEIKALNPAIPI
LIMTAFSSVETAVEALKAGALDYLIKPLDFDRLQETLEKALAHTRETGAELPSASAAQFGMIGSSPAMQHLLNEIAMVAP
SDATVLIHGDSGTGKELVARALHACSARSDRPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
EIGDISPLMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAEEVSAGRFRQDLYYRLNVVAIEMPSLRQRREDIP
LLADHFLRRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAIERAVVLLTGEYISERELPLAIAATPIKTEYSGEIQ
PLVDVEKEIILAALEKTGGNKTEAARQLGITRKTLLAKLSR
>Mature_441_residues
MIRGKIDILVVDDDVSHCTILQALLRGWGYNVALAYSGHDALAQVREKVFDLVLCDVRMAEMDGIATLKEIKALNPAIPI
LIMTAFSSVETAVEALKAGALDYLIKPLDFDRLQETLEKALAHTRETGAELPSASAAQFGMIGSSPAMQHLLNEIAMVAP
SDATVLIHGDSGTGKELVARALHACSARSDRPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
EIGDISPLMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAEEVSAGRFRQDLYYRLNVVAIEMPSLRQRREDIP
LLADHFLRRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAIERAVVLLTGEYISERELPLAIAATPIKTEYSGEIQ
PLVDVEKEIILAALEKTGGNKTEAARQLGITRKTLLAKLSR

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=88.6621315192744, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=446, Percent_Identity=47.9820627802691, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788905, Length=438, Percent_Identity=43.8356164383562, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI1790299, Length=461, Percent_Identity=41.648590021692, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI87082117, Length=315, Percent_Identity=48.2539682539683, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1789087, Length=309, Percent_Identity=47.5728155339806, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87082152, Length=328, Percent_Identity=46.3414634146341, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789233, Length=336, Percent_Identity=40.4761904761905, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1786524, Length=319, Percent_Identity=42.9467084639498, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=42.1383647798742, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1787583, Length=337, Percent_Identity=36.2017804154303, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=37.7510040160643, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081858, Length=347, Percent_Identity=30.5475504322767, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789149, Length=112, Percent_Identity=33.9285714285714, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=36.0655737704918, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48577; Mature: 48577

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRGKIDILVVDDDVSHCTILQALLRGWGYNVALAYSGHDALAQVREKVFDLVLCDVRMA
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
EMDGIATLKEIKALNPAIPILIMTAFSSVETAVEALKAGALDYLIKPLDFDRLQETLEKA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHH
LAHTRETGAELPSASAAQFGMIGSSPAMQHLLNEIAMVAPSDATVLIHGDSGTGKELVAR
HHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
ALHACSARSDRPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEC
EIGDISPLMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAEEVSAGRFRQDLYY
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHE
RLNVVAIEMPSLRQRREDIPLLADHFLRRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRE
EEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCCCHHH
LENAIERAVVLLTGEYISERELPLAIAATPIKTEYSGEIQPLVDVEKEIILAALEKTGGN
HHHHHHHEEEEEECCHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
KTEAARQLGITRKTLLAKLSR
HHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MIRGKIDILVVDDDVSHCTILQALLRGWGYNVALAYSGHDALAQVREKVFDLVLCDVRMA
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
EMDGIATLKEIKALNPAIPILIMTAFSSVETAVEALKAGALDYLIKPLDFDRLQETLEKA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHH
LAHTRETGAELPSASAAQFGMIGSSPAMQHLLNEIAMVAPSDATVLIHGDSGTGKELVAR
HHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
ALHACSARSDRPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEC
EIGDISPLMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAEEVSAGRFRQDLYY
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHE
RLNVVAIEMPSLRQRREDIPLLADHFLRRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRE
EEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCCCHHH
LENAIERAVVLLTGEYISERELPLAIAATPIKTEYSGEIQPLVDVEKEIILAALEKTGGN
HHHHHHHEEEEEECCHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
KTEAARQLGITRKTLLAKLSR
HHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]