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The map label for this gene is ubiA [H]

Identifier: 194736960

GI number: 194736960

Start: 4305718

End: 4306590

Strand: Direct

Name: ubiA [H]

Synonym: SeSA_A4426

Alternate gene names: 194736960

Gene position: 4305718-4306590 (Clockwise)

Preceding gene: 194736344

Following gene: 194737785

Centisome position: 91.43

GC content: 54.64

Gene sequence:

>873_bases
ATGGAGTGGAGTCTGACGCAGAGTAAGCTGCTGGCGTTTCACCGTTTGATGCGTACAGATAAGCCTATTGGCGCGTTGCT
GCTGCTCTGGCCGACGCTTTGGGCGCTATGGGTGGCGACACCGGGTATGCCTCAGCTGTGGATTTTGGCGGTTTTTGTCG
CTGGCGTGTGGTTAATGCGCGCGGCGGGCTGCGTGGTAAATGATTATGCCGATCGTAAATTTGACGGACATGTAAAACGT
ACGGTCAACCGGCCTTTACCCAGCGGCGCCGTGACAGAGAAAGAAGCGCGCAACCTGTTTGTGGTACTGGTGCTGCTGGC
GTTTCTGTTGGTGCTGACGCTGAACGCGATGACGATTCTGCTTTCCGTGGCGGCGTTGGCGTTGGCCTGGGTTTATCCCT
TTATGAAACGCTACACCCACCTGCCGCAGGTCGTGCTGGGGGCCGCTTTCGGCTGGTCAATCCCCATGGCGTTCGCCGCG
GTGAGCGAATCCCTGCCGTTGAGCTGCTGGCTGATGTTCCTCGCCAATATTCTCTGGGCGGTGGCTTACGATACGCAATA
TGCGATGGTCGACAGAGATGATGATATCAAGATAGGCATTAAATCGACGGCGATCCTGTTTGGTCGTTATGACACATTGA
TTATCGGGATTCTGCAGCTTGGCGTCATGGCGTTAATGGCGCTGATCGGCTGGTTGAATGGTCTGGGATGGGGATATTAC
TGGGCTGTGCTGGTGGCGGGCGCGCTGTTTGTCTACCAGCAAAAACTGATTGCGAACCGTGAACGTGAAGCCTGCTTTAA
AGCCTTTATGAACAATAACTACGTTGGCCTGGTGCTATTTTTAGGGCTGGCGATGAGTTACTGGCACTTCTGA

Upstream 100 bases:

>100_bases
CTATGGGGGCGCCGCTCTCGACTGCGGTTGAGCGGAAAACCGCTGTTGCTTACCGAGCTTTTTTTACCTGCATCGCCGCT
GTACTGAGAGGAAGATAAAG

Downstream 100 bases:

>100_bases
TGTCATGCCGGGCGGACCCGGCCTACAAAGCCAAAATTTTCAATACGTCATATCAGTTGCCCGATAAGCTTACGCCATCG
GGCATTTCAGGCACTGGCTT

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MEWSLTQSKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGMPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TVNRPLPSGAVTEKEARNLFVVLVLLAFLLVLTLNAMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESLPLSCWLMFLANILWAVAYDTQYAMVDRDDDIKIGIKSTAILFGRYDTLIIGILQLGVMALMALIGWLNGLGWGYY
WAVLVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Sequences:

>Translated_290_residues
MEWSLTQSKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGMPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TVNRPLPSGAVTEKEARNLFVVLVLLAFLLVLTLNAMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESLPLSCWLMFLANILWAVAYDTQYAMVDRDDDIKIGIKSTAILFGRYDTLIIGILQLGVMALMALIGWLNGLGWGYY
WAVLVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
>Mature_290_residues
MEWSLTQSKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGMPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TVNRPLPSGAVTEKEARNLFVVLVLLAFLLVLTLNAMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESLPLSCWLMFLANILWAVAYDTQYAMVDRDDDIKIGIKSTAILFGRYDTLIIGILQLGVMALMALIGWLNGLGWGYY
WAVLVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=280, Percent_Identity=34.6428571428571, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1790473, Length=290, Percent_Identity=93.7931034482759, Blast_Score=538, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI32565247, Length=281, Percent_Identity=37.0106761565836, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17553718, Length=281, Percent_Identity=36.6548042704626, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17553720, Length=340, Percent_Identity=29.7058823529412, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=43.9716312056738, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32565243, Length=140, Percent_Identity=43.5714285714286, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324370, Length=300, Percent_Identity=33, Blast_Score=143, Evalue=4e-35,
Organism=Drosophila melanogaster, GI21355567, Length=276, Percent_Identity=36.9565217391304, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32602; Mature: 32602

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWSLTQSKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGMPQLWILAVFVAGVWLMR
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAGCVVNDYADRKFDGHVKRTVNRPLPSGAVTEKEARNLFVVLVLLAFLLVLTLNAMTIL
HCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESLPLSCWLMFLANILWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAYDTQYAMVDRDDDIKIGIKSTAILFGRYDTLIIGILQLGVMALMALIGWLNGLGWGYY
HHHCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
WAVLVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEWSLTQSKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGMPQLWILAVFVAGVWLMR
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAGCVVNDYADRKFDGHVKRTVNRPLPSGAVTEKEARNLFVVLVLLAFLLVLTLNAMTIL
HCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESLPLSCWLMFLANILWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAYDTQYAMVDRDDDIKIGIKSTAILFGRYDTLIIGILQLGVMALMALIGWLNGLGWGYY
HHHCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
WAVLVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA