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The map label for this gene is yihU [H]

Identifier: 194736938

GI number: 194736938

Start: 4112101

End: 4112997

Strand: Reverse

Name: yihU [H]

Synonym: SeSA_A4233

Alternate gene names: 194736938

Gene position: 4112997-4112101 (Counterclockwise)

Preceding gene: 194735908

Following gene: 194736335

Centisome position: 87.34

GC content: 56.3

Gene sequence:

>897_bases
ATGGCAGTTATAGCATTTATCGGGTTGGGACAGATGGGCTCTCCTATGGCGAGCAATCTGCTAAAGCAGGGCCATCAACT
CAGCGTCTTCGATGTTAATCACGACGCCGTACAGCGTCTGGTAGACAAAGGCGCGCAACCTGCAAGCAGCCCGGCTCAGG
CAACCATCGGCGCTGAATTTGTTATCACCATGCTCCCGAACGGCGATCTGGTTCGTTCCGTTTTGTTTGGCGAGCAAGGC
GTTTGTGAAACTCTTTCCCGTGAAGCGCTGGTCATTGATATGTCCACTATTCATCCGTTGCAAACCGATAAGCTGATTGC
CGACATGCAGAGCAAAGGGTTCAGCATGATGGATGTGCCGGTAGGCCGGACATCCGACAACGCGATTACCGGCACATTGT
TGCTGCTGGCAGGCGGTACGGCGGAGCAAGTAGAGCGCGCTACCCCTGTTCTGATGGCGATGGGTAATGAGCTGGTCAAC
ACCGGCGGCCCGGGAATGGGTATTCGCGTAAAACTGATCAACAACTACATGAGTATTGCGCTAAATGCGCTCTCCGCCGA
AGCCGCCGTGCTGTGTGAAGCGCTGAGGCTTTCCTTCGACGTGGCTTTAAAAGTGATGAGCGGCACTGCCGCAGGCAAAG
GGCATTTCACCACCACCTGGCCGAATAAAGTGATGAAAGGGGATCTGTCTCCCGCCTTCATGATCGATCTGGCGCACAAA
GATCTTGGCATCGCGTTGGATGTCGCCAATCAACTGCACGTACCGATGCCGCTCGGTGCCGCCTCCCGGGAAGTTTATAA
CCTGGCGCGGGCCGCAGGCCGCGGTCGGGAAGACTGGAGCGCCATCCTGGAGCAGGTGCGCATCAGCGCCGGGCTGACCG
CCAACGTAAAAAAGTAA

Upstream 100 bases:

>100_bases
CTGTCAATTTTTTGACTATAAATTACAAATACGATCACAAACAGACAGAAAAAGGCTCATTAATGACAAAAAATGACACC
ACCGTGTTCAGGAGAACGAT

Downstream 100 bases:

>100_bases
CGACTGTATAAAGGAAAATTGAATGAACAACTACACCATCAAAGACATTACGCGAGCGTCCGGCGGGTTTGCCATGCTGG
CTGTCGATCAGCGCGAGGCG

Product: 3-hydroxyisobutyrate dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNHDAVQRLVDKGAQPASSPAQATIGAEFVITMLPNGDLVRSVLFGEQG
VCETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVPVGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVN
TGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALRLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK

Sequences:

>Translated_298_residues
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNHDAVQRLVDKGAQPASSPAQATIGAEFVITMLPNGDLVRSVLFGEQG
VCETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVPVGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVN
TGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALRLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
>Mature_297_residues
AVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNHDAVQRLVDKGAQPASSPAQATIGAEFVITMLPNGDLVRSVLFGEQGV
CETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVPVGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVNT
GGPGMGIRVKLINNYMSIALNALSAEAAVLCEALRLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHKD
LGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=295, Percent_Identity=33.2203389830508, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=25.3521126760563, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1790315, Length=297, Percent_Identity=87.5420875420875, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=36.4285714285714, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=30.7958477508651, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=30.7167235494881, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17557316, Length=301, Percent_Identity=28.2392026578073, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=32.1917808219178, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=32.1917808219178, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574115, Length=289, Percent_Identity=23.8754325259516, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24655240, Length=64, Percent_Identity=50, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.-.- [C]

Molecular weight: Translated: 31420; Mature: 31289

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNHDAVQRLVDKGAQPASSPAQATIGAEF
CEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEE
VITMLPNGDLVRSVLFGEQGVCETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVP
EEEECCCCHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECC
VGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVNTGGPGMGIRVKLINNYMSIA
CCCCCCCCEEEEEEEEECCCHHHHHHHCHHHHHHCCHHHHCCCCCCCEEEEEHHHHHHHH
LNALSAEAAVLCEALRLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHCCCCCCEEEEEECCC
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
AVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNHDAVQRLVDKGAQPASSPAQATIGAEF
EEEEEECCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEE
VITMLPNGDLVRSVLFGEQGVCETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVP
EEEECCCCHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECC
VGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVNTGGPGMGIRVKLINNYMSIA
CCCCCCCCEEEEEEEEECCCHHHHHHHCHHHHHHCCHHHHCCCCCCCEEEEEHHHHHHHH
LNALSAEAAVLCEALRLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHCCCCCCEEEEEECCC
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]