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The map label for this gene is pgtA

Identifier: 194736936

GI number: 194736936

Start: 2509967

End: 2511214

Strand: Reverse

Name: pgtA

Synonym: SeSA_A2625

Alternate gene names: 194736936

Gene position: 2511214-2509967 (Counterclockwise)

Preceding gene: 194735732

Following gene: 194736399

Centisome position: 53.33

GC content: 51.68

Gene sequence:

>1248_bases
ATGTTGAATGATGAATGTTCTATTTTGCTGATTGATGATGACGTTGATGTACTTGACGCCTATACCCAAATGCTTGAGCA
GGCAGGCTACCGCGTGCGTGGCTTTACCCATCCTTTCGAGGCCAAAGAGTGGGTAAAAGCGGATTGGGAGGGGATCGTTT
TGAGCGATGTATGTATGCCGGGGTGTTCCGGTATCGATCTTATGACGCTGTTTCATCAGGATGACGATCAACTGCCAATC
TTATTGATTACCGGACATGGCGATGTACCGATGGCGGTTGATGCGGTGAAAAAGGGCGCCTGGGATTTTCTGCAAAAACC
CGTCGATCCGGGCAAGCTGTTGATATTAATTGAAGACGCGCTACGCCAGCGCCGGTCGGTCATTGCACGGCGGCAATATT
GCCAGCAGACGTTACAGGTTGAACTGATTGGGCGCAGCGAGTGGATGAATCAGTTTCGACAACGGTTACAACAACTGGCG
GAAACGGACATTGCCGTATGGTTTTACGGTGAGCATGGCACTGGACGTATGACTGGCGCCCGTTATCTCCATCAACTGGG
GCGTAACGCGAAAGGGCCGTTTGTACGCTATGAACTCACGCCGGAGAATGCCGGGCAGTTGGAGACATTCATCGACCAGG
CGCAAGGAGGTACGCTGGTGTTGAGTCATCCCGAATATCTGACACGCGAACAGCAGCACCATCTGGCGCGTTTACAAAGC
CTGGAGCATCGGCCTTTTCGTTTGGTGGGCGTTGGCAGCGCTTCGCTGGTGGAGCAGGCGGCAGCTAACCAGATTGCGGC
CGAGCTTTACTACTGTTTCGCCATGACCCAAATCGCCTGCCAGTCTCTTTCTCAGCGACCGGATGATATCGAGCCGTTAT
TTCGCCATTATCTTCGAAAAGCCTGCCTGCGACTCAATCATCCCGTGCCGGAAATAGCGGGGGAATTACTGAAAGGAATA
ATGCGACGCGCCTGGCCAAGCAATGTGCGCGAACTGGCTAATGCGGCAGAGCTTTTTGCTGTTGGCGTGCTGCCGCTGGC
GGAAACGGTCAACCCGCAGTTGCTTCTTCAGGAGCCGACCCCGCTTGACCGGCGCGTTGAAGAGTATGAGCGACAAATTA
TTACCGAAGCATTAAATATTCATCAGGGACGAATTAATGAAGTGGCGGAGTACCTGCAAATTCCCCGTAAAAAACTTTAT
CTGCGCATGAAAAAATATGGTTTAAGTAAAGAGCATTATAAATTCTGA

Upstream 100 bases:

>100_bases
GTGTCGCTGATGGCGCAAATGAAGGGCGACCTGCGTCTGGCGTCGACGCTGACGCGTAACGCTTGCGTGGTGCTGCAATT
CTCGGTAACGGATGTCGATG

Downstream 100 bases:

>100_bases
TATTACAGTTACTTTCAATCTGGCTGACAACATCAGCAACGATGTCGTTAGCCAGATAACGCCGCATCACCGTAATGGTA
AATCATTCCATCATGATTAT

Product: phosphoglycerate transport system transcriptional regulatory proteinpgtA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLNDECSILLIDDDVDVLDAYTQMLEQAGYRVRGFTHPFEAKEWVKADWEGIVLSDVCMPGCSGIDLMTLFHQDDDQLPI
LLITGHGDVPMAVDAVKKGAWDFLQKPVDPGKLLILIEDALRQRRSVIARRQYCQQTLQVELIGRSEWMNQFRQRLQQLA
ETDIAVWFYGEHGTGRMTGARYLHQLGRNAKGPFVRYELTPENAGQLETFIDQAQGGTLVLSHPEYLTREQQHHLARLQS
LEHRPFRLVGVGSASLVEQAAANQIAAELYYCFAMTQIACQSLSQRPDDIEPLFRHYLRKACLRLNHPVPEIAGELLKGI
MRRAWPSNVRELANAAELFAVGVLPLAETVNPQLLLQEPTPLDRRVEEYERQIITEALNIHQGRINEVAEYLQIPRKKLY
LRMKKYGLSKEHYKF

Sequences:

>Translated_415_residues
MLNDECSILLIDDDVDVLDAYTQMLEQAGYRVRGFTHPFEAKEWVKADWEGIVLSDVCMPGCSGIDLMTLFHQDDDQLPI
LLITGHGDVPMAVDAVKKGAWDFLQKPVDPGKLLILIEDALRQRRSVIARRQYCQQTLQVELIGRSEWMNQFRQRLQQLA
ETDIAVWFYGEHGTGRMTGARYLHQLGRNAKGPFVRYELTPENAGQLETFIDQAQGGTLVLSHPEYLTREQQHHLARLQS
LEHRPFRLVGVGSASLVEQAAANQIAAELYYCFAMTQIACQSLSQRPDDIEPLFRHYLRKACLRLNHPVPEIAGELLKGI
MRRAWPSNVRELANAAELFAVGVLPLAETVNPQLLLQEPTPLDRRVEEYERQIITEALNIHQGRINEVAEYLQIPRKKLY
LRMKKYGLSKEHYKF
>Mature_415_residues
MLNDECSILLIDDDVDVLDAYTQMLEQAGYRVRGFTHPFEAKEWVKADWEGIVLSDVCMPGCSGIDLMTLFHQDDDQLPI
LLITGHGDVPMAVDAVKKGAWDFLQKPVDPGKLLILIEDALRQRRSVIARRQYCQQTLQVELIGRSEWMNQFRQRLQQLA
ETDIAVWFYGEHGTGRMTGARYLHQLGRNAKGPFVRYELTPENAGQLETFIDQAQGGTLVLSHPEYLTREQQHHLARLQS
LEHRPFRLVGVGSASLVEQAAANQIAAELYYCFAMTQIACQSLSQRPDDIEPLFRHYLRKACLRLNHPVPEIAGELLKGI
MRRAWPSNVRELANAAELFAVGVLPLAETVNPQLLLQEPTPLDRRVEEYERQIITEALNIHQGRINEVAEYLQIPRKKLY
LRMKKYGLSKEHYKF

Specific function: Member of the two-component regulatory system pgtB/pgtA that regulates the inducible phosphoglycerate transport system. When activated by pgtB it acts in conjunction with sigma-54 as a transcriptional activator

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain

Homologues:

Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=26.9058295964126, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1790299, Length=471, Percent_Identity=25.0530785562633, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788905, Length=450, Percent_Identity=26.4444444444444, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=23.956043956044, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=26.791277258567, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789087, Length=314, Percent_Identity=29.2993630573248, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI87082117, Length=322, Percent_Identity=25.4658385093168, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081858, Length=299, Percent_Identity=25.0836120401338, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787583, Length=309, Percent_Identity=24.2718446601942, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGTA_SALTY (P06184)

Other databases:

- EMBL:   M13923
- EMBL:   AE006468
- EMBL:   M21279
- PIR:   A28255
- RefSeq:   NP_461337.1
- ProteinModelPortal:   P06184
- SMR:   P06184
- PRIDE:   P06184
- GeneID:   1253918
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2396
- NMPDR:   fig|99287.1.peg.2318
- HOGENOM:   HBG740884
- OMA:   DIYMPAM
- ProtClustDB:   CLSK894309
- BioCyc:   STYP99287:STM2396-MONOMER
- GO:   GO:0005737
- InterPro:   IPR011006
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789
- SMART:   SM00448

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat; SSF52172 CheY_like; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 47526; Mature: 47526

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50110 RESPONSE_REGULATORY; PS00675 SIGMA54_INTERACT_1; PS00676 SIGMA54_INTERACT_2; PS00688 SIGMA54_INTERACT_3; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDECSILLIDDDVDVLDAYTQMLEQAGYRVRGFTHPFEAKEWVKADWEGIVLSDVCMP
CCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCEEEHHHHCC
GCSGIDLMTLFHQDDDQLPILLITGHGDVPMAVDAVKKGAWDFLQKPVDPGKLLILIEDA
CCCCCHHHEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHH
LRQRRSVIARRQYCQQTLQVELIGRSEWMNQFRQRLQQLAETDIAVWFYGEHGTGRMTGA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHH
RYLHQLGRNAKGPFVRYELTPENAGQLETFIDQAQGGTLVLSHPEYLTREQQHHLARLQS
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHH
LEHRPFRLVGVGSASLVEQAAANQIAAELYYCFAMTQIACQSLSQRPDDIEPLFRHYLRK
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ACLRLNHPVPEIAGELLKGIMRRAWPSNVRELANAAELFAVGVLPLAETVNPQLLLQEPT
HHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
PLDRRVEEYERQIITEALNIHQGRINEVAEYLQIPRKKLYLRMKKYGLSKEHYKF
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLNDECSILLIDDDVDVLDAYTQMLEQAGYRVRGFTHPFEAKEWVKADWEGIVLSDVCMP
CCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCEEEHHHHCC
GCSGIDLMTLFHQDDDQLPILLITGHGDVPMAVDAVKKGAWDFLQKPVDPGKLLILIEDA
CCCCCHHHEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHH
LRQRRSVIARRQYCQQTLQVELIGRSEWMNQFRQRLQQLAETDIAVWFYGEHGTGRMTGA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHH
RYLHQLGRNAKGPFVRYELTPENAGQLETFIDQAQGGTLVLSHPEYLTREQQHHLARLQS
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHH
LEHRPFRLVGVGSASLVEQAAANQIAAELYYCFAMTQIACQSLSQRPDDIEPLFRHYLRK
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ACLRLNHPVPEIAGELLKGIMRRAWPSNVRELANAAELFAVGVLPLAETVNPQLLLQEPT
HHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
PLDRRVEEYERQIITEALNIHQGRINEVAEYLQIPRKKLYLRMKKYGLSKEHYKF
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3023201; 11677609; 2842311