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The map label for this gene is mdtG [H]

Identifier: 194736766

GI number: 194736766

Start: 448444

End: 449655

Strand: Direct

Name: mdtG [H]

Synonym: SeSA_A0436

Alternate gene names: 194736766

Gene position: 448444-449655 (Clockwise)

Preceding gene: 194737281

Following gene: 194735119

Centisome position: 9.52

GC content: 52.31

Gene sequence:

>1212_bases
ATGGAATCCTGGAAAGTTAATCTAATTTCCGTTTGGTTTGGATGTTTTTTTACCGGGCTGGCAATCAGCCAAATCCTGCC
ATTTTTACCCCTTTATATTTCCCAGCTTGGCGTCTCTTCCCATGAAGCGTTATCAATGTGGTCCGGGTTAACGTTTAGCA
TCACGTTTCTTATTTCCGCCATTGTGTCGCCGATGTGGGGCAGTCTCGCCGATCGTAAAGGGCGTAAACTGATGCTATTG
CGCGCGTCGCTCGGGATGGCGATAGCTATTCTACTGCAGGCATTCGCGACCCATGTCTGGCAACTTTTCCTGCTGCGCGG
AATCATGGGGTTAACGTCAGGCTATATCCCCAATGCCATGGCGCTGGTAGCCTCTCAGGTACCGCGCGAACGTAGCGGCT
GGGCGCTCAGTACGCTTTCTACCGCGCAAATCAGCGGCGTTATCGGCGGGCCGTTAATGGGCGGCTTTGTCGCGGATCAT
ATCGGGCTGCGGGCGGTATTTCTGATTACCGCCATGCTGTTGGTGGTGAGCTTTCTGGTCACGCTATTTTTAATTAAAGA
AGGCGTACGTCCGGTCATCAGGAAAAGCGAACGCCTGAGCGGTAAAGCCGTTTTTGCGTCGTTACCTTATCCTGCGCTGG
TGATCAGTTTGTTTTTTACCACGATGGTCATTCAACTCTGTAATGGTTCCATCAGTCCAATCCTGGCGCTGTTTATCAAA
TCAATGATGCCGGACAGTAATAACATCGCCTTTCTTAGCGGGTTAATTGCCTCGGTGCCCGGTATCTCCGCGCTTATCTC
CGCGCCTCGCCTGGGAAAACTTGGCGACAGAATCGGCACGGAAAGAATTCTGATGGCCACGCTTATCTGCGCAGTGCTGC
TTTTCTTCGCGATGTCCTGGGTCACCACGCCGTTCCAGTTGGGGCTGTTGCGTTTCTTGTTAGGCTTTGCCGATGGCGCG
ATGTTACCCGCCGTACAAACGTTATTGGTGAAATACTCCAGCGATCAAATTACCGGACGTATTTTTGGTTACAACCAGTC
ATTTATGTACCTGGGCAACGTGGTTGGGCCGTTGATGGGCGCGACGGTATCGGCGATGGCCGGTTTCCGCTGGGTTTTTA
TCGCTACGGCGGCGATCGTGTTGATCAATATTGGGCAACTGACCCTGGCGTTACGTCGTCGGCGTAACGCGCAAAAAGCG
AAAGGCCAATAG

Upstream 100 bases:

>100_bases
AAAATAGCAAAGTGTGACGTATCGCACCTCTGGAACCACCAGGAAAATGAGAGCTTGCTAAGCTAACGCGTATTTTCAGC
TACTTACCGTTACGAGTCTT

Downstream 100 bases:

>100_bases
CGGTGCATCGTAACGGCGCTTCTGCCGTTACGATATGGTTTAAATTAAAAGATATATTCTTTATCCGTGAAGTTTTTCTA
TAGATGGCATAACCTTAAAT

Product: major facilitator superfamily MFS_1

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MESWKVNLISVWFGCFFTGLAISQILPFLPLYISQLGVSSHEALSMWSGLTFSITFLISAIVSPMWGSLADRKGRKLMLL
RASLGMAIAILLQAFATHVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLSTAQISGVIGGPLMGGFVADH
IGLRAVFLITAMLLVVSFLVTLFLIKEGVRPVIRKSERLSGKAVFASLPYPALVISLFFTTMVIQLCNGSISPILALFIK
SMMPDSNNIAFLSGLIASVPGISALISAPRLGKLGDRIGTERILMATLICAVLLFFAMSWVTTPFQLGLLRFLLGFADGA
MLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVVGPLMGATVSAMAGFRWVFIATAAIVLINIGQLTLALRRRRNAQKA
KGQ

Sequences:

>Translated_403_residues
MESWKVNLISVWFGCFFTGLAISQILPFLPLYISQLGVSSHEALSMWSGLTFSITFLISAIVSPMWGSLADRKGRKLMLL
RASLGMAIAILLQAFATHVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLSTAQISGVIGGPLMGGFVADH
IGLRAVFLITAMLLVVSFLVTLFLIKEGVRPVIRKSERLSGKAVFASLPYPALVISLFFTTMVIQLCNGSISPILALFIK
SMMPDSNNIAFLSGLIASVPGISALISAPRLGKLGDRIGTERILMATLICAVLLFFAMSWVTTPFQLGLLRFLLGFADGA
MLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVVGPLMGATVSAMAGFRWVFIATAAIVLINIGQLTLALRRRRNAQKA
KGQ
>Mature_403_residues
MESWKVNLISVWFGCFFTGLAISQILPFLPLYISQLGVSSHEALSMWSGLTFSITFLISAIVSPMWGSLADRKGRKLMLL
RASLGMAIAILLQAFATHVWQLFLLRGIMGLTSGYIPNAMALVASQVPRERSGWALSTLSTAQISGVIGGPLMGGFVADH
IGLRAVFLITAMLLVVSFLVTLFLIKEGVRPVIRKSERLSGKAVFASLPYPALVISLFFTTMVIQLCNGSISPILALFIK
SMMPDSNNIAFLSGLIASVPGISALISAPRLGKLGDRIGTERILMATLICAVLLFFAMSWVTTPFQLGLLRFLLGFADGA
MLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVVGPLMGATVSAMAGFRWVFIATAAIVLINIGQLTLALRRRRNAQKA
KGQ

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=396, Percent_Identity=60.1010101010101, Blast_Score=459, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43550; Mature: 43550

Theoretical pI: Translated: 11.28; Mature: 11.28

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESWKVNLISVWFGCFFTGLAISQILPFLPLYISQLGVSSHEALSMWSGLTFSITFLISA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHH
IVSPMWGSLADRKGRKLMLLRASLGMAIAILLQAFATHVWQLFLLRGIMGLTSGYIPNAM
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALVASQVPRERSGWALSTLSTAQISGVIGGPLMGGFVADHIGLRAVFLITAMLLVVSFLV
HHHHHHCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLFLIKEGVRPVIRKSERLSGKAVFASLPYPALVISLFFTTMVIQLCNGSISPILALFIK
HHHHHHHCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SMMPDSNNIAFLSGLIASVPGISALISAPRLGKLGDRIGTERILMATLICAVLLFFAMSW
HHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTTPFQLGLLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVVGPLMG
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHH
ATVSAMAGFRWVFIATAAIVLINIGQLTLALRRRRNAQKAKGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MESWKVNLISVWFGCFFTGLAISQILPFLPLYISQLGVSSHEALSMWSGLTFSITFLISA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHH
IVSPMWGSLADRKGRKLMLLRASLGMAIAILLQAFATHVWQLFLLRGIMGLTSGYIPNAM
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALVASQVPRERSGWALSTLSTAQISGVIGGPLMGGFVADHIGLRAVFLITAMLLVVSFLV
HHHHHHCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLFLIKEGVRPVIRKSERLSGKAVFASLPYPALVISLFFTTMVIQLCNGSISPILALFIK
HHHHHHHCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SMMPDSNNIAFLSGLIASVPGISALISAPRLGKLGDRIGTERILMATLICAVLLFFAMSW
HHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTTPFQLGLLRFLLGFADGAMLPAVQTLLVKYSSDQITGRIFGYNQSFMYLGNVVGPLMG
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHH
ATVSAMAGFRWVFIATAAIVLINIGQLTLALRRRRNAQKAKGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA