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The map label for this gene is emrD [H]

Identifier: 194736656

GI number: 194736656

Start: 3881504

End: 3882664

Strand: Direct

Name: emrD [H]

Synonym: SeSA_A4008

Alternate gene names: 194736656

Gene position: 3881504-3882664 (Clockwise)

Preceding gene: 194737734

Following gene: 194735344

Centisome position: 82.43

GC content: 58.57

Gene sequence:

>1161_bases
TTGTTGTTGATGTTGGTGTTACTGGTGGCCGTAGGGCAGATGGCGCAAACCATTTATATTCCCGCCATCGCCGATATGGC
ACAAGCGCTAAACGTCCGGGAAGGCGCCGTCCAGAGTGTAATGGCTGCTTACCTCCTGACCTACGGCGTCTCGCAACTGT
TTTACGGCCCGCTTTCCGACCGGGTTGGGCGCCGACCGGTAATCCTCGTCGGCATGTCTATTTTTATGGTAGCGACTCTG
ATCGCCATGACCACGCATAGTTTGACGGTGTTGATTGTCGCCAGCGCCATGCAAGGGATGGGAACCGGCGTTGGCGGAGT
AATGGCGAGAACGCTCCCGCGCGATCTGTATGAAGGAACGCAACTTCGTCACGCCAATAGCCTGTTAAATATGGGGATTC
TGGTCAGCCCGCTGTTAGCGCCGCTGATTGGCGGTCTGCTGGACACCCTGTGGAACTGGCGCGCTTGTTACGCTTTCCTG
CTGGTGCTTTGCGCTGGCGTCACCTTCAGCATGGCGCGCTGGATGCCGGAAACCCGCCCCGCCGGCGCGCCGCGCACACG
GCTGATCGCCAGCTATAAAACGCTGTTTGGCAACGGCGCATTTAACTGTTATCTGCTGATGCTAATCGGCGGGCTGGCTG
GCATTGCGGTCTTTGAAGCCTGTTCCGGCGTGCTGATGGGGGCAGTATTAGGTCTCAGCAGTATGGTGGTAAGCATTCTG
TTTATTCTGCCGATTCCGGCGGCGTTCTTCGGCGCCTGGTTTGCCGGACGCCCGAATAAACGCTTCTCAACCCTGATGTG
GCAGTCAGTTATTTGCTGTCTGCTGGCAGGCCTTATGATGTGGATTCCCGGCTGGTTTGGCGTGATGAACGTCTGGACGC
TACTCATCCCCGCTGCGCTGTTTTTCTTCGGCGCCGGGATGTTATTTCCACTGGCCACCAGCGGCGCGATGGAGCCGTTT
CCGTTCCTCGCAGGCACCGCTGGCGCGCTGGTCGGCGGGCTGCAAAATATTGGTTCCGGCGTACTGGCGTGGCTTTCGGC
AATGCTGCCGCAAACCGGTCAGGGCAGCCTGGGACTGTTGATGACCCTTATGGGGTTGCTGATCCTGGCGTGCTGGCTGC
CGCTGGCGTCACGGATATCGCATCAGGGACAGACGGTTTAA

Upstream 100 bases:

>100_bases
TAGATTCCTCTCGCATTTATGGGAATGCGCAGCAAGTTATTCTTATTTTTTCTTTTTTTGAAAAGTAATCAGCGAAATGA
AAAGGCAGAGAAACGTCAAT

Downstream 100 bases:

>100_bases
CGTTCCCCTCGCCCGGCTTTTTGCCGGGCGTTTCACATTCCGGCGCGATCATCGCATTGAGCAGGGACTCTTGCGCCGGA
CGCCACGCTCCTTCTTCGCC

Product: multidrug resistance protein D

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MLLMLVLLVAVGQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATL
IAMTTHSLTVLIVASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFL
LVLCAGVTFSMARWMPETRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSIL
FILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPF
PFLAGTAGALVGGLQNIGSGVLAWLSAMLPQTGQGSLGLLMTLMGLLILACWLPLASRISHQGQTV

Sequences:

>Translated_386_residues
MLLMLVLLVAVGQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATL
IAMTTHSLTVLIVASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFL
LVLCAGVTFSMARWMPETRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSIL
FILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPF
PFLAGTAGALVGGLQNIGSGVLAWLSAMLPQTGQGSLGLLMTLMGLLILACWLPLASRISHQGQTV
>Mature_386_residues
MLLMLVLLVAVGQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATL
IAMTTHSLTVLIVASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFL
LVLCAGVTFSMARWMPETRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSIL
FILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPF
PFLAGTAGALVGGLQNIGSGVLAWLSAMLPQTGQGSLGLLMTLMGLLILACWLPLASRISHQGQTV

Specific function: Multidrug resistance pump that participates in a low energy shock adaptative response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87082312, Length=375, Percent_Identity=92.2666666666667, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI48994889, Length=363, Percent_Identity=25.6198347107438, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788509, Length=354, Percent_Identity=25.1412429378531, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790146, Length=347, Percent_Identity=25.9365994236311, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790794, Length=184, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787065, Length=168, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=170, Percent_Identity=31.1764705882353, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41011; Mature: 41011

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
6.7 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
6.7 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLMLVLLVAVGQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RVGRRPVILVGMSIFMVATLIAMTTHSLTVLIVASAMQGMGTGVGGVMARTLPRDLYEGT
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
QLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPETRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSIL
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAAL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMLPQTGQGSLGLL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
MTLMGLLILACWLPLASRISHQGQTV
HHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLLMLVLLVAVGQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RVGRRPVILVGMSIFMVATLIAMTTHSLTVLIVASAMQGMGTGVGGVMARTLPRDLYEGT
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
QLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPETRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSIL
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAAL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMLPQTGQGSLGLL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
MTLMGLLILACWLPLASRISHQGQTV
HHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8240355; 7686882; 9278503 [H]