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The map label for this gene is aceB [H]

Identifier: 194736609

GI number: 194736609

Start: 4268008

End: 4269612

Strand: Direct

Name: aceB [H]

Synonym: SeSA_A4394

Alternate gene names: 194736609

Gene position: 4268008-4269612 (Clockwise)

Preceding gene: 194737138

Following gene: 194736131

Centisome position: 90.63

GC content: 51.59

Gene sequence:

>1605_bases
ATGATGAATCCACAGGCAACCACAACTGATGAATTAACCTTTACCAGGCCGCAAGGCGAGCTGGAAAAGCAAGTCCTGAC
CGCTGAGGCAGTCGAGTTTTTGACGGAGTTAGTTACCCGTTTTACGCCAAAACGCAATAAACTCCTGGCTGCACGTATCC
AGCAACAGCAGGATATTGATAACGGTAAGTTGCCTGATTTTATTTCGGAAACCACTTCCATTAGAGAAAGTAATTGGCAG
ATTCGTGGTATTCCGGCGGATTTACAGGATCGCCGAGTAGAAATTACCGGGCCGGTTGAACGTAAAATGGTGATTAATGC
CCTGAACGCAAACGTGAAAGTGTTTATGGCGGATTTTGAAGACTCGCTGGCGCCGGACTGGAATAAAGTTATGGATGGTC
AAATCAACCTGCGTGATGCGGTGAACGGCACCATTAGCTATACCAACGAAGCCGGAAAAATCTATCAGCTCAAGCCCGAT
CCGGCCGTATTGATTTGTCGTGTACGTGGTCTACATCTGCCAGAAAAACATGTTACCTGGCGGGGGGAAGCCATTCCCGG
CAGCCTGTTTGATTTTGCTCTGTACTTTTTCCACAACTATAAAGCGCTGCTCGCTAAAGGTAGCGGCCCGTATTTTTACC
TGCCGAAAACGCAAGCCTGGCAGGAAGCAGCCTGGTGGAGTGAAGTTTTCAGCTACGCCGAAGACCGCTTCAATCTACCG
CGCGGTACGATCAAAGCGACCCTGTTGATTGAAACGCTGCCTGCTGTTTTCCAGATGGATGAGATTCTTCATGCGCTGCG
TGATCATATCGTCGGTCTCAACTGTGGTCGCTGGGATTATATTTTCAGCTATATCAAAACGTTGAAAAATTACCCGGATC
GCGTCTTGCCGGACAGGCAGGTGGTAACGATGGACAAACCGTTTCTGAGCGCCTACTCGCGCCTGCTAATCAAAACCTGT
CACAAGCGCGGCGCGTTCGCGATGGGCGGTATGGCGGCGTTTATCCCGAGCAAAGACGTTGAACGCAACAATCAGGTCCT
TGCCAAAGTGAAAGCGGATAAAGCGCTGGAAGCGAACAACGGCCACGACGGCACGTGGATTGCGCATCCCGGGTTGGCGG
ATACCGCAATGGCCGTCTTTAACGAGGTACTGGGCGAGCACAAAAATCAGCTGTTCATTACCCGTGATGAAGATGCGCCG
ATTACCGCTGAACAGTTACTGGAGCCATGTGAAGGCGAACGCACAGAAGCGGGAATGCGCGCCAATATTCGCGTGGCAGT
GCAGTACATTGAAGCGTGGATCTCCGGCAATGGCTGTGTACCGATTTACGGTCTGATGGAGGATGCCGCGACGGCGGAAA
TCTCACGAACCTCTATCTGGCAGTGGATTCACCATGAGAAAACACTGAGCAATGGAAAACCCGTAACGAAAACGCTTTTC
CGCGAAATGTTGGCGGAAGAGATGCGGGTAATCCAGGACGAACTGGGCGAGCACCGCTACAGCAGCGGGCGCTTCGACGA
TGCCGCACGTCTGATGGAGCAAATCACCACCTCAGATGACTTAATCGACTTCCTCACCCTGCCGGGCTATCGCTTACTGG
CTTAA

Upstream 100 bases:

>100_bases
TTGAAATTTAATTGAGTAGTCTTAGTTGTGTTGAACGAAAAGCGCACAGTGATCCTTCGTTCGCATTGGGGATGTATCTG
GATCAACAACGAGGAGCTGC

Downstream 100 bases:

>100_bases
TTCACCACATAACAATATGGAGCATCTGCACATGAAAACCCGTACTCAACAAATCGAAGAATTACAGAAAGAGTGGACAC
AACCGCGCTGGGAAGGCATC

Product: malate synthase

Products: NA

Alternate protein names: MSA [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MMNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDIDNGKLPDFISETTSIRESNWQ
IRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVMDGQINLRDAVNGTISYTNEAGKIYQLKPD
PAVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLP
RGTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQVVTMDKPFLSAYSRLLIKTC
HKRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANNGHDGTWIAHPGLADTAMAVFNEVLGEHKNQLFITRDEDAP
ITAEQLLEPCEGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKTLF
REMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA

Sequences:

>Translated_534_residues
MMNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDIDNGKLPDFISETTSIRESNWQ
IRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVMDGQINLRDAVNGTISYTNEAGKIYQLKPD
PAVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLP
RGTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQVVTMDKPFLSAYSRLLIKTC
HKRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANNGHDGTWIAHPGLADTAMAVFNEVLGEHKNQLFITRDEDAP
ITAEQLLEPCEGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKTLF
REMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA
>Mature_534_residues
MMNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDIDNGKLPDFISETTSIRESNWQ
IRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVMDGQINLRDAVNGTISYTNEAGKIYQLKPD
PAVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLP
RGTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQVVTMDKPFLSAYSRLLIKTC
HKRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANNGHDGTWIAHPGLADTAMAVFNEVLGEHKNQLFITRDEDAP
ITAEQLLEPCEGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKTLF
REMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA

Specific function: Glyoxylate bypass; second step. [C]

COG id: COG2225

COG function: function code C; Malate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790444, Length=533, Percent_Identity=90.8067542213884, Blast_Score=1023, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17561814, Length=528, Percent_Identity=51.1363636363636, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI71982926, Length=422, Percent_Identity=53.7914691943128, Blast_Score=423, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322222, Length=528, Percent_Identity=46.0227272727273, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324212, Length=488, Percent_Identity=47.3360655737705, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011076
- InterPro:   IPR006252
- InterPro:   IPR001465
- InterPro:   IPR019830 [H]

Pfam domain/function: PF01274 Malate_synthase [H]

EC number: =2.3.3.9 [H]

Molecular weight: Translated: 60559; Mature: 60559

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00510 MALATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDID
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
NGKLPDFISETTSIRESNWQIRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFE
CCCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCC
DSLAPDWNKVMDGQINLRDAVNGTISYTNEAGKIYQLKPDPAVLICRVRGLHLPEKHVTW
CCCCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEECCCCCCCHHCCC
RGEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLP
CCCCCCCHHHHHHHHHHHCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
RGTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCE
VVTMDKPFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANN
EEEECCHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCCEEEEEHHCCCEECCC
GHDGTWIAHPGLADTAMAVFNEVLGEHKNQLFITRDEDAPITAEQLLEPCEGERTEAGMR
CCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCCCC
ANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKTLF
CHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
REMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MMNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDID
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
NGKLPDFISETTSIRESNWQIRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFE
CCCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCC
DSLAPDWNKVMDGQINLRDAVNGTISYTNEAGKIYQLKPDPAVLICRVRGLHLPEKHVTW
CCCCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEECCCCCCCHHCCC
RGEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLP
CCCCCCCHHHHHHHHHHHCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
RGTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCE
VVTMDKPFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANN
EEEECCHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCCEEEEEHHCCCEECCC
GHDGTWIAHPGLADTAMAVFNEVLGEHKNQLFITRDEDAPITAEQLLEPCEGERTEAGMR
CCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCCCC
ANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKTLF
CHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
REMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3050899; 3060852; 8265357; 9278503 [H]