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The map label for this gene is pdxB [H]

Identifier: 194736566

GI number: 194736566

Start: 2485453

End: 2486589

Strand: Reverse

Name: pdxB [H]

Synonym: SeSA_A2600

Alternate gene names: 194736566

Gene position: 2486589-2485453 (Counterclockwise)

Preceding gene: 194735953

Following gene: 194737107

Centisome position: 52.8

GC content: 56.46

Gene sequence:

>1137_bases
GTGAAAATTCTCGTTGATGAAAATATGCCTTACGCCCGCGAATTATTTAGCCGCCTGGGTGAGGTAAAGGCAGTGCCGGG
TCGCCCGATCCCCGTTGAAGAATTGAACCATGCCGATGCGTTAATGGTGCGTTCGGTCACGAAAGTGAATGAATCGCTGC
TGAGCGGCACGCCGATTAACTTCGTTGGTACTGCTACGGCAGGCACCGATCATGTGGATGAGGCATGGCTGAAGCAGGCG
GGCATCGGTTTTTCAGCCGCGCCCGGCTGTAATGCTATCGCCGTGGTGGAGTATGTGTTTTCCGCGCTGTTGATGCTGGC
CGAACGTGACGGCTTTTCGTTACGCGATCGCACTATAGGGATTGTCGGCGTGGGTAACGTCGGAAGCCGGCTACAGACCA
GGCTTGAAGCGTTGGGTATCCGCACGTTGCTGTGCGATCCGCCACGCGCCGCACGCGGGGACGAGGGTGATTTTCGTACG
CTGGATGAGCTGGTGCAGGAAGCGGATGTCCTGACTTTCCATACGCCGCTTTATAAAGACGGACCGTACAAAACGCTGCA
TCTGGCCGATGAGACGCTGATCCGTCGACTGAAACCCGGCGCCATTCTCATTAACGCCTGCCGCGGTCCGGTGGTGGATA
ACGCCGCGTTGTTGGCGCGACTTAATGCCGGGCAGCCGCTGAGCGTGGTGCTTGATGTGTGGGAGGGCGAACCGGATCTT
AACGTCGCGCTACTGGAAGCCGTGGATATCGGCACGTCGCATATTGCCGGCTATACGCTGGAAGGCAAAGCGCGCGGCAC
CACCCAGGTCTTTGAGGCGTATAGCGCGTTTATCGGTCGCGAGCAGCATGTCGCGCTGGAGACATTACTGCCTGCGCCTG
AGTTTGGTCGTATTACGCTTCACGGCCCGCTGGATCAACCGACGCTGAAAAGACTGGCGCATTTGGTGTATGATGTGCGC
CGCGACGATGCGCCACTGCGTAAAGTCGCTGGAATTCCGGGTGAATTTGATAAATTGCGTAAAAATTATCTTGAGCGCCG
TGAATGGTCGTCTTTATACGTGATGTGTGACGACGAAACGGCAGCCGCCTTGCTGTGTAAGCTAGGTTTTAACGCTGTTC
ATCACCCGGCACATTAA

Upstream 100 bases:

>100_bases
TAATTATCCTTTAACCATAAATCTGAGCAATATATGCCTGGCGGCCAGATTATGGCACACTTGTCCGGTTAACTCTCGTT
CTCAAACAGGTACGACAGTC

Downstream 100 bases:

>100_bases
TGTCTTCTTAATGCTCCCTGTCGAATAATGCGACAGGGACGCTTATGTATTTCTGGAGTAAATCACCATGTCTGAAGGCT
GGAACATTGCCATTCTGGGC

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQA
GIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRT
LDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDL
NVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQHVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVR
RDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH

Sequences:

>Translated_378_residues
MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQA
GIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRT
LDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDL
NVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQHVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVR
RDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH
>Mature_378_residues
MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQA
GIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRT
LDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDL
NVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQHVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVR
RDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=29.1095890410959, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4557497, Length=228, Percent_Identity=24.5614035087719, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI61743967, Length=234, Percent_Identity=25.2136752136752, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI145580578, Length=283, Percent_Identity=25.4416961130742, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4557499, Length=283, Percent_Identity=25.4416961130742, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788660, Length=377, Percent_Identity=89.3899204244032, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1787645, Length=202, Percent_Identity=27.2277227722772, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789279, Length=257, Percent_Identity=29.1828793774319, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082289, Length=159, Percent_Identity=33.9622641509434, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=256, Percent_Identity=27.34375, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=323, Percent_Identity=28.1733746130031, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=323, Percent_Identity=28.7925696594427, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=25.8181818181818, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=174, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921140, Length=297, Percent_Identity=27.6094276094276, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646446, Length=234, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646448, Length=234, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646452, Length=234, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646450, Length=234, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI62472511, Length=234, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574286, Length=239, Percent_Identity=26.7782426778243, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45552429, Length=247, Percent_Identity=25.5060728744939, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574284, Length=247, Percent_Identity=25.5060728744939, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585514, Length=247, Percent_Identity=25.5060728744939, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574282, Length=247, Percent_Identity=25.5060728744939, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551003, Length=247, Percent_Identity=25.5060728744939, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 41280; Mature: 41280

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPIN
CEEEECCCCCHHHHHHHHHCCEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
FVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIG
EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
IVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKD
EEEECCCHHHHHHHHHHHCCHHEEECCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCC
GPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDL
CCCCEEEECHHHHHHHCCCCEEEEECCCCCCCCCHHHHEECCCCCCCEEEEEEECCCCCC
NVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQHVALETLLPAPEFGRITL
CEEEEEEHHCCCHHHCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEE
HGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDET
ECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCH
AAALLCKLGFNAVHHPAH
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPIN
CEEEECCCCCHHHHHHHHHCCEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
FVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIG
EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
IVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKD
EEEECCCHHHHHHHHHHHCCHHEEECCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCC
GPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDL
CCCCEEEECHHHHHHHCCCCEEEEECCCCCCCCCHHHHEECCCCCCCEEEEEEECCCCCC
NVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQHVALETLLPAPEFGRITL
CEEEEEEHHCCCHHHCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEE
HGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDET
ECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCH
AAALLCKLGFNAVHHPAH
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA