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The map label for this gene is hycC [H]

Identifier: 194736463

GI number: 194736463

Start: 2903741

End: 2905567

Strand: Reverse

Name: hycC [H]

Synonym: SeSA_A3003

Alternate gene names: 194736463

Gene position: 2905567-2903741 (Counterclockwise)

Preceding gene: 194735766

Following gene: 194736897

Centisome position: 61.7

GC content: 61.41

Gene sequence:

>1827_bases
ATGAGTTCACTTTCACTGATTACTAGCGGCGTCGCGTGGTTTGCCGCCGCCGCCGTTCTGGCGTTTCTGTTTTCGTTTCA
TAAAGCGCTGAGCGGCTGGATTGCCGGTATCGGCGGCGCGGTCGGCAGCCTGTGTACGGCTGGCGCGGGGTTCACCGCGC
TGACCAGCGCCGTTACGGTGAGCGGCGTGATGCCGTTTACCGGTCACATGCTGCAAATTACGCCGCTGAATGCTATCTGG
CTGATTACGCTGGGGCTGTGCGGTCTGTTCGTCAGCCTGTTCAATATCGACTGGCATCGCCATCCACAGGTAAAAGCCAA
CGGGCTGTTAATCAACCTGCTAATGGCGGCAGCCGTCTGCGCCGTGGTCGCCAGTAATCTGGGGACGATGGTGGTGATGG
CGGAAATCATGGCGCTCTGCGCCGTGTTCCTCACCGGCGGTAGCAAAGAGGGCAAACTGTGGTTTGCGCTGGGCCGTCTC
GGTACGCTGCTGCTGGCAATCGCCTGCTGGCTGGTGTGGCAGCGCTACGGCACGCTGGATCTGGGGCTGCTGGATCAACG
CGCTCAGCAACTGCCGCTGGGCTCCGATATCTGGCTGCTCGGCGTTATCGGTTTTGGTCTGCTGGCCGGGATTATCCCGC
TACACGGTTGGGTGCCGCAGGCGCACGCCAACGCCAGCGCTCCCGCCGCCGCGCTGTTCTCGACCGTGGTGATGAAAATC
GGGCTGCTGGGCATTCTCACGCTATCTCTGCTTGGCGGCAATGCGCCGCTGTGGTGGGGCGTGGCGCTGTTGGTGCTTGG
GATGATCACCGCCTTTGTCGGCGGTCTGTACGCGCTGATGGAGCATAACATTCAGCGCCTGCTGGCCTATCACACGCTGG
AAAATATCGGCATCATTTTGCTCGGGCTGGGCGCAGGCGTTACCGGGATTGCTCTCAATCAGCCGGTACTGATCGCGCTG
GGTCTGACCGGCGGGCTCTATCACCTGCTGAACCATAGCCTGTTTAAAAGCGTGCTGTTTCTGGGCGCGGGCAGCATCTG
GTTCCGTACCGGTCATCGCGATATCGAAAAACTGGGCGGTATTGGTAAACGGATGCCGGTTATTTCTATCGCCATGCTGG
TCGGTCTGATGGCGATGGCCGCGCTGCCGCCGCTGAACGGCTTTGCCGGCGAGTGGGTGATTTACCAGTCCTTCTTCAAA
CTGGGCAACAGCGGCGCGTTTGTTGGTCGTCTGTTAGGACCGCTGCTGGCGGTTGGCCTGGCGATTACCGGCGCGCTGGC
GGTGATGTGTATGGCGAAAGTTTACGGCGTGACGTTCCTTGGCGCGCCGCGCACGAAGGAAGCTGAAAACGCCAGCTGCG
CGCCGATCCTGATGGGCGTCAGCGTGGTGGCATTGGCGATTTGCTGCGTACTGGGCGGGGTTGCCGCGCCGTGGCTGCTG
CCGATGATTTCCACTGCGGTACCGTTGCCGCTGGAAACCGCGCACACCACCGTATCGCAGCCGATGATCACGCTGCTGTT
GGTCGCCTGTCCGCTACTGCCGTTCATCATTATGGCGATGTTCAAAGGCAACCGTCTGCCGTCGCGTTCTCGCGGCGCGG
CCTGGGTGTGCGGCTACGACCATGAGCAGTCGATGGTGATTACCGCGCACGGTTTCGCCATGCCGGTGAAAGAGGCCTTT
GCCCCGGTACTTAAACTGCGTAAATGGCTGAACCCGGTATCGCTGGTGCCGGGCTGGCAGAACGCGGCGGCCGCGGTGCT
ATTCCGTCGTCTGGCGCTGATTGAGCTGGCGGTGCTGGTGGTGATTGTGGTTTCACGAGGAGCCTGA

Upstream 100 bases:

>100_bases
CGGATATCGCCCGCGCCAGCAAACGTAAACGTGAGCTGACGTTTAATACCGATTTTGGCGATCTCACCTTGTTTCAGCAG
GCTCAGAGTGGGGATGCATA

Downstream 100 bases:

>100_bases
AAATGAGTGTGTTTTATCCGTTAATTCAGGCGCTGGTGCTATTTGCCGTTGCGCCATTGCTGTCCGGTATTACTCGCGTG
GCACGCGCCCGTCTACACAA

Product: formate hydrogenlyase subunit 3

Products: NA

Alternate protein names: FHL subunit 3; Hydrogenase-3 component C [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTVSGVMPFTGHMLQITPLNAIW
LITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVCAVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRL
GTLLLAIACWLVWQRYGTLDLGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKI
GLLGILTLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGAGVTGIALNQPVLIAL
GLTGGLYHLLNHSLFKSVLFLGAGSIWFRTGHRDIEKLGGIGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFK
LGNSGAFVGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAICCVLGGVAAPWLL
PMISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYDHEQSMVITAHGFAMPVKEAF
APVLKLRKWLNPVSLVPGWQNAAAAVLFRRLALIELAVLVVIVVSRGA

Sequences:

>Translated_608_residues
MSSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTVSGVMPFTGHMLQITPLNAIW
LITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVCAVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRL
GTLLLAIACWLVWQRYGTLDLGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKI
GLLGILTLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGAGVTGIALNQPVLIAL
GLTGGLYHLLNHSLFKSVLFLGAGSIWFRTGHRDIEKLGGIGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFK
LGNSGAFVGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAICCVLGGVAAPWLL
PMISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYDHEQSMVITAHGFAMPVKEAF
APVLKLRKWLNPVSLVPGWQNAAAAVLFRRLALIELAVLVVIVVSRGA
>Mature_607_residues
SSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTVSGVMPFTGHMLQITPLNAIWL
ITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVCAVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRLG
TLLLAIACWLVWQRYGTLDLGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIG
LLGILTLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGAGVTGIALNQPVLIALG
LTGGLYHLLNHSLFKSVLFLGAGSIWFRTGHRDIEKLGGIGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKL
GNSGAFVGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAICCVLGGVAAPWLLP
MISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYDHEQSMVITAHGFAMPVKEAFA
PVLKLRKWLNPVSLVPGWQNAAAAVLFRRLALIELAVLVVIVVSRGA

Specific function: Hydrogen metabolism; FHL pathway. [C]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=179, Percent_Identity=30.7262569832402, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI2367154, Length=608, Percent_Identity=89.3092105263158, Blast_Score=1021, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=534, Percent_Identity=39.1385767790262, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1788831, Length=356, Percent_Identity=29.2134831460674, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788614, Length=289, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788829, Length=190, Percent_Identity=27.3684210526316, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788613, Length=193, Percent_Identity=27.4611398963731, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: NA

Molecular weight: Translated: 63747; Mature: 63615

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SGVMPFTGHMLQITPLNAIWLITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVC
HCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRLGTLLLAIACWLVWQRYGTLD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCC
LGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GLLGILTLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIIL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LGLGAGVTGIALNQPVLIALGLTGGLYHLLNHSLFKSVLFLGAGSIWFRTGHRDIEKLGG
EECCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHCC
IGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLGNSGAFVGRLLGPLLAVGL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAICCVLGGVAAPWLL
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
HEQSMVITAHGFAMPVKEAFAPVLKLRKWLNPVSLVPGWQNAAAAVLFRRLALIELAVLV
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VIVVSRGA
HHHHCCCC
>Mature Secondary Structure 
SSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SGVMPFTGHMLQITPLNAIWLITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVC
HCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRLGTLLLAIACWLVWQRYGTLD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCC
LGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GLLGILTLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIIL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LGLGAGVTGIALNQPVLIALGLTGGLYHLLNHSLFKSVLFLGAGSIWFRTGHRDIEKLGG
EECCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHCC
IGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLGNSGAFVGRLLGPLLAVGL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAICCVLGGVAAPWLL
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
HEQSMVITAHGFAMPVKEAFAPVLKLRKWLNPVSLVPGWQNAAAAVLFRRLALIELAVLV
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VIVVSRGA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2187144; 9278503 [H]