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The map label for this gene is mltC [H]

Identifier: 194736451

GI number: 194736451

Start: 3170147

End: 3171232

Strand: Direct

Name: mltC [H]

Synonym: SeSA_A3286

Alternate gene names: 194736451

Gene position: 3170147-3171232 (Clockwise)

Preceding gene: 194734289

Following gene: 194737622

Centisome position: 67.32

GC content: 52.12

Gene sequence:

>1086_bases
ATGATGAAAAAATTACTCGCGCTTGCTGTTATTGCGCCGTTGCTCATCTCCTGCTCCAGTTCGACCAAAAAAGGCGAGAC
GTATAATGAAGCCTGGGTCAAGGATACCAACGGCTTTGATATTTTGATGGGGCAATTTGCCAACAATATTGAAAATCTGT
GGGGATATAAGGAAGTCCTGATCGCCGGGCCGAAAGACTACGTCAAATATACCGATCAGTTCCAGACCCGTAGCCACATC
AACTTTGATGATGGGACCATTACCGTTGAAACCATCGCCGGGACGGAACCTACCGCACATCTGCGCCGGGCCATTATTAA
AACGTTGCTCATGGGTGACGACCCAACCTCCGTCGATCTTTACTCCGATGTCGATGACATAAAAATTTCTAAAGAACCCT
TCCTGTATGGTCAGGTCCTCGACAATACCGGCCAGCCTATTCGCTGGGAAGGCCGCGCCACGACATTCGCGGATTACTTG
CTGAAAACGCGGCTCAAAAGCCGCAGTAACGGCCTGCGTATTATTTACAGCGTCACCATTAATCTGGTGCCGAACCACCT
TGATAAACGCGCGCATAAATACATTGGCATGGTACGCCAGGCCTCCCGTAAATACGGCGTTGACGAGTCGCTGATTCTGG
CGATTATGCAAACGGAGTCCTCGTTCAACCCGTATGCGGTCAGCCACGCGGATGCGCTGGGCCTGATGCAGGTGGTGCAA
CACAGCGCCGGGAAAGATGTTTTCCGTTCTCAGGGTAAGTCCGGCACGCCAAGCCGTAACTTCCTGTTCGACCCCGCCAG
CAATATCGATACCGGCACAGCGTATCTGGCGATGTTGAATAATGTCTATCTGAGCGGTATTGAGAATCCGACGTCGCGGC
GCTATGCGGTCATTACCGCCTACAATGGCGGCGCAGGCAGCGTATTACGCGTATTCTCGAACGATAAAATTCAGGCCGCG
AATATGATTAACCGCATGTCGCCGGGGGATGTGTACCAGATATTAACCACCCGACATCCATCTGCGGAGTCGCGCCGCTA
TCTGTATAAGGTGAATTCCGCCCAGCGATCGTATCGCCGCCGATAA

Upstream 100 bases:

>100_bases
ATGAGGCTGCGCTTATTCGGCCTGTGAGTTATGCCGGATAAGCTCTTAGCGCCGCTGCCCGGCAACATGGCATAACGACA
ACACAACATGCACTCCCGGA

Downstream 100 bases:

>100_bases
ACCATCGCATCCCGCCTCTGGCTGGCACAGGACAGCGGCGGGAAAGGCAAAAGTGTTAACTCCGTCACCATTTTACCTTG
CAATCAGAAATTGTTTGCAA

Product: murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MMKKLLALAVIAPLLISCSSSTKKGETYNEAWVKDTNGFDILMGQFANNIENLWGYKEVLIAGPKDYVKYTDQFQTRSHI
NFDDGTITVETIAGTEPTAHLRRAIIKTLLMGDDPTSVDLYSDVDDIKISKEPFLYGQVLDNTGQPIRWEGRATTFADYL
LKTRLKSRSNGLRIIYSVTINLVPNHLDKRAHKYIGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQ
HSAGKDVFRSQGKSGTPSRNFLFDPASNIDTGTAYLAMLNNVYLSGIENPTSRRYAVITAYNGGAGSVLRVFSNDKIQAA
NMINRMSPGDVYQILTTRHPSAESRRYLYKVNSAQRSYRRR

Sequences:

>Translated_361_residues
MMKKLLALAVIAPLLISCSSSTKKGETYNEAWVKDTNGFDILMGQFANNIENLWGYKEVLIAGPKDYVKYTDQFQTRSHI
NFDDGTITVETIAGTEPTAHLRRAIIKTLLMGDDPTSVDLYSDVDDIKISKEPFLYGQVLDNTGQPIRWEGRATTFADYL
LKTRLKSRSNGLRIIYSVTINLVPNHLDKRAHKYIGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQ
HSAGKDVFRSQGKSGTPSRNFLFDPASNIDTGTAYLAMLNNVYLSGIENPTSRRYAVITAYNGGAGSVLRVFSNDKIQAA
NMINRMSPGDVYQILTTRHPSAESRRYLYKVNSAQRSYRRR
>Mature_361_residues
MMKKLLALAVIAPLLISCSSSTKKGETYNEAWVKDTNGFDILMGQFANNIENLWGYKEVLIAGPKDYVKYTDQFQTRSHI
NFDDGTITVETIAGTEPTAHLRRAIIKTLLMGDDPTSVDLYSDVDDIKISKEPFLYGQVLDNTGQPIRWEGRATTFADYL
LKTRLKSRSNGLRIIYSVTINLVPNHLDKRAHKYIGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQ
HSAGKDVFRSQGKSGTPSRNFLFDPASNIDTGTAYLAMLNNVYLSGIENPTSRRYAVITAYNGGAGSVLRVFSNDKIQAA
NMINRMSPGDVYQILTTRHPSAESRRYLYKVNSAQRSYRRR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=360, Percent_Identity=91.1111111111111, Blast_Score=668, Evalue=0.0,
Organism=Escherichia coli, GI87081855, Length=166, Percent_Identity=39.1566265060241, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40406; Mature: 40406

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKLLALAVIAPLLISCSSSTKKGETYNEAWVKDTNGFDILMGQFANNIENLWGYKEVL
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHHCCHHHEE
IAGPKDYVKYTDQFQTRSHINFDDGTITVETIAGTEPTAHLRRAIIKTLLMGDDPTSVDL
EECCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
YSDVDDIKISKEPFLYGQVLDNTGQPIRWEGRATTFADYLLKTRLKSRSNGLRIIYSVTI
CCCCCCCEECCCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEEE
NLVPNHLDKRAHKYIGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQ
EECCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCEEECHHHHHHHHHHHH
HSAGKDVFRSQGKSGTPSRNFLFDPASNIDTGTAYLAMLNNVYLSGIENPTSRRYAVITA
HCCCHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
YNGGAGSVLRVFSNDKIQAANMINRMSPGDVYQILTTRHPSAESRRYLYKVNSAQRSYRR
ECCCCCCEEEEECCCCCHHHHHHHCCCCCHHEEHHHCCCCCCCCCEEEEEECHHHHHHCC
R
C
>Mature Secondary Structure
MMKKLLALAVIAPLLISCSSSTKKGETYNEAWVKDTNGFDILMGQFANNIENLWGYKEVL
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHHCCHHHEE
IAGPKDYVKYTDQFQTRSHINFDDGTITVETIAGTEPTAHLRRAIIKTLLMGDDPTSVDL
EECCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
YSDVDDIKISKEPFLYGQVLDNTGQPIRWEGRATTFADYLLKTRLKSRSNGLRIIYSVTI
CCCCCCCEECCCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEEE
NLVPNHLDKRAHKYIGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQ
EECCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCEEECHHHHHHHHHHHH
HSAGKDVFRSQGKSGTPSRNFLFDPASNIDTGTAYLAMLNNVYLSGIENPTSRRYAVITA
HCCCHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
YNGGAGSVLRVFSNDKIQAANMINRMSPGDVYQILTTRHPSAESRRYLYKVNSAQRSYRR
ECCCCCCEEEEECCCCCHHHHHHHCCCCCHHEEHHHCCCCCCCCCEEEEEECHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA