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The map label for this gene is xapR [H]

Identifier: 194736343

GI number: 194736343

Start: 2535230

End: 2536114

Strand: Reverse

Name: xapR [H]

Synonym: SeSA_A2654

Alternate gene names: 194736343

Gene position: 2536114-2535230 (Counterclockwise)

Preceding gene: 194736044

Following gene: 194736951

Centisome position: 53.86

GC content: 50.96

Gene sequence:

>885_bases
ATGGAACGAGCCCATCGTATTGATCTAAAGCTATTACGTTATTTCCTCGCTGTTGCAGAAGAATTGCATTTTGGCCGGGC
TGCTGCCCGGTTAAATATGTCACAACCTCCCTTGAGTATCCATATCAAAGAACTTGAACAGCAACTGGGTACATTGTTGT
TTATTCGTCATTCCCGCAGCGTTGCATTAACCCATGCCGGGAAAGTTTTAATGGAGGAGTCACGTCGCTTGTTAGCCAAT
GCAAATCAGGCGCTGGCGCGAGTGGAGCAGATTGGTCGCGGTGAAGCGGGGCGCATTGAACTGGGTGTGGTTGGTACGGC
GCTGTGGGGAAGAATGCGCCCTGCGATGCGTCACTTTTTGAAAGCAAACCCCAATGTTGAAGTACTTTTTCGCGAAAAGT
CTCCAGGTATGCAAATGGCGTTGTTAGAGCGTCGGGAGCTTGATGCAGGGATCTGGCGTATGGCTATCGAACCGGCAGTC
GGTTTTACCAGCATACGTTTGCATGAATCTGCATTCATGGTTGCAGTTCCGGAAGATCACGATCTGGCATCCAGAGATTC
TGTGCCGCTGGCGGCGTTGCGCAATGAATATTTTGTCACGCTGCCTTCCGTGCATTCTGATTGGGGATTTTTACAACGTG
TATGCCAACAGGCGGGTTTCTCGCCAATGATTATTCGGGAAGTGGTTGAGCCGCAAACGGTGTTGGCGATGATCAGTATG
GGGATTGGGATTACGTTGATGGCTGATGGCTATGCGCAAATGAGCTGGCCGGGTGTGGTGTTCCGTCCGTTAGAGGAACG
TATTCCGGCGGATTTGTATATTGTGTATGACCAGCAGCAGGCAACGCCAGCACTGGAGAAACTGGTGGCGGCGTTGACGG
TATGA

Upstream 100 bases:

>100_bases
TGTATTTATGTATATTGGGTATCTTGTCGTTAAATCTATTTTTTACTAGGTAATATGGTAAATTCCAGACGTTATCCCTT
ATTGCTGGAGTGCGATAGTG

Downstream 100 bases:

>100_bases
TGTCTGCGCCGGATGGCGACTAACGTCTTATCCGGCCTACGTGTGCGGTGTCGTCTGCGCCGGATGGCGACTAACGTCTT
ATCCGGCCTACGTGTGCGTT

Product: DNA-binding transcriptional activator XapR

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRSVALTHAGKVLMEESRRLLAN
ANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFLKANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAV
GFTSIRLHESAFMVAVPEDHDLASRDSVPLAALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV

Sequences:

>Translated_294_residues
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRSVALTHAGKVLMEESRRLLAN
ANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFLKANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAV
GFTSIRLHESAFMVAVPEDHDLASRDSVPLAALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV
>Mature_294_residues
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRSVALTHAGKVLMEESRRLLAN
ANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFLKANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAV
GFTSIRLHESAFMVAVPEDHDLASRDSVPLAALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=293, Percent_Identity=81.2286689419795, Blast_Score=503, Evalue=1e-144,
Organism=Escherichia coli, GI1787879, Length=284, Percent_Identity=36.2676056338028, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=29.3103448275862, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790399, Length=244, Percent_Identity=29.9180327868852, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=31.0043668122271, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI145693105, Length=242, Percent_Identity=28.9256198347107, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788748, Length=241, Percent_Identity=26.9709543568465, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787589, Length=177, Percent_Identity=34.4632768361582, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790208, Length=250, Percent_Identity=26.4, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790262, Length=288, Percent_Identity=24.6527777777778, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788297, Length=256, Percent_Identity=26.953125, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081904, Length=155, Percent_Identity=33.5483870967742, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787601, Length=302, Percent_Identity=25.1655629139073, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI48994962, Length=87, Percent_Identity=39.0804597701149, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32967; Mature: 32967

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCEEEEECCCC
VALTHAGKVLMEESRRLLANANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
KANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAVGFTSIRLHESAFMVAVPEDH
HCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEEECCEEEEECCCCC
DLASRDSVPLAALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
CCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHH
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV
CCCEEEEECCCCCCCCCCCEECCHHHHCCCEEEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCEEEEECCCC
VALTHAGKVLMEESRRLLANANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
KANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAVGFTSIRLHESAFMVAVPEDH
HCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEEECCEEEEECCCCC
DLASRDSVPLAALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
CCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHH
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV
CCCEEEEECCCCCCCCCCCEECCHHHHCCCEEEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]