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The map label for this gene is menB [H]

Identifier: 194736334

GI number: 194736334

Start: 2419901

End: 2420758

Strand: Reverse

Name: menB [H]

Synonym: SeSA_A2535

Alternate gene names: 194736334

Gene position: 2420758-2419901 (Counterclockwise)

Preceding gene: 194737755

Following gene: 194734201

Centisome position: 51.41

GC content: 56.41

Gene sequence:

>858_bases
ATGATCTATCCTGATGAAACAATGCTTTACGCACCGGTAGAATGGCACGACTGCTCGGAGGGTTACACCGACATTCGTTA
TGAAAAATCCACCGACGGTATTGCAAAAATCACTATTAATCGTCCGCAGGTGCGCAATGCATTTCGTCCGTTGACCGTCA
AAGAGATGATTCAGGCGCTGGCGGATGCCCGTTACGACGACAACGTGGGCGTGATTATTCTGACCGGCGAAGGCGATAAA
GCGTTTTGCGCGGGCGGCGACCAGAAGGTGCGCGGCGATTACGGCGGTTATCAGGATGACTCCGGCGTGCATCACCTGAA
CGTGCTGGATTTCCAGCGCCAGATTCGCACCTGTCCAAAACCGGTTGTCGCGATGGTCGCGGGGTATTCCATCGGCGGTG
GTCATGTGCTGCACATGATGTGCGACCTGACCATCGCGGCGGAAAACGCCATCTTCGGCCAGACCGGTCCGAAAGTCGGC
TCCTTTGACGGCGGCTGGGGCGCTTCATATATGGCGCGTATCGTTGGTCAGAAGAAAGCGCGTGAAATCTGGTTCCTGTG
CCGCCAGTACGATGCGCAACAGGCGCTGGATATGGGCCTGGTCAACACCGTGGTTCCGCTGGCGGATCTGGAAAAAGAGA
CCGTGCGCTGGTGCCGCGAAATGTTGCAAAACAGTCCGATGGCGCTGCGTTGCCTGAAAGCGGCGCTGAATGCCGATTGT
GACGGTCAGGCGGGTCTACAGGAGCTGGCGGGCAACGCTACCATGCTGTTCTACATGACCGAAGAAGGGCAGGAAGGCCG
TAACGCCTTTAACCAGAAGCGTCAGCCTGACTTCAGCAAATTCAAACGGAACCCATAA

Upstream 100 bases:

>100_bases
ATGTTATTCGTAACGCCGGACACAACGCGCATCGGGAAAACCCCGCTGGCGTGGTAGACAGTCTGGCTCAGATTCTGCGT
CTCTGACTAAAGGACACACT

Downstream 100 bases:

>100_bases
TGCGTAGCGCGCAGGTATACCGCTGGCAGATCCCCATGGACGCGGGGGTGGTTCTGCGCGACAGGCGGTTAAAAACTCGC
GACGGGCTGTATGTTTGTCT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MIYPDETMLYAPVEWHDCSEGYTDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNVGVIILTGEGDK
AFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP

Sequences:

>Translated_285_residues
MIYPDETMLYAPVEWHDCSEGYTDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNVGVIILTGEGDK
AFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP
>Mature_285_residues
MIYPDETMLYAPVEWHDCSEGYTDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNVGVIILTGEGDK
AFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=256, Percent_Identity=34.765625, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=30.952380952381, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=28.7081339712919, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=28.7081339712919, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4502327, Length=259, Percent_Identity=28.957528957529, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=28.7081339712919, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI157694516, Length=225, Percent_Identity=24, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=24, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI70995211, Length=239, Percent_Identity=27.6150627615063, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI37594469, Length=142, Percent_Identity=29.5774647887324, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI37594471, Length=142, Percent_Identity=29.5774647887324, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4757966, Length=235, Percent_Identity=25.1063829787234, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI51538581, Length=235, Percent_Identity=25.1063829787234, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI25453481, Length=235, Percent_Identity=25.1063829787234, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI51538573, Length=235, Percent_Identity=25.1063829787234, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4757968, Length=222, Percent_Identity=27.027027027027, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI49355787, Length=222, Percent_Identity=27.027027027027, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=285, Percent_Identity=96.8421052631579, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=32.7935222672065, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082183, Length=257, Percent_Identity=28.0155642023346, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI221142681, Length=200, Percent_Identity=31.5, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787660, Length=257, Percent_Identity=29.1828793774319, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=32.156862745098, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=259, Percent_Identity=31.6602316602317, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=231, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=271, Percent_Identity=27.3062730627306, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=215, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=197, Percent_Identity=24.8730964467005, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=190, Percent_Identity=29.4736842105263, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129971, Length=263, Percent_Identity=33.0798479087452, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653477, Length=263, Percent_Identity=33.0798479087452, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653139, Length=278, Percent_Identity=27.3381294964029, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357171, Length=261, Percent_Identity=28.735632183908, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24654903, Length=203, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922422, Length=202, Percent_Identity=27.2277227722772, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650670, Length=178, Percent_Identity=30.8988764044944, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31693; Mature: 31693

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYPDETMLYAPVEWHDCSEGYTDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQAL
CCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHHCCCCCHHHHHHHH
ADARYDDNVGVIILTGEGDKAFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCEEEEEECCCCEEEECCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHCCCCCCHHHHHHHHHHHEEECCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MIYPDETMLYAPVEWHDCSEGYTDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQAL
CCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHHCCCCCHHHHHHHH
ADARYDDNVGVIILTGEGDKAFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCEEEEEECCCCEEEECCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHCCCCCCHHHHHHHHHHHEEECCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]