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The map label for this gene is hmp [H]

Identifier: 194736279

GI number: 194736279

Start: 2696365

End: 2697555

Strand: Direct

Name: hmp [H]

Synonym: SeSA_A2798

Alternate gene names: 194736279

Gene position: 2696365-2697555 (Clockwise)

Preceding gene: 194737861

Following gene: 194735558

Centisome position: 57.26

GC content: 56.17

Gene sequence:

>1191_bases
ATGCTTGACGCACAAACCATCGCTACAGTAAAGGCCACCATTCCCCTGCTGGTTGAAACAGGACCGAAACTGACCGCCCA
CTTCTACGACCGTATGTTTACGCATAATCCGGAGCTCAAAGAAATCTTCAATATGAGCAACCAGCGTAACGGCGATCAGC
GCGAAGCCCTGTTTAATGCTATCGCGGCCTACGCCAGCAATATCGAAAATTTACCGGCGTTGCTGCCGGCGGTAGAAAAA
ATCGCGCAGAAGCACACCAGCTTCCAGATTAAGCCGGAGCAGTACAACATCGTCGGGACGCATCTGCTGGCGACGCTGGA
CGAAATGTTCAACCCGGGCCAGGAAGTGCTGGACGCGTGGGGCAAAGCCTATGGCGTACTGGCTAACGTCTTTATTCATC
GGGAAGCCGAGATTTATCACGAGAACGCCAGCAAAGACGGCGGCTGGGAAGGCACGCGCCCCTTCCGCATCGTTGCGAAA
ACCCCGCGTAGCGCACTGATCACCAGCTTTGAGTTTGAACCGGTCGACGGCGGTACGGTGGCGGAATACCGTCCCGGGCA
GTATCTGGGCGTCTGGCTGAAGCCGGAAGGTTTTGCACATCAGGAGATCCGCCAATATTCACTGACCCGTAAACCCGATG
GCAAAGGGTACCGTATTGCCGTGAAGCGTGAAGACGGCGGCCAGGTATCAAACTGGTTACACCATCACGCCAGCGTAGGC
GATGTGGTGCGTCTGGCTGCGCCGGCAGGTGACTTCTTTATGAATGTCGCCGCTGATACCCCCGTTTCGCTGATTTCCGC
TGGCGTCGGCCAGACGCCGATGTTAGCGATGCTCGATACGCTGGCGAAAGGACAGCATACCGCGCAGGTGAACTGGTTCC
ACGCGGCGGAGAACGGCGACGTTCATGCGTTTGCCGACGAAGTGAGCGAGCTGGGCCGTACACTGCCGCGTTTCACTGCC
CATACCTGGTACCGCGAACCGACCGAGGCCGATCGCGCCCAACACGTCTTTGACAGCGAAGGGCTGATGGATTTAAGCAA
ACTGGAAGTCGCGATCAGCGATCCGGCAATGCAGTTCTATCTTTGCGGCCCGGTAGGCTTTATGCAGTTTGCCGCAAAAC
AACTGGTTTCACTTGGCGTGAATAACGAAAACATTCATTACGAATGCTTCGGCCCGCATAAAGTGCTGTAA

Upstream 100 bases:

>100_bases
TCCATAACGTAAAGCAGAGAAGAACCATTTACAATGCAAGGGTATTTTTATAAGATGCATTTGATATACATCATTAGATT
TTCACATAAAGGAAGCACGT

Downstream 100 bases:

>100_bases
TTGCAAGAAATCCTCTGAAAAAACGGGCGTTATCGTTAAGGCGAACGCCCGTTTTCCTCCCCGTTCCCCTGCTTATTACA
CTGCTTTTTATGCCTTTCTT

Product: nitric oxide dioxygenase

Products: NA

Alternate protein names: Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNAIAAYASNIENLPALLPAVEK
IAQKHTSFQIKPEQYNIVGTHLLATLDEMFNPGQEVLDAWGKAYGVLANVFIHREAEIYHENASKDGGWEGTRPFRIVAK
TPRSALITSFEFEPVDGGTVAEYRPGQYLGVWLKPEGFAHQEIRQYSLTRKPDGKGYRIAVKREDGGQVSNWLHHHASVG
DVVRLAAPAGDFFMNVAADTPVSLISAGVGQTPMLAMLDTLAKGQHTAQVNWFHAAENGDVHAFADEVSELGRTLPRFTA
HTWYREPTEADRAQHVFDSEGLMDLSKLEVAISDPAMQFYLCGPVGFMQFAAKQLVSLGVNNENIHYECFGPHKVL

Sequences:

>Translated_396_residues
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNAIAAYASNIENLPALLPAVEK
IAQKHTSFQIKPEQYNIVGTHLLATLDEMFNPGQEVLDAWGKAYGVLANVFIHREAEIYHENASKDGGWEGTRPFRIVAK
TPRSALITSFEFEPVDGGTVAEYRPGQYLGVWLKPEGFAHQEIRQYSLTRKPDGKGYRIAVKREDGGQVSNWLHHHASVG
DVVRLAAPAGDFFMNVAADTPVSLISAGVGQTPMLAMLDTLAKGQHTAQVNWFHAAENGDVHAFADEVSELGRTLPRFTA
HTWYREPTEADRAQHVFDSEGLMDLSKLEVAISDPAMQFYLCGPVGFMQFAAKQLVSLGVNNENIHYECFGPHKVL
>Mature_396_residues
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNAIAAYASNIENLPALLPAVEK
IAQKHTSFQIKPEQYNIVGTHLLATLDEMFNPGQEVLDAWGKAYGVLANVFIHREAEIYHENASKDGGWEGTRPFRIVAK
TPRSALITSFEFEPVDGGTVAEYRPGQYLGVWLKPEGFAHQEIRQYSLTRKPDGKGYRIAVKREDGGQVSNWLHHHASVG
DVVRLAAPAGDFFMNVAADTPVSLISAGVGQTPMLAMLDTLAKGQHTAQVNWFHAAENGDVHAFADEVSELGRTLPRFTA
HTWYREPTEADRAQHVFDSEGLMDLSKLEVAISDPAMQFYLCGPVGFMQFAAKQLVSLGVNNENIHYECFGPHKVL

Specific function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a centra

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788903, Length=396, Percent_Identity=91.4141414141414, Blast_Score=756, Evalue=0.0,
Organism=Escherichia coli, GI1787658, Length=215, Percent_Identity=26.9767441860465, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321673, Length=410, Percent_Identity=35.1219512195122, Blast_Score=212, Evalue=1e-55,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017927
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00042 Globin; PF00175 NAD_binding_1 [H]

EC number: =1.14.12.17 [H]

Molecular weight: Translated: 43960; Mature: 43960

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNA
CCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHH
IAAYASNIENLPALLPAVEKIAQKHTSFQIKPEQYNIVGTHLLATLDEMFNPGQEVLDAW
HHHHHHCHHHHHHHHHHHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHCCHHHHHHHH
GKAYGVLANVFIHREAEIYHENASKDGGWEGTRPFRIVAKTPRSALITSFEFEPVDGGTV
HHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCEEEEEECCCHHEEEEEEECCCCCCCC
AEYRPGQYLGVWLKPEGFAHQEIRQYSLTRKPDGKGYRIAVKREDGGQVSNWLHHHASVG
CCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCHH
DVVRLAAPAGDFFMNVAADTPVSLISAGVGQTPMLAMLDTLAKGQHTAQVNWFHAAENGD
HHHEEECCCCHHEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCC
VHAFADEVSELGRTLPRFTAHTWYREPTEADRAQHVFDSEGLMDLSKLEVAISDPAMQFY
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHEEEECCCCEEEE
LCGPVGFMQFAAKQLVSLGVNNENIHYECFGPHKVL
EECCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNA
CCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHH
IAAYASNIENLPALLPAVEKIAQKHTSFQIKPEQYNIVGTHLLATLDEMFNPGQEVLDAW
HHHHHHCHHHHHHHHHHHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHCCHHHHHHHH
GKAYGVLANVFIHREAEIYHENASKDGGWEGTRPFRIVAKTPRSALITSFEFEPVDGGTV
HHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCEEEEEECCCHHEEEEEEECCCCCCCC
AEYRPGQYLGVWLKPEGFAHQEIRQYSLTRKPDGKGYRIAVKREDGGQVSNWLHHHASVG
CCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCHH
DVVRLAAPAGDFFMNVAADTPVSLISAGVGQTPMLAMLDTLAKGQHTAQVNWFHAAENGD
HHHEEECCCCHHEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCC
VHAFADEVSELGRTLPRFTAHTWYREPTEADRAQHVFDSEGLMDLSKLEVAISDPAMQFY
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHEEEECCCCEEEE
LCGPVGFMQFAAKQLVSLGVNNENIHYECFGPHKVL
EECCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]