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The map label for this gene is cobB [H]

Identifier: 194736189

GI number: 194736189

Start: 2091951

End: 2093330

Strand: Reverse

Name: cobB [H]

Synonym: SeSA_A2204

Alternate gene names: 194736189

Gene position: 2093330-2091951 (Counterclockwise)

Preceding gene: 194736794

Following gene: 194737481

Centisome position: 44.45

GC content: 55.58

Gene sequence:

>1380_bases
ATGGCGGCAAGGCATCACGCATTTATTCTTGCAGGCACAGGAAGCGGTTGCGGCAAAACCACGGTGACGCTTGGTTTGTT
GAGGCTGCTGCAAAAACGCGCGCTGCGCGTACAGCCGTTTAAAGTTGGGCCAGATTACCTTGATACCGGCTGGCATACCG
CTATCTGTGGCGTGGCGTCCCGTAATCTTGACAGTTTCATGCTTCCTCCTCCTGTTCTCAACGCCTTATTTTGCGAACAA
ATGCGGCAGGCGGATATCGCCGTCATTGAAGGGGTCATGGGGCTGTATGACGGCTATGGCGTCGACCCCAATTATTGCAG
CACAGCCGCAATGGCGAAACAGCTTGGTTGCCCGGTCATCCTACTGGTGGACGGCAAGGCTGTTTCAACGTCGCTTGCGG
CTACCGTTATGGGATTTCAGCACTTCGACCCGACCCTCAACCTCGCGGGCGTGATTGTGAATCGCGTCACTAGCGACGCC
CACTATCAGCTCCTCAAAAATGCCATTGAACATTATTGCTCACTGCCGGTACTGGGGTATGTCCCTCCTTGCGACGGCGT
CGCATTACCTGAACGCCACCTGGGGTTGATTACCGCCAGAGAATCCCTCGTCAATCAGCAATCATGGCATGATTTTGCCG
CCACGCTGGAACAAACAGTGGATGTGGATGCGTTACTCTCGCTGAGCGTGTTATCAGCGCTTCCGGCGGGAATGTGGCCT
GAACGCCCCGATAACACAGCGGGGGCAGGGCTGACGCTTGCTCTGGCGGATGATGAAGCCTTTAACTTTTATTACCCCGA
TAACATCGATTTGCTGGAGCGTGCCGGCGTTAACATTGTGCGTTTTAGCCCACTGCATGACCGCGTATTGCCTGATTGTC
AGATGATCTGGCTGGGCGGTGGATATCCCGAATTATACGCCGCAGAGCTGGCGGCAAATACGGCGATGTTAAAACATTTG
CGGGCGGCGCATCAGCGCGGCGTGGCGATTTACGCGGAGTGTGGCGGTCTGATGTATTTGGGGAGCACTCTGGAGGATAG
CGGCGGGGAAATTCATCAGATGGCGAATATTATCCCCGGTCACAGCAAAATGGGTAAGCGACTTACCCGCTTTGGTTACT
GTGAGGCGCAGGCTATGCAGCCAACGCTATTGGCGGTGCCTGGTGAGATAGTGCGCGGCCATGAATTTCACTACTCAGAT
TTTATCCCCGAAACACCCGCCGTTATGGCCTGTCGTAAGGTTCGCGATGGTCGCGTGTTACAGGAATGGACCGGCGGCTG
GCAGACAGGCAACACGTTTGCCAGCTATCTGCACGTCCATTTCGCCCAGCGTCCGGAAATGTTGCAGCACTGGCTGGCGG
CGGCGAGGCGCATATTATGA

Upstream 100 bases:

>100_bases
AACAACTTCGGTGGGAAGTGGGTTGCGAAGACGCGTACAGTCGAAAGACTGAACATGCGCGTACCTGTATACCCCTACCA
CCCTGAACAGGATCAGGGTA

Downstream 100 bases:

>100_bases
CGATCCTTGCCTGGTGTGTCGCCTGGGTGCTGGATTTTATCATCGGCGACCCTCAACACTGGCCCCATCCGGTACGCTGG
ATAGGCCGTTTAATCACGTT

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MAARHHAFILAGTGSGCGKTTVTLGLLRLLQKRALRVQPFKVGPDYLDTGWHTAICGVASRNLDSFMLPPPVLNALFCEQ
MRQADIAVIEGVMGLYDGYGVDPNYCSTAAMAKQLGCPVILLVDGKAVSTSLAATVMGFQHFDPTLNLAGVIVNRVTSDA
HYQLLKNAIEHYCSLPVLGYVPPCDGVALPERHLGLITARESLVNQQSWHDFAATLEQTVDVDALLSLSVLSALPAGMWP
ERPDNTAGAGLTLALADDEAFNFYYPDNIDLLERAGVNIVRFSPLHDRVLPDCQMIWLGGGYPELYAAELAANTAMLKHL
RAAHQRGVAIYAECGGLMYLGSTLEDSGGEIHQMANIIPGHSKMGKRLTRFGYCEAQAMQPTLLAVPGEIVRGHEFHYSD
FIPETPAVMACRKVRDGRVLQEWTGGWQTGNTFASYLHVHFAQRPEMLQHWLAAARRIL

Sequences:

>Translated_459_residues
MAARHHAFILAGTGSGCGKTTVTLGLLRLLQKRALRVQPFKVGPDYLDTGWHTAICGVASRNLDSFMLPPPVLNALFCEQ
MRQADIAVIEGVMGLYDGYGVDPNYCSTAAMAKQLGCPVILLVDGKAVSTSLAATVMGFQHFDPTLNLAGVIVNRVTSDA
HYQLLKNAIEHYCSLPVLGYVPPCDGVALPERHLGLITARESLVNQQSWHDFAATLEQTVDVDALLSLSVLSALPAGMWP
ERPDNTAGAGLTLALADDEAFNFYYPDNIDLLERAGVNIVRFSPLHDRVLPDCQMIWLGGGYPELYAAELAANTAMLKHL
RAAHQRGVAIYAECGGLMYLGSTLEDSGGEIHQMANIIPGHSKMGKRLTRFGYCEAQAMQPTLLAVPGEIVRGHEFHYSD
FIPETPAVMACRKVRDGRVLQEWTGGWQTGNTFASYLHVHFAQRPEMLQHWLAAARRIL
>Mature_458_residues
AARHHAFILAGTGSGCGKTTVTLGLLRLLQKRALRVQPFKVGPDYLDTGWHTAICGVASRNLDSFMLPPPVLNALFCEQM
RQADIAVIEGVMGLYDGYGVDPNYCSTAAMAKQLGCPVILLVDGKAVSTSLAATVMGFQHFDPTLNLAGVIVNRVTSDAH
YQLLKNAIEHYCSLPVLGYVPPCDGVALPERHLGLITARESLVNQQSWHDFAATLEQTVDVDALLSLSVLSALPAGMWPE
RPDNTAGAGLTLALADDEAFNFYYPDNIDLLERAGVNIVRFSPLHDRVLPDCQMIWLGGGYPELYAAELAANTAMLKHLR
AAHQRGVAIYAECGGLMYLGSTLEDSGGEIHQMANIIPGHSKMGKRLTRFGYCEAQAMQPTLLAVPGEIVRGHEFHYSDF
IPETPAVMACRKVRDGRVLQEWTGGWQTGNTFASYLHVHFAQRPEMLQHWLAAARRIL

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: NA

Molecular weight: Translated: 50093; Mature: 49962

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARHHAFILAGTGSGCGKTTVTLGLLRLLQKRALRVQPFKVGPDYLDTGWHTAICGVAS
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCEECCEECCCCHHCCCHHHHHHHHHH
RNLDSFMLPPPVLNALFCEQMRQADIAVIEGVMGLYDGYGVDPNYCSTAAMAKQLGCPVI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
LLVDGKAVSTSLAATVMGFQHFDPTLNLAGVIVNRVTSDAHYQLLKNAIEHYCSLPVLGY
EEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEC
VPPCDGVALPERHLGLITARESLVNQQSWHDFAATLEQTVDVDALLSLSVLSALPAGMWP
CCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
ERPDNTAGAGLTLALADDEAFNFYYPDNIDLLERAGVNIVRFSPLHDRVLPDCQMIWLGG
CCCCCCCCCCEEEEEECCCCEEEECCCCCHHHHHCCCCEEEECCHHHHHCCCCEEEEECC
GYPELYAAELAANTAMLKHLRAAHQRGVAIYAECGGLMYLGSTLEDSGGEIHQMANIIPG
CCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCHHHHHHHHCCC
HSKMGKRLTRFGYCEAQAMQPTLLAVPGEIVRGHEFHYSDFIPETPAVMACRKVRDGRVL
HHHHHHHHHHHCCCHHHCCCCEEEECCHHHHCCCCCCHHCCCCCCHHHHHHHHHCCCCHH
QEWTGGWQTGNTFASYLHVHFAQRPEMLQHWLAAARRIL
HHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AARHHAFILAGTGSGCGKTTVTLGLLRLLQKRALRVQPFKVGPDYLDTGWHTAICGVAS
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCEECCEECCCCHHCCCHHHHHHHHHH
RNLDSFMLPPPVLNALFCEQMRQADIAVIEGVMGLYDGYGVDPNYCSTAAMAKQLGCPVI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
LLVDGKAVSTSLAATVMGFQHFDPTLNLAGVIVNRVTSDAHYQLLKNAIEHYCSLPVLGY
EEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEC
VPPCDGVALPERHLGLITARESLVNQQSWHDFAATLEQTVDVDALLSLSVLSALPAGMWP
CCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
ERPDNTAGAGLTLALADDEAFNFYYPDNIDLLERAGVNIVRFSPLHDRVLPDCQMIWLGG
CCCCCCCCCCEEEEEECCCCEEEECCCCCHHHHHCCCCEEEECCHHHHHCCCCEEEEECC
GYPELYAAELAANTAMLKHLRAAHQRGVAIYAECGGLMYLGSTLEDSGGEIHQMANIIPG
CCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCHHHHHHHHCCC
HSKMGKRLTRFGYCEAQAMQPTLLAVPGEIVRGHEFHYSDFIPETPAVMACRKVRDGRVL
HHHHHHHHHHHCCCHHHCCCCEEEECCHHHHCCCCCCHHCCCCCCHHHHHHHHHCCCCHH
QEWTGGWQTGNTFASYLHVHFAQRPEMLQHWLAAARRIL
HHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8501034; 11677609; 1374146 [H]