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The map label for this gene is metC [H]

Identifier: 194736125

GI number: 194736125

Start: 3226375

End: 3227562

Strand: Direct

Name: metC [H]

Synonym: SeSA_A3344

Alternate gene names: 194736125

Gene position: 3226375-3227562 (Clockwise)

Preceding gene: 194737525

Following gene: 194735483

Centisome position: 68.51

GC content: 54.04

Gene sequence:

>1188_bases
ATGACGGATAAACAGTTGGATACCAAACTGGTAAATGCAGGACGCAGCAGAAAATACACGCTTGGCTCAGTGAATAGTGT
GATTCAACGCGCTTCTTCACTGGTGTTTGACACCGTCGAGGCCAAAAAACACGCTACCCGCAATCGCGCCAACGGCGAAT
TATTTTACGGACGCCGGGGAACGCTGACCCACTTTTCGCTCCAGGAAGCCATGTGTGAACTGGAAGGCGGCGCCGGATGC
GCGCTCTTCCCGTGCGGCGCGGCGGCGGTCGCCAACACCATTCTGGCGTTCGTTGAGCAGGGCGACCACATCCTGATGAC
CAACACAGCCTATGAACCCAGCCAGGATTTCTGCAGCAAAATTCTCGGCAAACTGGGCGTGACGACAAGCTGGTTCGACC
CGCTCATCGGCGCTGATATCACGCAACATATTCAGCCGAACACGAAAGTCGTATTTCTGGAATCCCCCGGTTCTATTACC
ATGGAGGTACATGATATTCCGACCATTGTCAGTGCGGTCAGACGCGTCGCGCCAGAAGCCGTCATCATGATTGATAATAC
CTGGGCGGCTGGCGTTCTGTTCAAAGCTCTGGAATTCGATATTGATATCTCTATCCAGGCGGGCACTAAATATCTGATTG
GTCATTCTGATGCGATGGTCGGGACTGCCGTTGCAAATGCGCGCTGCTGGGAACAATTGCGGGAAAACGCCTATCTGATG
GGGCAAATGCTCGACGCCGACACGGCTTATATGACCAGCCGCGGTCTGCGCACGCTCGGTGTCCGACTGCGCCAGCATCA
AGAAAGCAGCCTCAAAATCGCCGCATGGCTGGCGAACCATCCTCAGGTCGCGCGCGTTAATCATCCGGCCCTGCCGGGTA
GCAAAGGTCATGCCTTCTGGAAACGAGACTTTACAGGCAGCAGCGGCCTGTTCTCCTTTGTGCTCAATAAAAAGCTGACC
GAGGCTGAATTATCAGCCTATCTGGATAACTTTTCGCTGTTCAGTATGGCCTACTCCTGGGGAGGCTACGAATCGCTGAT
TATTGCTAATCAGCCGGAACAGATCGCCGCGATTCGTCCCGCAGGCGGCGTAGATTTTACCGGTACGCTGGTTCGGGTGC
ATATTGGTTTAGAGAGTGTTGATGATTTGATCGCTGATTTAGCCGCCGGCTTCGCCAGAATTGTGTAA

Upstream 100 bases:

>100_bases
TTTTGGCAAAATTTTCATCTGTATCACACGTCGCCAGGGTGCAGATGGTTATATTCATGCTAGTTTAGACATCCAGACGG
TTAAAATCAGGAAACGCAAC

Downstream 100 bases:

>100_bases
AGTTGCCGGGGATGGACATATATGCAGACAATTTCCGTGGAAAAGTCTGCGTTTGTTGCGTCCGGGATCAAGGCATCCCG
GACGATTCAGGAGTACAATA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTDKQLDTKLVNAGRSRKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGC
ALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSKILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSIT
MEVHDIPTIVSAVRRVAPEAVIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLM
GQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHPQVARVNHPALPGSKGHAFWKRDFTGSSGLFSFVLNKKLT
EAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRPAGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV

Sequences:

>Translated_395_residues
MTDKQLDTKLVNAGRSRKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGC
ALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSKILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSIT
MEVHDIPTIVSAVRRVAPEAVIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLM
GQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHPQVARVNHPALPGSKGHAFWKRDFTGSSGLFSFVLNKKLT
EAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRPAGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV
>Mature_394_residues
TDKQLDTKLVNAGRSRKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGCA
LFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSKILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSITM
EVHDIPTIVSAVRRVAPEAVIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLMG
QMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHPQVARVNHPALPGSKGHAFWKRDFTGSSGLFSFVLNKKLTE
AELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRPAGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=292, Percent_Identity=31.1643835616438, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI299473759, Length=228, Percent_Identity=31.5789473684211, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI25453487, Length=326, Percent_Identity=27.3006134969325, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=86.5822784810127, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1790375, Length=341, Percent_Identity=32.5513196480938, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17560056, Length=329, Percent_Identity=31.9148936170213, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17538055, Length=332, Percent_Identity=29.5180722891566, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71980708, Length=376, Percent_Identity=28.1914893617021, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321170, Length=335, Percent_Identity=41.1940298507463, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319307, Length=354, Percent_Identity=31.3559322033898, Blast_Score=145, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6321254, Length=263, Percent_Identity=27.7566539923954, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321904, Length=252, Percent_Identity=30.1587301587302, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323333, Length=392, Percent_Identity=25.2551020408163, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922554, Length=337, Percent_Identity=32.3442136498516, Blast_Score=174, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42958; Mature: 42826

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKQLDTKLVNAGRSRKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRG
CCCHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
TLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSK
CEEEHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
ILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSITMEVHDIPTIVSAVRRVAPEA
HHHHHCCCHHHHHHHHCCCHHHHCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHCCCCE
VIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLM
EEEEECCHHHHHHHHHHHCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
GQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHPQVARVNHPALPGSKGHAFW
HHHHCCCHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCEE
KRDFTGSSGLFSFVLNKKLTEAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRP
EECCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHCCCCEEEEEEECCCCCEEEECC
AGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDKQLDTKLVNAGRSRKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRG
CCHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
TLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSK
CEEEHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
ILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSITMEVHDIPTIVSAVRRVAPEA
HHHHHCCCHHHHHHHHCCCHHHHCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHCCCCE
VIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLM
EEEEECCHHHHHHHHHHHCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
GQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHPQVARVNHPALPGSKGHAFW
HHHHCCCHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCEE
KRDFTGSSGLFSFVLNKKLTEAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRP
EECCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHCCCCEEEEEEECCCCCEEEECC
AGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659970; 11677609 [H]