Click here to switch to the map view.

The map label for this gene is cynR [H]

Identifier: 194735984

GI number: 194735984

Start: 2721832

End: 2722758

Strand: Direct

Name: cynR [H]

Synonym: SeSA_A2818

Alternate gene names: 194735984

Gene position: 2721832-2722758 (Clockwise)

Preceding gene: 194737916

Following gene: 194735481

Centisome position: 57.8

GC content: 43.04

Gene sequence:

>927_bases
ATGAATATCAAACAACTACATTCCTTCCTGATATTGTGTGATGAATTACATTATGGTCGGGCAGCCAGTCGCCTGTTTAT
CACTCAGCCATCATTAAGTCAGCAAATCAAACAACTTGAGTCATCACTTAAAACAATATTATTTAAGCGAAAAGGTAGAG
GAATTAAATTAACAAAAGCAGGTATTATTTTGCAACGACACGCTAACAAAATAATGCTGGATTTAAAAAATGCCGAAAAT
GAACTTCTTCCCTATCAGGATCAACAGCGCGATACTATTTCAATCGGGGTGTCAGGCAGCTACCTGGTCCTGCCCGCTTT
TCGCAGCTTTATGGCGCACCATCCGGAAATATCTTTAAATGTTAAAGAGTTCTCAACTGAGCAAACCATTAAAAGGCTGA
CGGATAGCGCCGTTGATATTGGCATTGTTTATCGAACAGCGCTCCCTGCCCAGCTAAGTTCGACCATGCTGTTTGAAGAT
GAAATTATCGCTGCAATCCCACTTTCTCATCCTCTGGCGACACGCGAACGTCTGCAGCTAAAAGATTTAAACGACCAGCC
CATTATCGTGCTTAATGACTCTCTGCTATTAAGAGGGATCATCACCACTGAATTTAATAACCGCAAAGTCGTTCCTAACG
TCATCTGCGAACTGGATAACCACTACTCATGCCTTGAGTATGCCGAAGCGCAGATTGGCATCGCATTTATTACCCGCTCG
CTAACCCATTTATCGACACCCAAAAATGTTCGCCTGGTTTCACTGGGCATCCCCGCATTCTTTATTCCTGTCATGCTGGT
GCACAGTAATGACCTTTCACTGGATAACGCAACCATCTGCCTGCTCAAGCAGATCAAAAATTTTTACACTGTAGATAACA
AATCAGCGCCAGAAAAGAGCTGGCCCGAGCAGAAAATAGGCGTATAA

Upstream 100 bases:

>100_bases
AAATGCACTGATCACAGTTTAAAAAAAGCAAAATAGGCAAACAATTTGGTATTTTTTATAATCGTTATAACAAAACCCAA
TCGATTGGCATTAAATTTTA

Downstream 100 bases:

>100_bases
TGCCCGCCCGATTTGTGTTGTTTCTGAGAATTTCCTGATGGCGCTGTTAATCACCAAAAAATGTATCAATTGCGATATGT
GCGAGCCGGAGTGCCCGAAT

Product: putative transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNIKQLHSFLILCDELHYGRAASRLFITQPSLSQQIKQLESSLKTILFKRKGRGIKLTKAGIILQRHANKIMLDLKNAEN
ELLPYQDQQRDTISIGVSGSYLVLPAFRSFMAHHPEISLNVKEFSTEQTIKRLTDSAVDIGIVYRTALPAQLSSTMLFED
EIIAAIPLSHPLATRERLQLKDLNDQPIIVLNDSLLLRGIITTEFNNRKVVPNVICELDNHYSCLEYAEAQIGIAFITRS
LTHLSTPKNVRLVSLGIPAFFIPVMLVHSNDLSLDNATICLLKQIKNFYTVDNKSAPEKSWPEQKIGV

Sequences:

>Translated_308_residues
MNIKQLHSFLILCDELHYGRAASRLFITQPSLSQQIKQLESSLKTILFKRKGRGIKLTKAGIILQRHANKIMLDLKNAEN
ELLPYQDQQRDTISIGVSGSYLVLPAFRSFMAHHPEISLNVKEFSTEQTIKRLTDSAVDIGIVYRTALPAQLSSTMLFED
EIIAAIPLSHPLATRERLQLKDLNDQPIIVLNDSLLLRGIITTEFNNRKVVPNVICELDNHYSCLEYAEAQIGIAFITRS
LTHLSTPKNVRLVSLGIPAFFIPVMLVHSNDLSLDNATICLLKQIKNFYTVDNKSAPEKSWPEQKIGV
>Mature_308_residues
MNIKQLHSFLILCDELHYGRAASRLFITQPSLSQQIKQLESSLKTILFKRKGRGIKLTKAGIILQRHANKIMLDLKNAEN
ELLPYQDQQRDTISIGVSGSYLVLPAFRSFMAHHPEISLNVKEFSTEQTIKRLTDSAVDIGIVYRTALPAQLSSTMLFED
EIIAAIPLSHPLATRERLQLKDLNDQPIIVLNDSLLLRGIITTEFNNRKVVPNVICELDNHYSCLEYAEAQIGIAFITRS
LTHLSTPKNVRLVSLGIPAFFIPVMLVHSNDLSLDNATICLLKQIKNFYTVDNKSAPEKSWPEQKIGV

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=30.1310043668122, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787879, Length=200, Percent_Identity=32.5, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367136, Length=269, Percent_Identity=29.368029739777, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790399, Length=205, Percent_Identity=27.8048780487805, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788887, Length=270, Percent_Identity=24.4444444444444, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788297, Length=244, Percent_Identity=25, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI145693105, Length=262, Percent_Identity=24.8091603053435, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790208, Length=260, Percent_Identity=23.4615384615385, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787601, Length=172, Percent_Identity=29.6511627906977, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081904, Length=195, Percent_Identity=25.6410256410256, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787589, Length=144, Percent_Identity=28.4722222222222, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34728; Mature: 34728

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKQLHSFLILCDELHYGRAASRLFITQPSLSQQIKQLESSLKTILFKRKGRGIKLTKA
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
GIILQRHANKIMLDLKNAENELLPYQDQQRDTISIGVSGSYLVLPAFRSFMAHHPEISLN
CEEEEECCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHCCCCEEEE
VKEFSTEQTIKRLTDSAVDIGIVYRTALPAQLSSTMLFEDEIIAAIPLSHPLATRERLQL
HHHHHHHHHHHHHHHCHHEEEEEEEECCCHHHHHHEEECCCEEEEECCCCCCCHHHHHHE
KDLNDQPIIVLNDSLLLRGIITTEFNNRKVVPNVICELDNHYSCLEYAEAQIGIAFITRS
ECCCCCCEEEECCCEEEEEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LTHLSTPKNVRLVSLGIPAFFIPVMLVHSNDLSLDNATICLLKQIKNFYTVDNKSAPEKS
HHHCCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHEECCCCCCCCCC
WPEQKIGV
CCCHHCCC
>Mature Secondary Structure
MNIKQLHSFLILCDELHYGRAASRLFITQPSLSQQIKQLESSLKTILFKRKGRGIKLTKA
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
GIILQRHANKIMLDLKNAENELLPYQDQQRDTISIGVSGSYLVLPAFRSFMAHHPEISLN
CEEEEECCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHCCCCEEEE
VKEFSTEQTIKRLTDSAVDIGIVYRTALPAQLSSTMLFEDEIIAAIPLSHPLATRERLQL
HHHHHHHHHHHHHHHCHHEEEEEEEECCCHHHHHHEEECCCEEEEECCCCCCCHHHHHHE
KDLNDQPIIVLNDSLLLRGIITTEFNNRKVVPNVICELDNHYSCLEYAEAQIGIAFITRS
ECCCCCCEEEECCCEEEEEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LTHLSTPKNVRLVSLGIPAFFIPVMLVHSNDLSLDNATICLLKQIKNFYTVDNKSAPEKS
HHHCCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHEECCCCCCCCCC
WPEQKIGV
CCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]