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The map label for this gene is sdaB [H]

Identifier: 194735968

GI number: 194735968

Start: 3026396

End: 3027763

Strand: Direct

Name: sdaB [H]

Synonym: SeSA_A3131

Alternate gene names: 194735968

Gene position: 3026396-3027763 (Clockwise)

Preceding gene: 194736684

Following gene: 194737620

Centisome position: 64.27

GC content: 56.14

Gene sequence:

>1368_bases
ATGATTAGCGTATTCGATATTTTTAAAATCGGCATTGGCCCTTCCAGTTCTCACACCGTCGGACCAATGAAAGCAGGCAA
GCAGTTCACGGACGATCTGATTGCCCGCCATATCCTTACAGATGTCACCCGCGTCGTGGTGGATGTCTACGGCTCTCTGT
CATTGACGGGTAAAGGCCACCACACTGATATCGCCATTATTATGGGCCTGGCGGGGAATCTGCCGGACACCGTCGATATC
GACGCCATTCCGTCCTTTATCCAGGATGTGAACACCCATGGGCGTTTACTACTGGCCAATGGGCAGCATGAAGTCGAATT
TCCGGTCGATAAGTGCATGAATTTCCACGCCGACAACCTGTCTCTGCATGAAAACGGGATGCGTATTACCGCGCTGGCGG
GCGATAAGGTGCTCTACAGCCAAACCTACTACTCCATTGGCGGCGGCTTTATCGTCGATGAAGAGCACTTTGGTTTGACG
AATAGCGAACCTGTTAACGTGCCGTACCCTTACAAAACCGCCGCGGATTTACAGCGTCACTGCCAGGAGACGGGTCTGTC
GCTCTCCGGTCTGATGATGCAAAACGAACTGGCTCTGCACAGTAAAGAAGCGCTGGAGCAGCACTTCGCCAGGGTCTGGG
AGGTAATGCGCAGCGGTATTGAGCGCGGTATCACCACCGAGGGCGTATTGCCGGGCAAACTGCGCGTTCCGCGTCGCGCG
GCGGCGCTGCGTCGGGTGCTGGTCAGTCAGGATAAGACCACCACCGATCCGATGGCGGTCGTCGACTGGATCAATATGTT
CGCGCTGGCGGTGAACGAAGAGAATGCCGCAGGCGGACGAGTAGTCACTGCGCCGACTAACGGCGCATGTGGTATTGTTC
CGGCGGTGCTGGCGTACTATGACAAGTTTATCCGCGAAGTAAATGCTAACTCACTTGCTCGCTATATGCTGGTCGCCAGC
GCGATTGGCTCGCTGTATAAGATGAACGCCTCTATTTCCGGCGCCGAAGTGGGTTGTCAGGGAGAGGTCGGCGTGGCCTG
TTCCATGGCGGCAGCGGGTCTGGCCGAGCTGCTGGGCGGTAGTCCGGCGCAGGTGTGTATCGCCGCAGAAATCGCCATGG
AGCATAATCTGGGGTTAACTTGCGATCCGGTTGCCGGTCAGGTACAGGTTCCCTGCATTGAGCGTAACGCGATTGCTTCA
GTCAAAGCAGTCAACGCCGCGCGTATGGCGCTGCGCCGTACCAGCGAACCGCGTGTATGCCTCGATAAAGTGATTGAGAC
CATGTACGAAACCGGTAAAGACATGAACGCTAAGTACCGCGAAACTTCGCGCGGCGGCCTGGCGATGAAGATCGTTACCT
GCGATTAA

Upstream 100 bases:

>100_bases
CTGATTGCCATCTCCGCTATTTTCTACTCACTGTTCAGCTAAGTCCTTTAGCGCCGCTTACCGCGGCGCTTCTCTATGAT
ACAACCGCAATGGATGCCCT

Downstream 100 bases:

>100_bases
TTCTCAGCACATTTTAGGATCTGTAGGCCGGATAAGGCGCTCGTCGCCATCCGGCTTTGTTGCCTGATGTCGCTTCGCTT
ATCAGGCCTACGGATAGCGC

Product: L-serine ammonia-lyase

Products: NA

Alternate protein names: SDH 2; L-serine deaminase 2; L-SD2 [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MISVFDIFKIGIGPSSSHTVGPMKAGKQFTDDLIARHILTDVTRVVVDVYGSLSLTGKGHHTDIAIIMGLAGNLPDTVDI
DAIPSFIQDVNTHGRLLLANGQHEVEFPVDKCMNFHADNLSLHENGMRITALAGDKVLYSQTYYSIGGGFIVDEEHFGLT
NSEPVNVPYPYKTAADLQRHCQETGLSLSGLMMQNELALHSKEALEQHFARVWEVMRSGIERGITTEGVLPGKLRVPRRA
AALRRVLVSQDKTTTDPMAVVDWINMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDKFIREVNANSLARYMLVAS
AIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPAQVCIAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAVNAARMALRRTSEPRVCLDKVIETMYETGKDMNAKYRETSRGGLAMKIVTCD

Sequences:

>Translated_455_residues
MISVFDIFKIGIGPSSSHTVGPMKAGKQFTDDLIARHILTDVTRVVVDVYGSLSLTGKGHHTDIAIIMGLAGNLPDTVDI
DAIPSFIQDVNTHGRLLLANGQHEVEFPVDKCMNFHADNLSLHENGMRITALAGDKVLYSQTYYSIGGGFIVDEEHFGLT
NSEPVNVPYPYKTAADLQRHCQETGLSLSGLMMQNELALHSKEALEQHFARVWEVMRSGIERGITTEGVLPGKLRVPRRA
AALRRVLVSQDKTTTDPMAVVDWINMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDKFIREVNANSLARYMLVAS
AIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPAQVCIAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAVNAARMALRRTSEPRVCLDKVIETMYETGKDMNAKYRETSRGGLAMKIVTCD
>Mature_455_residues
MISVFDIFKIGIGPSSSHTVGPMKAGKQFTDDLIARHILTDVTRVVVDVYGSLSLTGKGHHTDIAIIMGLAGNLPDTVDI
DAIPSFIQDVNTHGRLLLANGQHEVEFPVDKCMNFHADNLSLHENGMRITALAGDKVLYSQTYYSIGGGFIVDEEHFGLT
NSEPVNVPYPYKTAADLQRHCQETGLSLSGLMMQNELALHSKEALEQHFARVWEVMRSGIERGITTEGVLPGKLRVPRRA
AALRRVLVSQDKTTTDPMAVVDWINMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDKFIREVNANSLARYMLVAS
AIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPAQVCIAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAVNAARMALRRTSEPRVCLDKVIETMYETGKDMNAKYRETSRGGLAMKIVTCD

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1789161, Length=455, Percent_Identity=94.0659340659341, Blast_Score=895, Evalue=0.0,
Organism=Escherichia coli, GI1788116, Length=455, Percent_Identity=77.3626373626374, Blast_Score=734, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=452, Percent_Identity=73.0088495575221, Blast_Score=678, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48879; Mature: 48879

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVFDIFKIGIGPSSSHTVGPMKAGKQFTDDLIARHILTDVTRVVVDVYGSLSLTGKGH
CCCCEEEEEECCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
HTDIAIIMGLAGNLPDTVDIDAIPSFIQDVNTHGRLLLANGQHEVEFPVDKCMNFHADNL
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCEECCHHHHCCCCCCCC
SLHENGMRITALAGDKVLYSQTYYSIGGGFIVDEEHFGLTNSEPVNVPYPYKTAADLQRH
EEECCCEEEEEEECCEEEEEEHHEECCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
CQETGLSLSGLMMQNELALHSKEALEQHFARVWEVMRSGIERGITTEGVLPGKLRVPRRA
HHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AALRRVLVSQDKTTTDPMAVVDWINMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYY
HHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DKFIREVNANSLARYMLVASAIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGG
HHHHHHHCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPAQVCIAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIASVKAVNAARMALRRTSEPRVC
CCHHEEEEEEHHHHCCCCCEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHCCCCCHHH
LDKVIETMYETGKDMNAKYRETSRGGLAMKIVTCD
HHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECC
>Mature Secondary Structure
MISVFDIFKIGIGPSSSHTVGPMKAGKQFTDDLIARHILTDVTRVVVDVYGSLSLTGKGH
CCCCEEEEEECCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
HTDIAIIMGLAGNLPDTVDIDAIPSFIQDVNTHGRLLLANGQHEVEFPVDKCMNFHADNL
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCEECCHHHHCCCCCCCC
SLHENGMRITALAGDKVLYSQTYYSIGGGFIVDEEHFGLTNSEPVNVPYPYKTAADLQRH
EEECCCEEEEEEECCEEEEEEHHEECCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
CQETGLSLSGLMMQNELALHSKEALEQHFARVWEVMRSGIERGITTEGVLPGKLRVPRRA
HHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AALRRVLVSQDKTTTDPMAVVDWINMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYY
HHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DKFIREVNANSLARYMLVASAIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGG
HHHHHHHCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPAQVCIAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIASVKAVNAARMALRRTSEPRVC
CCHHEEEEEEHHHHCCCCCEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHCCCCCHHH
LDKVIETMYETGKDMNAKYRETSRGGLAMKIVTCD
HHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8385012; 9278503 [H]