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The map label for this gene is wecA [H]

Identifier: 194735803

GI number: 194735803

Start: 4005733

End: 4006836

Strand: Direct

Name: wecA [H]

Synonym: SeSA_A4129

Alternate gene names: 194735803

Gene position: 4005733-4006836 (Clockwise)

Preceding gene: 194736430

Following gene: 194736042

Centisome position: 85.06

GC content: 46.92

Gene sequence:

>1104_bases
GTGAAGTTACTCACCGCTTTATCTGAGCTAATCAGTATTTTTTTATTCACGACCATTTTTATTTTTCTTGCGCGAAAAGT
AGCCATAAAAATTGGTTTAGTGGATAAACCAAACTTTCGTAAACGACATCAGGGTGTTATCCCATTAGTCGGCGGGATTT
CTGTGTTTGCAGGAATCTGCTTTATGTTTGGCCTCTCGGATTACTACATACCGCACTTATCGCTATATCTTATTTGCGCT
GGTGTATTGGTTTTTGTTGGTGCGATGGATGACCGTTTTGATATCAGTGTAAAAATTCGTGCTGTGGTTCAGGCCGTTAT
TGCGGTTGTAATGATGGTTATCGCAAAACTTCACTTAGGTAGCCTTGGTTACATCTTTGGGCCTTGGGAGTTAGTGCTTG
GCCCCTTTGGCTATTTCCTTACCCTGTTTGCGGTATGGGCGGCGATCAACGCTTTCAATATGGTGGACGGTATTGACGGC
CTGCTGGGGGGGTTATCCAGCGTCTCATTTGCGGCGATGGGGCTGATTTTATGGTTTGATGGTCAGACTAGCCTGGCAAT
GTGGTGCTTTGCCATGATCGCCGCGATTCTGCCTTACATTATGCTTAATCTCGGTATTTTGGGGCGGCGTTATAAAGTCT
TTATGGGCGATGCCGGTAGTACACTGATTGGCTTTACCGTCATCTGGCTCTTACTGGAAACGACGCAGGGGAAAACTCAC
TCTATCAGCCCGGTTACTGCGCTATGGATTATCGCTATTCCATTGATGGATATGGTGGCGATTATGTATCGCCGTCTGCG
TAAAGGGATGAGCCCCTTTTCCCCTGATCGCCAACATATTCATCATTTGGTTATGCGAGCAGGGTTTACTTCCCGCCAGG
CATTTGTTCTTATTACGCTCGCAGCGGCGATTCTGGCGGGAGTAGGCGTAACGGCAGAATACTCTCATTTTGTTCCTGAA
TGGGTTATGTTGGTGCTCTTTTTGCTAGCATTCTTCCTCTATGGCTACTGCATTAAGCGGGCCTGGAAGGTGGCGAGATT
TATTAAGCGTGTGAAGCGTCGCCTGCGCAGGCAACGTGAGAACCGGCCAAACTTAACCAAGTAA

Upstream 100 bases:

>100_bases
GTTTGCGGTAAAAAGTGTAATGTTCTAACAGGTCTCTTCTAGGAGCTGGCGTAACGCATTATACTTTAAGGAAATGATAT
ATGCTGAGAGCACATACACT

Downstream 100 bases:

>100_bases
ATGAGGATACGATGACACAACCATTACCGGGGGCACGCGCGGTGAGCGCTGAAAATGAACTGGATATTCGCGGGTTGTTT
CGTACTTTATGGGCTGGCAA

Product: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKLLTALSELISIFLFTTIFIFLARKVAIKIGLVDKPNFRKRHQGVIPLVGGISVFAGICFMFGLSDYYIPHLSLYLICA
GVLVFVGAMDDRFDISVKIRAVVQAVIAVVMMVIAKLHLGSLGYIFGPWELVLGPFGYFLTLFAVWAAINAFNMVDGIDG
LLGGLSSVSFAAMGLILWFDGQTSLAMWCFAMIAAILPYIMLNLGILGRRYKVFMGDAGSTLIGFTVIWLLLETTQGKTH
SISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLVMRAGFTSRQAFVLITLAAAILAGVGVTAEYSHFVPE
WVMLVLFLLAFFLYGYCIKRAWKVARFIKRVKRRLRRQRENRPNLTK

Sequences:

>Translated_367_residues
MKLLTALSELISIFLFTTIFIFLARKVAIKIGLVDKPNFRKRHQGVIPLVGGISVFAGICFMFGLSDYYIPHLSLYLICA
GVLVFVGAMDDRFDISVKIRAVVQAVIAVVMMVIAKLHLGSLGYIFGPWELVLGPFGYFLTLFAVWAAINAFNMVDGIDG
LLGGLSSVSFAAMGLILWFDGQTSLAMWCFAMIAAILPYIMLNLGILGRRYKVFMGDAGSTLIGFTVIWLLLETTQGKTH
SISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLVMRAGFTSRQAFVLITLAAAILAGVGVTAEYSHFVPE
WVMLVLFLLAFFLYGYCIKRAWKVARFIKRVKRRLRRQRENRPNLTK
>Mature_367_residues
MKLLTALSELISIFLFTTIFIFLARKVAIKIGLVDKPNFRKRHQGVIPLVGGISVFAGICFMFGLSDYYIPHLSLYLICA
GVLVFVGAMDDRFDISVKIRAVVQAVIAVVMMVIAKLHLGSLGYIFGPWELVLGPFGYFLTLFAVWAAINAFNMVDGIDG
LLGGLSSVSFAAMGLILWFDGQTSLAMWCFAMIAAILPYIMLNLGILGRRYKVFMGDAGSTLIGFTVIWLLLETTQGKTH
SISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLVMRAGFTSRQAFVLITLAAAILAGVGVTAEYSHFVPE
WVMLVLFLLAFFLYGYCIKRAWKVARFIKRVKRRLRRQRENRPNLTK

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=367, Percent_Identity=87.4659400544959, Blast_Score=589, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 41087; Mature: 41087

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCC
>Mature Secondary Structure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CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]