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The map label for this gene is panF [H]

Identifier: 194735262

GI number: 194735262

Start: 3450471

End: 3451922

Strand: Direct

Name: panF [H]

Synonym: SeSA_A3574

Alternate gene names: 194735262

Gene position: 3450471-3451922 (Clockwise)

Preceding gene: 194735537

Following gene: 194734237

Centisome position: 73.27

GC content: 54.82

Gene sequence:

>1452_bases
ATGCAGCTTGAGGTCATTCTACCACTGGTAGCCTATCTGATCGTGGTCTTCGGAGTCTCGATTTACGCTATGCGCAAGCG
TACCGCCGGCACCTTTTTAAACGAATATTTTCTTGGCAGCCGTTCGATGGGCGGGATCGTGCTCGCGATGACGCTTACCG
CCACCTATATTAGCGCCAGTTCCTTTATCGGCGGTCCCGGCGCGGCTTATAAATACGGTCTGGGCTGGGTCTTGCTGGCG
ATGATCCAGCTTCCCGCCGTCTGGCTTTCACTGGGTATTCTGGGTAAAAAATTCGCTATCCTGGCGCGTCGCTATAATGC
CGTCACGCTTAACGATATGCTATTCGCTCGTTACCAAAGCCGCCTGCTGGTGTGGTTGGCAAGCCTGAGTTTATTGGTCG
CGTTTATTGGCGCAATGACCGTACAATTTATCGGCGGCGCGCGACTGCTGGAAACCGCGGCGGGAATTCCCTACGAAACC
GGCCTGCTAATATTTGGCGTCAGTATCGCACTCTATACGGCGTTTGGCGGCTTTCGCGCCAGCGTACTTAACGATACGCT
ACAGGGCCTGGTGATGCTGGTCGGCACGATAGTGCTGCTGGTGGGCGTGGTCCATGCGGCGGGCGGTCTAAGTCAGGCCG
TTGACACGCTGCACGCTCTCGACCCCAAACTGGTAACGCCGCAGGGTGCCGATGACATACTTTCTCCCGCTTTTATGACC
TCTTTTTGGGTACTGGTCTGTTTTGGCGTGATTGGCCTGCCGCATACGGCGGTGCGCTGCATCTCCTATAAAGACAGTAA
AGCGGTACACCGGGGCATTATTATCGGTACGATTGTCGTGGCGATTTTAATGTTCGGGATGCACCTTGCCGGCGCGCTGG
GTCGCGCGGTGCTTCCAGATCTGACGGTGCCGGATCTGGTGATCCCAACGCTAATGGTGAAAGTTTTGCCGCCGTTTGCC
GCCGGGATCTTCCTCGCTGCGCCAATGGCGGCGATCATGTCAACAATTAACGCCCAACTGCTGCAAAGTTCCGCGACGAT
CATTAAAGATCTCTATCTCAATCTACGCCCCGATCAGATGCAAAATGAGATCCGGCTGAAGCGTATGTCGGCAGCGATTA
CTTTACTGCTAGGCGCGCTGTTGCTGCTGGCAGCATGGAAACCGCCAGAGATGATCATTTGGCTCAACCTGCTGGCGTTT
GGCGGCCTAGAAGCGGTGTTCTTATGGCCGCTGGTACTGGGCCTTTACTGGGAGCGGGCAAACGCGGCAGGCGCATTAAG
CGCCATGATCGTGGGCGGCGTGCTATATGCCCTGCTTGCCACATTTAATATTCAGTACCTGGGCTTTCATCCGATTGTGC
CCGCGTTACTGTTAAGTTTATTGGCTTTTCTGATCGGAAACCGATTCGGCTCTTCCGCTTCGCAAGCCACCGTATTGTCT
ACTGATAAATAA

Upstream 100 bases:

>100_bases
TGGTTCGAGATGGCCTGCTTATTGACGCCGCTGGTCTTTATTTTGCTGTGCTGGGCGATGGTGAAATTCATTTATCGCGA
TATTCCGCTGGAGGATGACA

Downstream 100 bases:

>100_bases
AGAGTTTTGCCATGCCATGGATCCAATTGAAACTGAATACCACCGGCGCGAATGCTGAAGAGCTGAGTGATGCGCTGATG
GAAGCGGGCGCCGTTTCCAT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MQLEVILPLVAYLIVVFGVSIYAMRKRTAGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGVSIALYTAFGGFRASVLNDTLQGLVMLVGTIVLLVGVVHAAGGLSQAVDTLHALDPKLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVLPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNLRPDQMQNEIRLKRMSAAITLLLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYALLATFNIQYLGFHPIVPALLLSLLAFLIGNRFGSSASQATVLS
TDK

Sequences:

>Translated_483_residues
MQLEVILPLVAYLIVVFGVSIYAMRKRTAGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGVSIALYTAFGGFRASVLNDTLQGLVMLVGTIVLLVGVVHAAGGLSQAVDTLHALDPKLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVLPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNLRPDQMQNEIRLKRMSAAITLLLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYALLATFNIQYLGFHPIVPALLLSLLAFLIGNRFGSSASQATVLS
TDK
>Mature_483_residues
MQLEVILPLVAYLIVVFGVSIYAMRKRTAGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGVSIALYTAFGGFRASVLNDTLQGLVMLVGTIVLLVGVVHAAGGLSQAVDTLHALDPKLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVLPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNLRPDQMQNEIRLKRMSAAITLLLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYALLATFNIQYLGFHPIVPALLLSLLAFLIGNRFGSSASQATVLS
TDK

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=473, Percent_Identity=26.8498942917548, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=24.0585774058577, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4507033, Length=410, Percent_Identity=26.3414634146341, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4507031, Length=479, Percent_Identity=25.0521920668058, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI110835708, Length=491, Percent_Identity=23.4215885947047, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI4507035, Length=361, Percent_Identity=24.3767313019391, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI109659836, Length=494, Percent_Identity=24.0890688259109, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI157671931, Length=386, Percent_Identity=21.5025906735751, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87082237, Length=483, Percent_Identity=93.5817805383023, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=482, Percent_Identity=26.1410788381743, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1790113, Length=479, Percent_Identity=23.7995824634656, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790503, Length=492, Percent_Identity=22.1544715447154, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51585; Mature: 51585

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]