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The map label for this gene is aroE [H]

Identifier: 194735246

GI number: 194735246

Start: 3471180

End: 3471998

Strand: Reverse

Name: aroE [H]

Synonym: SeSA_A3598

Alternate gene names: 194735246

Gene position: 3471998-3471180 (Counterclockwise)

Preceding gene: 194734742

Following gene: 194737493

Centisome position: 73.73

GC content: 50.43

Gene sequence:

>819_bases
ATGGAAACCTATGCTGTTTTTGGAAATCCGATTGCTCACAGCAAATCGCCATTTATTCATCAGCAGTTTGCTCAGCAGCT
AGATATTGTTCACCCCTATGGTCGCGTGCTGGCCCCTATTAATAATTTCATTAATACGCTTGATGCCTTTTTCGCGGCAG
GGGGAAAAGGCGCAAACATCACAGTACCTTTTAAAGAGGAGGCGTTTGCGCGATCGGATGAGTTAACGGAACGAGCATCG
CTGGCGGGAGCAGTCAATACATTAAAGCGGCTGGAAGATGGTCGTTTGCTTGGCGACAATACTGACGGTATCGGTTTATT
AAGCGATCTCAAACGGTTAAATTTTATCCGCCCAGGATGGCGTATTTTGCTGATTGGCGCGGGCGGCGCATCCCGGGGCG
TGCTGTTACCTCTGCTTTCTTTGGATTGCGCGGTCACTATCACTAACCGTACAGCTTCACGTGCCGAAGCGTTGGCGAAA
ATCTTTGCTCATACCGGCAGCGTTCATGCCACGGATATGGACAAGCTGCATGGTTGTGAGTTTGACCTGATTATTAATGC
GACCTCCAGCGGCATACGGGGCGAAATCCCGGCGATTCCGGCGTCACTTATTCACCCTTCCCTCTGTTGCTATGACATGT
TCTATCAAAAAGGGAATACGCCATTTCTCTCCTGGTGTGTACAACAGGGCGCAAAACGATACGCAGATGGGCTGGGAATG
CTGGTGGGGCAGGCTGCACATGCCGTTTTGCTTTGGCACGGTGTATTACCGCAGGTCGAGCCAGTGATTGAGCTGCTACA
GCAGGAATTATTAGCGTGA

Upstream 100 bases:

>100_bases
GATGATTTTCCGGTGGTTGAAGGCGCAACGGGTGGGCGTTTAAATCCTTCAGAAATTCGCGATGCTCTGACGGGCGAACT
GTTTCGACAGGGGTAATATG

Downstream 100 bases:

>100_bases
ACCAGGCCATACAATTTCCTGACCGCGAAGAATGGGATACTGCCGCCAGCGCTGTCATCTTTCCCGCCATGGTCAATGGG
ATGCAACTCACGTGTGCAAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
METYAVFGNPIAHSKSPFIHQQFAQQLDIVHPYGRVLAPINNFINTLDAFFAAGGKGANITVPFKEEAFARSDELTERAS
LAGAVNTLKRLEDGRLLGDNTDGIGLLSDLKRLNFIRPGWRILLIGAGGASRGVLLPLLSLDCAVTITNRTASRAEALAK
IFAHTGSVHATDMDKLHGCEFDLIINATSSGIRGEIPAIPASLIHPSLCCYDMFYQKGNTPFLSWCVQQGAKRYADGLGM
LVGQAAHAVLLWHGVLPQVEPVIELLQQELLA

Sequences:

>Translated_272_residues
METYAVFGNPIAHSKSPFIHQQFAQQLDIVHPYGRVLAPINNFINTLDAFFAAGGKGANITVPFKEEAFARSDELTERAS
LAGAVNTLKRLEDGRLLGDNTDGIGLLSDLKRLNFIRPGWRILLIGAGGASRGVLLPLLSLDCAVTITNRTASRAEALAK
IFAHTGSVHATDMDKLHGCEFDLIINATSSGIRGEIPAIPASLIHPSLCCYDMFYQKGNTPFLSWCVQQGAKRYADGLGM
LVGQAAHAVLLWHGVLPQVEPVIELLQQELLA
>Mature_272_residues
METYAVFGNPIAHSKSPFIHQQFAQQLDIVHPYGRVLAPINNFINTLDAFFAAGGKGANITVPFKEEAFARSDELTERAS
LAGAVNTLKRLEDGRLLGDNTDGIGLLSDLKRLNFIRPGWRILLIGAGGASRGVLLPLLSLDCAVTITNRTASRAEALAK
IFAHTGSVHATDMDKLHGCEFDLIINATSSGIRGEIPAIPASLIHPSLCCYDMFYQKGNTPFLSWCVQQGAKRYADGLGM
LVGQAAHAVLLWHGVLPQVEPVIELLQQELLA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=84.5588235294118, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1787983, Length=287, Percent_Identity=28.2229965156794, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320332, Length=160, Percent_Identity=36.25, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29399; Mature: 29399

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METYAVFGNPIAHSKSPFIHQQFAQQLDIVHPYGRVLAPINNFINTLDAFFAAGGKGANI
CCCEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
TVPFKEEAFARSDELTERASLAGAVNTLKRLEDGRLLGDNTDGIGLLSDLKRLNFIRPGW
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCCC
RILLIGAGGASRGVLLPLLSLDCAVTITNRTASRAEALAKIFAHTGSVHATDMDKLHGCE
EEEEEECCCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCC
FDLIINATSSGIRGEIPAIPASLIHPSLCCYDMFYQKGNTPFLSWCVQQGAKRYADGLGM
EEEEEECCCCCCCCCCCCCCHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LVGQAAHAVLLWHGVLPQVEPVIELLQQELLA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
METYAVFGNPIAHSKSPFIHQQFAQQLDIVHPYGRVLAPINNFINTLDAFFAAGGKGANI
CCCEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
TVPFKEEAFARSDELTERASLAGAVNTLKRLEDGRLLGDNTDGIGLLSDLKRLNFIRPGW
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCCC
RILLIGAGGASRGVLLPLLSLDCAVTITNRTASRAEALAKIFAHTGSVHATDMDKLHGCE
EEEEEECCCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCC
FDLIINATSSGIRGEIPAIPASLIHPSLCCYDMFYQKGNTPFLSWCVQQGAKRYADGLGM
EEEEEECCCCCCCCCCCCCCHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LVGQAAHAVLLWHGVLPQVEPVIELLQQELLA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA