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The map label for this gene is pdxK [H]

Identifier: 194735083

GI number: 194735083

Start: 2550405

End: 2551271

Strand: Reverse

Name: pdxK [H]

Synonym: SeSA_A2671

Alternate gene names: 194735083

Gene position: 2551271-2550405 (Counterclockwise)

Preceding gene: 194738174

Following gene: 194736239

Centisome position: 54.18

GC content: 56.86

Gene sequence:

>867_bases
ATGGGACAAGAGAGTGATATTCAGTCAGTGCTCTTCGACGACAACCATCGGGCGTTACAGACCGATATCGTCGCTGTCCA
GTCACAGGTCGTGTACGGCAGCGTAGGCAACAGCATCGCTGTTCCGGCCATTAAAGCGCAGGGATTACGCGTGGCGGCTG
TCCCGACGGTGCTGTTCAGCAATACGCCGCACTATAAAACCTTTTATGGCGGCATTATTCCCGCCGAGTGGTTTGCAGGC
TACCTTACGGCGTTGAATGAGCGCGATGCGCTACGTGAATTAAAAGCGATTACCACCGGTTACATGGGCAGCGCAGACCA
AATTGTCTTGCTTTCGAAGTGGCTAATGGCGATCCGGGCTTCGCATCCGGAGGTGTGTATTCTTGTTGATCCGGTCATTG
GCGATACCGACAGTGGAATGTATGTGCAGGCGGAAATTCCGAAGGCTTATCGCACACATTTGTTGCCGCAGGCGCAGGGG
CTAACGCCGAACGTATTTGAGCTGGAGATGCTGAGTGGTAAACCGTGTCGCACGCTGGAAGAGGCGGTGGCGGCGGCGCA
ATCGCTGCTTTCCGATACGCTGAAATGGGTGGTTATCACCAGCGCGCCGGGCGAATCTCTGGAGACCATAACGGTTGCCG
TCGTTACCGCGCAGGTCGTGGAGGTCTTTGCCCACCCGCGGGTGGCGACGGAATTAAAAGGGACGGGAGATCTCTTCTGC
GCCGAGCTGGTCAGCGGTATTGTGCAGGGAAAAAAACTGACGACCGCGGCAAAAGATGCGGCGCAGCGCGTGCTGGAGGT
GATGACCTGGACACAGCAGTGTGGCTGTGATGAGTTAATTCTGCCGCCGGCAGGGGAGGCGCGATGA

Upstream 100 bases:

>100_bases
GGTTTTTCCGTCGATCATTATTGACCTATGACAAAATGAATTTTAGCATATGACAATGATAATGAGGCGGTAGCCTGCTG
TCCAGCGAGAGGAAAATTTT

Downstream 100 bases:

>100_bases
AGAGTTATCGGCTGGTAGTTCGCCAGCAGGGACGTATCGTGGGGCATTTTGAAACGAGCGGGCTGGACGCGCTGGAAGAT
ATTTGCGTAGCGCGGGCGAT

Product: pyridoxal kinase

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MGQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVAAVPTVLFSNTPHYKTFYGGIIPAEWFAG
YLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRASHPEVCILVDPVIGDTDSGMYVQAEIPKAYRTHLLPQAQG
LTPNVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFC
AELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR

Sequences:

>Translated_288_residues
MGQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVAAVPTVLFSNTPHYKTFYGGIIPAEWFAG
YLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRASHPEVCILVDPVIGDTDSGMYVQAEIPKAYRTHLLPQAQG
LTPNVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFC
AELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR
>Mature_287_residues
GQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVAAVPTVLFSNTPHYKTFYGGIIPAEWFAGY
LTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRASHPEVCILVDPVIGDTDSGMYVQAEIPKAYRTHLLPQAQGL
TPNVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFCA
ELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=270, Percent_Identity=26.2962962962963, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788758, Length=279, Percent_Identity=67.741935483871, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1787924, Length=259, Percent_Identity=28.957528957529, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17507759, Length=263, Percent_Identity=29.277566539924, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17507757, Length=272, Percent_Identity=30.1470588235294, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320806, Length=258, Percent_Identity=27.906976744186, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324354, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45553007, Length=233, Percent_Identity=30.4721030042918, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 30938; Mature: 30807

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVAAVPTVLFS
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCEECCEECCCCEEEEEECHHEEC
NTPHYKTFYGGIIPAEWFAGYLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRA
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SHPEVCILVDPVIGDTDSGMYVQAEIPKAYRTHLLPQAQGLTPNVFELEMLSGKPCRTLE
CCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHH
EAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFC
HHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHH
AELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCC
>Mature Secondary Structure 
GQESDIQSVLFDDNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVAAVPTVLFS
CCHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCEECCEECCCCEEEEEECHHEEC
NTPHYKTFYGGIIPAEWFAGYLTALNERDALRELKAITTGYMGSADQIVLLSKWLMAIRA
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SHPEVCILVDPVIGDTDSGMYVQAEIPKAYRTHLLPQAQGLTPNVFELEMLSGKPCRTLE
CCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHH
EAVAAAQSLLSDTLKWVVITSAPGESLETITVAVVTAQVVEVFAHPRVATELKGTGDLFC
HHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHH
AELVSGIVQGKKLTTAAKDAAQRVLEVMTWTQQCGCDELILPPAGEAR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA