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The map label for this gene is uvrD [H]

Identifier: 194734777

GI number: 194734777

Start: 4034783

End: 4036945

Strand: Direct

Name: uvrD [H]

Synonym: SeSA_A4161

Alternate gene names: 194734777

Gene position: 4034783-4036945 (Clockwise)

Preceding gene: 194734329

Following gene: 194737409

Centisome position: 85.68

GC content: 57.42

Gene sequence:

>2163_bases
ATGGACGTTTCTTACCTGCTCGACAGCCTTAATGATAAACAGCGCGAAGCGGTGGCCGCGCCACGTAGCAACATGCTGGT
GTTGGCGGGCGCGGGAAGCGGGAAAACCCGCGTGCTGGTGCACCGTATCGCCTGGTTACTGAGCGTAGAAAACAACTCGC
CATATTCCATCATGGCGGTGACCTTTACCAACAAAGCGGCGGCGGAAATGCGCCATCGTATTGGCCAGTTGATGGGGACC
AGCCAGGGCGGAATGTGGGTTGGGACGTTCCACGGTCTGGCGCACCGCCTGCTGCGCGCGCATCATATGGACGCTAATTT
GCCGCAGGATTTCCAGATTCTCGACAGCGAAGATCAGATGCGTTTGCTTAAACGCCTGATTAAGGCGATGAATCTTGATG
AGAAGCAGTGGCCGCCGCGTCAGGCGATGTGGTACATCAATAGCCAGAAAGACGAAGGGCTACGCCCGCACCATATCCAA
AGCTATGGCAATCCGGTGGAACAGACCTGGCAGAAGGTGTATCAGGCCTATCAGGAAGCGTGCGATCGCGCTGGTCTGGT
GGATTTTGCCGAGCTACTGCTGCGCGCTCATGAACTATGGCTGAACAAGCCGCACATCCTGCAACACTATCGCGAGCGGT
TTACTAACATTCTGGTGGACGAATTCCAGGATACCAACAATATTCAGTACGCCTGGGTTCGTCTGCTGGCGGGCGATACC
GGTAAAGTGATGATTGTCGGCGACGATGACCAGTCGATCTACGGCTGGCGCGGGGCCCAGGTAGAAAACATCCAGCGCTT
CCTCAATGATTTCCCCGGCGCGCAGACCATTCGTCTGGAGCAGAATTACCGCTCGACCAGCAACATCCTTAGCGCGGCGA
ACGCTCTGATTGAGAATAACAATGGGCGTCTGGGTAAAAAACTGTGGACTGACGGCGTTGATGGCGAACCGATATCGCTG
TACTGCGCTTTCAACGAACTGGATGAAGCGCGCTTTGTGGTTAACCGTATCAAAACCTGGCAGGACAACGGCGGCGCGCT
TGCGCAATGCGCCATCCTTTATCGCAGCAACGCCCAGTCGCGCGTGCTGGAAGAAGCGTTATTACAGGCCAGTATGCCGT
ACCGGATTTACGGCGGTATGCGCTTCTTCGAACGCCAGGAGATCAAAGATGCGCTCTCTTATCTGCGTTTGATTGCCAAT
CGCAACGATGATGCCGCCTTTGAACGCGTGGTGAACACCCCGACGCGCGGCATCGGCGACCGTACGCTGGACGTGGTGCG
CCAGACCTCGCGCGATCGCCAGCTAACATTGTGGCAAGCGTGCCGTGAATTGTTACAGGAAAAAGCCCTGGCCGGGCGTG
CGGCCAGCGCGCTACAACGCTTTATGGAACTGATCGATGCTCTGGCGCAGGAAACCGCCGACATGCCGCTGCATGTGCAG
ACTGACCGGGTGATCAAAGATTCCGGCCTGCGCACCATGTATGAGCAAGAAAAAGGCGAGAAAGGCCAGACGCGCATCGA
AAACTTAGAGGAACTGGTGACGGCGACGCGGCAGTTCAGCTACAACGACGAAGATGAAGATTTAATGCCGTTGCAGGCCT
TCCTCTCTCATGCGGCGCTGGAAGCGGGCGAGGGGCAGGCGGATACCTGGCAGGATGCAGTACAGCTGATGACGCTGCAC
TCGGCCAAAGGGCTGGAGTTTCCGCAGGTGTTTATCGTCGGTATGGAAGAGGGCATGTTCCCCAGCCAGATGTCGCTGGA
TGAGGGCGGGCGTTTGGAAGAGGAGCGTCGTCTGGCCTACGTCGGCGTTACCCGTGCCATGCAGAAACTAACGCTAACCT
ATGCCGAAACGCGTCGTCTGTACGGTAAAGAGGTCTACCATCGCCCGTCGCGTTTTATCGGCGAACTGCCGGAGGAGTGC
GTGGAAGAGGTCCGTCTGCGCGCCACCGTCAGTCGTCCGGTGAGCCATCAACGAATGGGAACGCCGCTGGCGGAAAACGA
CACAGGCTACAAACTCGGCCAACGCGTGCGCCATGCGAAGTTCGGCGAGGGAACTATTGTCAACCTGGAGGGCAGCGGCG
AGCATAGCCGGTTGCAGGTGGCTTTTCAGGGGCAAGGGATCAAATGGCTGGTTGCCGCGTATGCGAAGCTGGAAACGGTT
TGA

Upstream 100 bases:

>100_bases
GGCGGATGGCGTTATGCTTATCCGCCCTACGATAAGTAGCCCCGGTAAGCGAAGCGCCACCGGGCGTTTTTAGTTTTCAT
GTTTTTACGCGGCGGTGCCA

Downstream 100 bases:

>100_bases
CCGGCTCTCATATTGCCGGATGGCACCTCTTATCCGGCCTACGCGCTGGCTAACATTTTGATTTGTAGGCCGGATAAGGC
GAAGCCGCCATCCGGCGATA

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MDVSYLLDSLNDKQREAVAAPRSNMLVLAGAGSGKTRVLVHRIAWLLSVENNSPYSIMAVTFTNKAAAEMRHRIGQLMGT
SQGGMWVGTFHGLAHRLLRAHHMDANLPQDFQILDSEDQMRLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQ
SYGNPVEQTWQKVYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWVRLLAGDT
GKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAQTIRLEQNYRSTSNILSAANALIENNNGRLGKKLWTDGVDGEPISL
YCAFNELDEARFVVNRIKTWQDNGGALAQCAILYRSNAQSRVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIAN
RNDDAAFERVVNTPTRGIGDRTLDVVRQTSRDRQLTLWQACRELLQEKALAGRAASALQRFMELIDALAQETADMPLHVQ
TDRVIKDSGLRTMYEQEKGEKGQTRIENLEELVTATRQFSYNDEDEDLMPLQAFLSHAALEAGEGQADTWQDAVQLMTLH
SAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPEEC
VEEVRLRATVSRPVSHQRMGTPLAENDTGYKLGQRVRHAKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYAKLETV

Sequences:

>Translated_720_residues
MDVSYLLDSLNDKQREAVAAPRSNMLVLAGAGSGKTRVLVHRIAWLLSVENNSPYSIMAVTFTNKAAAEMRHRIGQLMGT
SQGGMWVGTFHGLAHRLLRAHHMDANLPQDFQILDSEDQMRLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQ
SYGNPVEQTWQKVYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWVRLLAGDT
GKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAQTIRLEQNYRSTSNILSAANALIENNNGRLGKKLWTDGVDGEPISL
YCAFNELDEARFVVNRIKTWQDNGGALAQCAILYRSNAQSRVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIAN
RNDDAAFERVVNTPTRGIGDRTLDVVRQTSRDRQLTLWQACRELLQEKALAGRAASALQRFMELIDALAQETADMPLHVQ
TDRVIKDSGLRTMYEQEKGEKGQTRIENLEELVTATRQFSYNDEDEDLMPLQAFLSHAALEAGEGQADTWQDAVQLMTLH
SAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPEEC
VEEVRLRATVSRPVSHQRMGTPLAENDTGYKLGQRVRHAKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYAKLETV
>Mature_720_residues
MDVSYLLDSLNDKQREAVAAPRSNMLVLAGAGSGKTRVLVHRIAWLLSVENNSPYSIMAVTFTNKAAAEMRHRIGQLMGT
SQGGMWVGTFHGLAHRLLRAHHMDANLPQDFQILDSEDQMRLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQ
SYGNPVEQTWQKVYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWVRLLAGDT
GKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAQTIRLEQNYRSTSNILSAANALIENNNGRLGKKLWTDGVDGEPISL
YCAFNELDEARFVVNRIKTWQDNGGALAQCAILYRSNAQSRVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIAN
RNDDAAFERVVNTPTRGIGDRTLDVVRQTSRDRQLTLWQACRELLQEKALAGRAASALQRFMELIDALAQETADMPLHVQ
TDRVIKDSGLRTMYEQEKGEKGQTRIENLEELVTATRQFSYNDEDEDLMPLQAFLSHAALEAGEGQADTWQDAVQLMTLH
SAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPEEC
VEEVRLRATVSRPVSHQRMGTPLAENDTGYKLGQRVRHAKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYAKLETV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=720, Percent_Identity=97.9166666666667, Blast_Score=1474, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=641, Percent_Identity=38.0655226209048, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=28.2352941176471, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322369, Length=734, Percent_Identity=26.7029972752044, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324477, Length=693, Percent_Identity=22.9437229437229, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81954; Mature: 81954

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSYLLDSLNDKQREAVAAPRSNMLVLAGAGSGKTRVLVHRIAWLLSVENNSPYSIMAV
CCHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHEECCCCCEEEEEE
TFTNKAAAEMRHRIGQLMGTSQGGMWVGTFHGLAHRLLRAHHMDANLPQDFQILDSEDQM
EECCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHH
RLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQSYGNPVEQTWQKVYQAYQEA
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHH
CDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWVRLLAGDT
HHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEHHEEEECCC
GKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAQTIRLEQNYRSTSNILSAANALIENN
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
NGRLGKKLWTDGVDGEPISLYCAFNELDEARFVVNRIKTWQDNGGALAQCAILYRSNAQS
CCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHH
RVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIANRNDDAAFERVVNTPTRGIGD
HHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
RTLDVVRQTSRDRQLTLWQACRELLQEKALAGRAASALQRFMELIDALAQETADMPLHVQ
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TDRVIKDSGLRTMYEQEKGEKGQTRIENLEELVTATRQFSYNDEDEDLMPLQAFLSHAAL
CCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EAGEGQADTWQDAVQLMTLHSAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAY
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
VGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPEECVEEVRLRATVSRPVSHQRMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHCC
TPLAENDTGYKLGQRVRHAKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYAKLETV
CCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDVSYLLDSLNDKQREAVAAPRSNMLVLAGAGSGKTRVLVHRIAWLLSVENNSPYSIMAV
CCHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHEECCCCCEEEEEE
TFTNKAAAEMRHRIGQLMGTSQGGMWVGTFHGLAHRLLRAHHMDANLPQDFQILDSEDQM
EECCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHH
RLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQSYGNPVEQTWQKVYQAYQEA
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHH
CDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWVRLLAGDT
HHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEHHEEEECCC
GKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAQTIRLEQNYRSTSNILSAANALIENN
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
NGRLGKKLWTDGVDGEPISLYCAFNELDEARFVVNRIKTWQDNGGALAQCAILYRSNAQS
CCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHH
RVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIANRNDDAAFERVVNTPTRGIGD
HHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
RTLDVVRQTSRDRQLTLWQACRELLQEKALAGRAASALQRFMELIDALAQETADMPLHVQ
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TDRVIKDSGLRTMYEQEKGEKGQTRIENLEELVTATRQFSYNDEDEDLMPLQAFLSHAAL
CCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EAGEGQADTWQDAVQLMTLHSAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAY
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
VGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPEECVEEVRLRATVSRPVSHQRMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHCC
TPLAENDTGYKLGQRVRHAKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYAKLETV
CCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]