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The map label for this gene is dcuS [H]

Identifier: 194734757

GI number: 194734757

Start: 4440472

End: 4442103

Strand: Reverse

Name: dcuS [H]

Synonym: SeSA_A4559

Alternate gene names: 194734757

Gene position: 4442103-4440472 (Counterclockwise)

Preceding gene: 194736039

Following gene: 194737202

Centisome position: 94.33

GC content: 53.25

Gene sequence:

>1632_bases
ATGAAACACTCCCTGCCATGCCGGGCGTTACGCAAACGCCCCATGAAACTCGGCACTACCGTCATTCTGATGGTCAGCGC
CGTTTTGTTTTCGGTGCTCGTTGTGGTCCATCTGATCTATTTTTCGCAAATCAGCAGCATGACGCGCGACGCGCTGGCAG
ATAAAGCGCTGGCGGTGGCGCGCTCGCTGGCGGACTCTCCGGCAATTCGCGAGGGGCTGAAAAAACCGCCTGCGGAAAGC
GGCATTCAGACGCTCGCCGAAGCGGTGAGCCAGCATAATGGCTTTTTGTTTATTGTGGTGACCAACATGCAGGGCATCCG
TTATTCACACCCAGAAACGCAGCGAATCGGCCAACCGTTCAAAGGCGATGACATTCTGCTCGCGCTGCAGGGAAAGGAAA
ACGTTGCCATTAATCGCGGCTTTCTTGCCAAAGCGCTGCGCGTTTTCACACCGGTTTATGATGAACGCCACCGGCAGATC
GGTGTGGTAGCGATCGGCCTGGAACTCAGTCACGTTACGCAGCAGATCAACAATAGCCGCGGCAGTATTATCTGGTCCAT
TCTGTTCGGCGCTCTGGTGGGGTTATTAGGCACGTATGCGCTGGTCAAGGTGCTAAAACGTATCCTGTTTGGCCTCGAAC
CCTATGAGATCTCAACCCTGTTTGAACAACGCCAGGCGATGCTGCAGTCAATCAAAGAGGGCGTTATCGCCGTGGATGAT
AGCGGCGAAGTCACGTTGATTAACCATGCGGCGCAGACGCTGCTCGATTATCGAAAAACGCAGGATGACGCCAGATTATC
CACCCTGAGTCATGCCTGGTCGCAGGTGGTGGACATTAGCGAAGTGTTGCGTGACGGTACGCCGCGCCGCGATGAAGAGA
TTATCGTCAAAGGCCGCCTGCTGCTGGTGAATACCGTTCCGGTGCGCAGCAACGGCGAAATTATCGGCGCGATATCCACC
TTCAGGGATAAAACAGAAGTTCGCCAACTGATGCAGCGGTTGGACGGGATGGTGAACTACGCGGATGCGCTCCGTGAACG
ATCCCACGAATTCATGAACAAATTACATGTGATTCTGGGATTATTGCACCTGAAGAGTTATAAGCAGCTTGAAGCGTATA
TTATCAAGACGGCCAATAACTATCAGGAAGAGATCGGTTTGCTGCTGGGTAAAATAAAGTCGCCGATTATCGCTGGCTTT
TTGCTCAGTAAAATTACTCGCGCCTCTGATTTCGGGCACAGCCTGGTGATAAGCAGCGACAGCCAGTTACCGGATAATAA
CAATGAAGATCAGGTTACGGTGCTGATTACGGCGCTGGGTAATTTGATTGAAAACGCGCTGGAAGCATTGAGCCAGGAAT
CCGGCGGCGAAATCAGCGTCTCGTTACACTACCGCCATGGCTGGCTGCATTGCGAAGTGAGCGATGACGGTCCGGGTATC
GAACCTGAGCGCATCGAGGCGATTTTTGAAAAAGGCGTCTCGTCGAAAGGCGCCGAACGCGGCGTCGGTTTAGCGCTGGT
TAAACAGCAGGTTGAAGCGCTTGGCGGCGTAATTTCCGTGGAGTCCGAGCCTGGGATCTTCACACAATTTTTTGTACAGT
TACCCTGGGATGGAAAAAGGACCAGCCTATGA

Upstream 100 bases:

>100_bases
TAAGACGGGCTTTTCAACACTGGAGCAACATCGCCTATGCCTTTGAATTAGACGCCTCATCAGGGATAATAACCTTACGA
TTCGTCCGCTCAGGTCCACT

Downstream 100 bases:

>100_bases
TCAATGTATTAATTGTCGATGACGATGCGATGGTCGCGGAGTTAAATCGCCGCTATGTCGCGCAAATCTCCGGTTTTCAT
TGTTGTGGAACCGCTTCGAC

Product: sensory histidine kinase DcuS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MKHSLPCRALRKRPMKLGTTVILMVSAVLFSVLVVVHLIYFSQISSMTRDALADKALAVARSLADSPAIREGLKKPPAES
GIQTLAEAVSQHNGFLFIVVTNMQGIRYSHPETQRIGQPFKGDDILLALQGKENVAINRGFLAKALRVFTPVYDERHRQI
GVVAIGLELSHVTQQINNSRGSIIWSILFGALVGLLGTYALVKVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDD
SGEVTLINHAAQTLLDYRKTQDDARLSTLSHAWSQVVDISEVLRDGTPRRDEEIIVKGRLLLVNTVPVRSNGEIIGAIST
FRDKTEVRQLMQRLDGMVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEAYIIKTANNYQEEIGLLLGKIKSPIIAGF
LLSKITRASDFGHSLVISSDSQLPDNNNEDQVTVLITALGNLIENALEALSQESGGEISVSLHYRHGWLHCEVSDDGPGI
EPERIEAIFEKGVSSKGAERGVGLALVKQQVEALGGVISVESEPGIFTQFFVQLPWDGKRTSL

Sequences:

>Translated_543_residues
MKHSLPCRALRKRPMKLGTTVILMVSAVLFSVLVVVHLIYFSQISSMTRDALADKALAVARSLADSPAIREGLKKPPAES
GIQTLAEAVSQHNGFLFIVVTNMQGIRYSHPETQRIGQPFKGDDILLALQGKENVAINRGFLAKALRVFTPVYDERHRQI
GVVAIGLELSHVTQQINNSRGSIIWSILFGALVGLLGTYALVKVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDD
SGEVTLINHAAQTLLDYRKTQDDARLSTLSHAWSQVVDISEVLRDGTPRRDEEIIVKGRLLLVNTVPVRSNGEIIGAIST
FRDKTEVRQLMQRLDGMVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEAYIIKTANNYQEEIGLLLGKIKSPIIAGF
LLSKITRASDFGHSLVISSDSQLPDNNNEDQVTVLITALGNLIENALEALSQESGGEISVSLHYRHGWLHCEVSDDGPGI
EPERIEAIFEKGVSSKGAERGVGLALVKQQVEALGGVISVESEPGIFTQFFVQLPWDGKRTSL
>Mature_543_residues
MKHSLPCRALRKRPMKLGTTVILMVSAVLFSVLVVVHLIYFSQISSMTRDALADKALAVARSLADSPAIREGLKKPPAES
GIQTLAEAVSQHNGFLFIVVTNMQGIRYSHPETQRIGQPFKGDDILLALQGKENVAINRGFLAKALRVFTPVYDERHRQI
GVVAIGLELSHVTQQINNSRGSIIWSILFGALVGLLGTYALVKVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDD
SGEVTLINHAAQTLLDYRKTQDDARLSTLSHAWSQVVDISEVLRDGTPRRDEEIIVKGRLLLVNTVPVRSNGEIIGAIST
FRDKTEVRQLMQRLDGMVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEAYIIKTANNYQEEIGLLLGKIKSPIIAGF
LLSKITRASDFGHSLVISSDSQLPDNNNEDQVTVLITALGNLIENALEALSQESGGEISVSLHYRHGWLHCEVSDDGPGI
EPERIEAIFEKGVSSKGAERGVGLALVKQQVEALGGVISVESEPGIFTQFFVQLPWDGKRTSL

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG3290

COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790567, Length=542, Percent_Identity=82.1033210332103, Blast_Score=927, Evalue=0.0,
Organism=Escherichia coli, GI1786837, Length=532, Percent_Identity=27.2556390977444, Blast_Score=188, Evalue=1e-48,
Organism=Escherichia coli, GI1788549, Length=347, Percent_Identity=25.6484149855908, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=348, Percent_Identity=25.8620689655172, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR016120
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59918; Mature: 59918

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHSLPCRALRKRPMKLGTTVILMVSAVLFSVLVVVHLIYFSQISSMTRDALADKALAVA
CCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLADSPAIREGLKKPPAESGIQTLAEAVSQHNGFLFIVVTNMQGIRYSHPETQRIGQPF
HHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHCCCCC
KGDDILLALQGKENVAINRGFLAKALRVFTPVYDERHRQIGVVAIGLELSHVTQQINNSR
CCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCCC
GSIIWSILFGALVGLLGTYALVKVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECC
SGEVTLINHAAQTLLDYRKTQDDARLSTLSHAWSQVVDISEVLRDGTPRRDEEIIVKGRL
CCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECEE
LLVNTVPVRSNGEIIGAISTFRDKTEVRQLMQRLDGMVNYADALRERSHEFMNKLHVILG
EEEEEECCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLHLKSYKQLEAYIIKTANNYQEEIGLLLGKIKSPIIAGFLLSKITRASDFGHSLVISSD
HHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SQLPDNNNEDQVTVLITALGNLIENALEALSQESGGEISVSLHYRHGWLHCEVSDDGPGI
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEECCCCCCC
EPERIEAIFEKGVSSKGAERGVGLALVKQQVEALGGVISVESEPGIFTQFFVQLPWDGKR
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCEEHHEEECCCCCCC
TSL
CCC
>Mature Secondary Structure
MKHSLPCRALRKRPMKLGTTVILMVSAVLFSVLVVVHLIYFSQISSMTRDALADKALAVA
CCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLADSPAIREGLKKPPAESGIQTLAEAVSQHNGFLFIVVTNMQGIRYSHPETQRIGQPF
HHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHCCCCC
KGDDILLALQGKENVAINRGFLAKALRVFTPVYDERHRQIGVVAIGLELSHVTQQINNSR
CCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCCC
GSIIWSILFGALVGLLGTYALVKVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECC
SGEVTLINHAAQTLLDYRKTQDDARLSTLSHAWSQVVDISEVLRDGTPRRDEEIIVKGRL
CCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECEE
LLVNTVPVRSNGEIIGAISTFRDKTEVRQLMQRLDGMVNYADALRERSHEFMNKLHVILG
EEEEEECCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLHLKSYKQLEAYIIKTANNYQEEIGLLLGKIKSPIIAGFLLSKITRASDFGHSLVISSD
HHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SQLPDNNNEDQVTVLITALGNLIENALEALSQESGGEISVSLHYRHGWLHCEVSDDGPGI
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEECCCCCCC
EPERIEAIFEKGVSSKGAERGVGLALVKQQVEALGGVISVESEPGIFTQFFVQLPWDGKR
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCEEHHEEECCCCCCC
TSL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]