Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 194734617

GI number: 194734617

Start: 4653859

End: 4654920

Strand: Direct

Name: glmS [H]

Synonym: SeSA_A4793

Alternate gene names: 194734617

Gene position: 4653859-4654920 (Clockwise)

Preceding gene: 194734138

Following gene: 194736701

Centisome position: 98.83

GC content: 52.73

Gene sequence:

>1062_bases
ATGTCACCAACCATGCTGACCTATATTAACGAAGAGTCTGACGTCCTGGCGAATATTATTCTCCGCCATCGCCAGTCGCT
GGAAGAAGTATCGCGGTTCGCCAGCCAAAAAACGTTACGACGAATCCTGATATTAGCCACCGGATCGTCATTGAATGCCG
CCTTTTGCGCCCGTTATTTCTTTGAGCGCTGCGGTATCTCTATCGATATTAAAGAGCCGTACACCTTTAGTCATTATGAG
AATAGCGATCCGCAAGCCGATATGGTTATTGCTATTTCCCAGAGCGGGAAAAGCGCTTCTACCCTGGAGGCGATGCGTAA
AGTTCAGGCGCAGGGACGTCCGGTATTCGCTCTGACCGCCGATCCGCAAAGCCCTTTTGGCAAGGCCAGCGATTATCCAC
TGGATATTCTGACCGGGATTGAGTCCGTCGGCTTTGTTACCCGTGGATTTAGCGCGACGGTACTGAATCTGTTGCTTATC
GCGTTGTTAATTGCCCGTCAGCAGCAGCGACTGACGGAATCGCAGGTCGAGGAGTATGTGGCGCAGCTTCAACGCATCGC
GGCAACCCTGCCGTTGGTTATCGTGCGTACGGAAGCGTTTATTCACCAGCACCAGTCCGTTTTACGAAACGGGACGCGTT
TTGTGGCGATAGGCTACGGCGCGCTGGTTGGGGTGGCAAAAGAGTTGGAAACTAAATTTACCGAGACGGTGCGTGTTCCC
TCAAGCGGGTTTGAGCTGGAAGCCTATATGCACGGCCCGTATCTGGAAGCCAATGCGGAACATGTGATGTTCTTCTTTGA
GGACCGGCCCGACGCGCGCTCCAGGGCGCTACGGGAGTATATGACGCCTGCGGTCGCCAAAACCTTTACTCTCACGCTGG
CGAAGGCGGCGCAGGATGACCAGACGCTTGCGCTGGATGTAGCGGTTGATCACCATTTCTCGCCATTGCTGTTGATTGTG
CCGGTACAACTCATGGCGTTTCATATCGCCTCACTGAAAGGCATCGACCTTTCGGTACGCATTTTTGACGATTTCGATCG
CGTTTTAAAAAGTAAAATCTGA

Upstream 100 bases:

>100_bases
GCTGTTAGGGAAAAAAGTGAAACCGTTAACCATCATTGGCGGTATTGCGCTGGTGGGAATTTTCGGTTCCTGGATAGGGT
TATTTTAAGAGGGATACACA

Downstream 100 bases:

>100_bases
ACAATCAGGAGAAAAATATGTTGGGTTTTAATCAGGACGAGTACCTGACGAGTGCTCGTGAGATCATCGCTGCGCGCCAG
AAGGCAGAACAGGTTGCTGA

Product: glucosamine--fructose-6-phosphate aminotransferase (isomerizing)

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSPTMLTYINEESDVLANIILRHRQSLEEVSRFASQKTLRRILILATGSSLNAAFCARYFFERCGISIDIKEPYTFSHYE
NSDPQADMVIAISQSGKSASTLEAMRKVQAQGRPVFALTADPQSPFGKASDYPLDILTGIESVGFVTRGFSATVLNLLLI
ALLIARQQQRLTESQVEEYVAQLQRIAATLPLVIVRTEAFIHQHQSVLRNGTRFVAIGYGALVGVAKELETKFTETVRVP
SSGFELEAYMHGPYLEANAEHVMFFFEDRPDARSRALREYMTPAVAKTFTLTLAKAAQDDQTLALDVAVDHHFSPLLLIV
PVQLMAFHIASLKGIDLSVRIFDDFDRVLKSKI

Sequences:

>Translated_353_residues
MSPTMLTYINEESDVLANIILRHRQSLEEVSRFASQKTLRRILILATGSSLNAAFCARYFFERCGISIDIKEPYTFSHYE
NSDPQADMVIAISQSGKSASTLEAMRKVQAQGRPVFALTADPQSPFGKASDYPLDILTGIESVGFVTRGFSATVLNLLLI
ALLIARQQQRLTESQVEEYVAQLQRIAATLPLVIVRTEAFIHQHQSVLRNGTRFVAIGYGALVGVAKELETKFTETVRVP
SSGFELEAYMHGPYLEANAEHVMFFFEDRPDARSRALREYMTPAVAKTFTLTLAKAAQDDQTLALDVAVDHHFSPLLLIV
PVQLMAFHIASLKGIDLSVRIFDDFDRVLKSKI
>Mature_352_residues
SPTMLTYINEESDVLANIILRHRQSLEEVSRFASQKTLRRILILATGSSLNAAFCARYFFERCGISIDIKEPYTFSHYEN
SDPQADMVIAISQSGKSASTLEAMRKVQAQGRPVFALTADPQSPFGKASDYPLDILTGIESVGFVTRGFSATVLNLLLIA
LLIARQQQRLTESQVEEYVAQLQRIAATLPLVIVRTEAFIHQHQSVLRNGTRFVAIGYGALVGVAKELETKFTETVRVPS
SGFELEAYMHGPYLEANAEHVMFFFEDRPDARSRALREYMTPAVAKTFTLTLAKAAQDDQTLALDVAVDHHFSPLLLIVP
VQLMAFHIASLKGIDLSVRIFDDFDRVLKSKI

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=362, Percent_Identity=22.9281767955801, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532899, Length=309, Percent_Identity=22.6537216828479, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21357745, Length=326, Percent_Identity=22.0858895705521, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 39349; Mature: 39218

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTMLTYINEESDVLANIILRHRQSLEEVSRFASQKTLRRILILATGSSLNAAFCARYF
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHH
FERCGISIDIKEPYTFSHYENSDPQADMVIAISQSGKSASTLEAMRKVQAQGRPVFALTA
HHHCCCEEECCCCEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEC
DPQSPFGKASDYPLDILTGIESVGFVTRGFSATVLNLLLIALLIARQQQRLTESQVEEYV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLQRIAATLPLVIVRTEAFIHQHQSVLRNGTRFVAIGYGALVGVAKELETKFTETVRVP
HHHHHHHHHHCHHEEHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHEECC
SSGFELEAYMHGPYLEANAEHVMFFFEDRPDARSRALREYMTPAVAKTFTLTLAKAAQDD
CCCCEEEEEECCCEEECCCCEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
QTLALDVAVDHHFSPLLLIVPVQLMAFHIASLKGIDLSVRIFDDFDRVLKSKI
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
SPTMLTYINEESDVLANIILRHRQSLEEVSRFASQKTLRRILILATGSSLNAAFCARYF
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHH
FERCGISIDIKEPYTFSHYENSDPQADMVIAISQSGKSASTLEAMRKVQAQGRPVFALTA
HHHCCCEEECCCCEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEC
DPQSPFGKASDYPLDILTGIESVGFVTRGFSATVLNLLLIALLIARQQQRLTESQVEEYV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLQRIAATLPLVIVRTEAFIHQHQSVLRNGTRFVAIGYGALVGVAKELETKFTETVRVP
HHHHHHHHHHCHHEEHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHEECC
SSGFELEAYMHGPYLEANAEHVMFFFEDRPDARSRALREYMTPAVAKTFTLTLAKAAQDD
CCCCEEEEEECCCEEECCCCEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
QTLALDVAVDHHFSPLLLIVPVQLMAFHIASLKGIDLSVRIFDDFDRVLKSKI
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA