Click here to switch to the map view.

The map label for this gene is lsrK [H]

Identifier: 194734566

GI number: 194734566

Start: 4157655

End: 4159205

Strand: Reverse

Name: lsrK [H]

Synonym: SeSA_A4288

Alternate gene names: 194734566

Gene position: 4159205-4157655 (Counterclockwise)

Preceding gene: 194734803

Following gene: 194735168

Centisome position: 88.32

GC content: 55.13

Gene sequence:

>1551_bases
ATGGCTCTTGACGCCGGTACCGGTAGCGTCAGAGCAGTAATTTTTGATCTACAAGGAAAGCAAATAGCTGTCGGTCAAGC
GGAATGGCAGCATCTGGCCGTGCCGGATGTGCCTGGTTCGATGGAGTTTGATCTTGCCAAAAACTGGCAACTGGCTTGCC
AGTGTATCCGTCAGGCACTACAGAAAGCCGCCATCCCTGCAACGGCTATCGCTGCCGTATCGGCCTGCTCGATGCGTGAA
GGCATTGTTATTTATGACAGTAACGGCGAACCAATTTGGGCCTGCGCTAATGTTGACGCCCGCGCGGCGCACGAAGTCAG
TGAATTAAAAGAGCTGCACGATAACACCTTTGAGGAGGAAGTTTATCGTTGCTCCGGGCAAACGCTGGCGCTCAGCGCTA
TTCCGCGTCTGCTCTGGCTTGCCCACCATCGTCCGGATATTTATCATCGCGCGTCAACCGTCACTATGATCAGCGACTGG
ATGGCCTTTATGCTCAGCGGCGAACTGGCGGTCGATCCCTCCAACGCAGGCACGACGGGGTTATTGGATCTGGTGACCCG
CAACTGGAAACGTAGCCTGTTACAGATGGCGGGCCTGCGTTCTGACATTCTCTCGCCGGTAAAAGAAACCGGGACGCTGC
TCGGTCACATTTCACAGAAAGCGGCTGAACAGTGCGACCTGCAAGCGGGTACGCCGGTCATCGTTGGCGGCGGCGATGTG
CAGTTAGGCTGTCTGGGGCTGGGCGTCGTACGCCCGGCGCAAACGGCCGTGCTGGGCGGAACCTTCTGGCAACAGGTCGT
CAATCTTCCCACGCCGGTCACCGACCCAAACATGAACGTTCGCATCAATCCTCATGTGATCCCCGGTATGGTACAAACCG
AATCTATTAGCTTTTTTACTGGGTTAACGATGCGTTGGTTCCGCGACGCCTTTTGCGCCGAGGAAAAACTAATCGCTGAA
AGGTTAGGTATTGATGCGTATTCCCTGCTGGAAGATATGGCCAGCCGGGTTCCTCCCGGCGCGCACGGTGTGATGCCCAT
CTTCTCTGACGTTATGCGTTTTAAACGCTGGTACCATGCCGCTCCGTCGTTTATCAATCTGTCTATCGATCCTGAAAAGT
GTAATAAAGCGACCCTATTTCGCGCGCTGGAAGAGAATGCCGCCATTGTTTCCGCCTGCAATTTACAGCAAATTGCCGCG
TTTTCCGGCGTACAGGCCGACTCGCTGGTTTTTGCCGGTGGAGGATCTAAAGGCAAATTATGGAGCCAAATCCTTGCCGA
CGTTACGGGACTCACCGTTCACGTACCTGTCGTCAAAGAAGCTACCGCGCTAGGGTGCGCTATTGCCGCAGGCGTTGGCG
TGGGTATCTGGCCATCGCTGGCGGAAACGGGAGAAAAGCTAGTGCGCTGGGATCGGGAGCATAAACCTAATCCTGAAAAT
TTCGCTGTCTACCAGCAGGCCAGAGAAAAATGGCAGGCCGTTTATCAGGATCAACGCGCGCTGGTCGATGGTGGCTTAAC
GACATCCCTCTGGAAAGCGCCAGGCCTGTAA

Upstream 100 bases:

>100_bases
ATAAACAATAACTGACAGGATTTTATGTAACGATGTAAAAATAGCCGAGGATAAAAAAATGGCTCGACTCTGTACCCATA
CTGAATCAGGACATTACCTG

Downstream 100 bases:

>100_bases
CAGGAGAATAAGCATGCAAAAAACGAATGAGAAGAATCATGAATACCGCTTTGGCGATAATGGCCCTAAATACTTAATCC
GTGGGCCGGGCTGCGATATG

Product: autoinducer-2 (AI-2) kinase

Products: NA

Alternate protein names: AI-2 kinase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MALDAGTGSVRAVIFDLQGKQIAVGQAEWQHLAVPDVPGSMEFDLAKNWQLACQCIRQALQKAAIPATAIAAVSACSMRE
GIVIYDSNGEPIWACANVDARAAHEVSELKELHDNTFEEEVYRCSGQTLALSAIPRLLWLAHHRPDIYHRASTVTMISDW
MAFMLSGELAVDPSNAGTTGLLDLVTRNWKRSLLQMAGLRSDILSPVKETGTLLGHISQKAAEQCDLQAGTPVIVGGGDV
QLGCLGLGVVRPAQTAVLGGTFWQQVVNLPTPVTDPNMNVRINPHVIPGMVQTESISFFTGLTMRWFRDAFCAEEKLIAE
RLGIDAYSLLEDMASRVPPGAHGVMPIFSDVMRFKRWYHAAPSFINLSIDPEKCNKATLFRALEENAAIVSACNLQQIAA
FSGVQADSLVFAGGGSKGKLWSQILADVTGLTVHVPVVKEATALGCAIAAGVGVGIWPSLAETGEKLVRWDREHKPNPEN
FAVYQQAREKWQAVYQDQRALVDGGLTTSLWKAPGL

Sequences:

>Translated_516_residues
MALDAGTGSVRAVIFDLQGKQIAVGQAEWQHLAVPDVPGSMEFDLAKNWQLACQCIRQALQKAAIPATAIAAVSACSMRE
GIVIYDSNGEPIWACANVDARAAHEVSELKELHDNTFEEEVYRCSGQTLALSAIPRLLWLAHHRPDIYHRASTVTMISDW
MAFMLSGELAVDPSNAGTTGLLDLVTRNWKRSLLQMAGLRSDILSPVKETGTLLGHISQKAAEQCDLQAGTPVIVGGGDV
QLGCLGLGVVRPAQTAVLGGTFWQQVVNLPTPVTDPNMNVRINPHVIPGMVQTESISFFTGLTMRWFRDAFCAEEKLIAE
RLGIDAYSLLEDMASRVPPGAHGVMPIFSDVMRFKRWYHAAPSFINLSIDPEKCNKATLFRALEENAAIVSACNLQQIAA
FSGVQADSLVFAGGGSKGKLWSQILADVTGLTVHVPVVKEATALGCAIAAGVGVGIWPSLAETGEKLVRWDREHKPNPEN
FAVYQQAREKWQAVYQDQRALVDGGLTTSLWKAPGL
>Mature_515_residues
ALDAGTGSVRAVIFDLQGKQIAVGQAEWQHLAVPDVPGSMEFDLAKNWQLACQCIRQALQKAAIPATAIAAVSACSMREG
IVIYDSNGEPIWACANVDARAAHEVSELKELHDNTFEEEVYRCSGQTLALSAIPRLLWLAHHRPDIYHRASTVTMISDWM
AFMLSGELAVDPSNAGTTGLLDLVTRNWKRSLLQMAGLRSDILSPVKETGTLLGHISQKAAEQCDLQAGTPVIVGGGDVQ
LGCLGLGVVRPAQTAVLGGTFWQQVVNLPTPVTDPNMNVRINPHVIPGMVQTESISFFTGLTMRWFRDAFCAEEKLIAER
LGIDAYSLLEDMASRVPPGAHGVMPIFSDVMRFKRWYHAAPSFINLSIDPEKCNKATLFRALEENAAIVSACNLQQIAAF
SGVQADSLVFAGGGSKGKLWSQILADVTGLTVHVPVVKEATALGCAIAAGVGVGIWPSLAETGEKLVRWDREHKPNPENF
AVYQQAREKWQAVYQDQRALVDGGLTTSLWKAPGL

Specific function: Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787789, Length=516, Percent_Identity=83.3333333333333, Blast_Score=898, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=497, Percent_Identity=22.7364185110664, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1790361, Length=494, Percent_Identity=26.5182186234818, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789168, Length=503, Percent_Identity=23.4592445328032, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1789138, Length=472, Percent_Identity=23.3050847457627, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789987, Length=507, Percent_Identity=24.0631163708087, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17535599, Length=470, Percent_Identity=23.8297872340426, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: NA

Molecular weight: Translated: 55832; Mature: 55700

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDAGTGSVRAVIFDLQGKQIAVGQAEWQHLAVPDVPGSMEFDLAKNWQLACQCIRQAL
CCCCCCCCCEEEEEEECCCCEEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
QKAAIPATAIAAVSACSMREGIVIYDSNGEPIWACANVDARAAHEVSELKELHDNTFEEE
HHHCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHH
VYRCSGQTLALSAIPRLLWLAHHRPDIYHRASTVTMISDWMAFMLSGELAVDPSNAGTTG
HHHHCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHH
LLDLVTRNWKRSLLQMAGLRSDILSPVKETGTLLGHISQKAAEQCDLQAGTPVIVGGGDV
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCE
QLGCLGLGVVRPAQTAVLGGTFWQQVVNLPTPVTDPNMNVRINPHVIPGMVQTESISFFT
EEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEECCCHHHH
GLTMRWFRDAFCAEEKLIAERLGIDAYSLLEDMASRVPPGAHGVMPIFSDVMRFKRWYHA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
APSFINLSIDPEKCNKATLFRALEENAAIVSACNLQQIAAFSGVQADSLVFAGGGSKGKL
CCCEEEEEECHHHCCHHHHHHHHHHCCCEEECCCHHHHHHHCCCCCCCEEEECCCCCCHH
WSQILADVTGLTVHVPVVKEATALGCAIAAGVGVGIWPSLAETGEKLVRWDREHKPNPEN
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCH
FAVYQQAREKWQAVYQDQRALVDGGLTTSLWKAPGL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure 
ALDAGTGSVRAVIFDLQGKQIAVGQAEWQHLAVPDVPGSMEFDLAKNWQLACQCIRQAL
CCCCCCCCEEEEEEECCCCEEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
QKAAIPATAIAAVSACSMREGIVIYDSNGEPIWACANVDARAAHEVSELKELHDNTFEEE
HHHCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHH
VYRCSGQTLALSAIPRLLWLAHHRPDIYHRASTVTMISDWMAFMLSGELAVDPSNAGTTG
HHHHCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHH
LLDLVTRNWKRSLLQMAGLRSDILSPVKETGTLLGHISQKAAEQCDLQAGTPVIVGGGDV
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCE
QLGCLGLGVVRPAQTAVLGGTFWQQVVNLPTPVTDPNMNVRINPHVIPGMVQTESISFFT
EEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEECCCHHHH
GLTMRWFRDAFCAEEKLIAERLGIDAYSLLEDMASRVPPGAHGVMPIFSDVMRFKRWYHA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
APSFINLSIDPEKCNKATLFRALEENAAIVSACNLQQIAAFSGVQADSLVFAGGGSKGKL
CCCEEEEEECHHHCCHHHHHHHHHHCCCEEECCCHHHHHHHCCCCCCCEEEECCCCCCHH
WSQILADVTGLTVHVPVVKEATALGCAIAAGVGVGIWPSLAETGEKLVRWDREHKPNPEN
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCH
FAVYQQAREKWQAVYQDQRALVDGGLTTSLWKAPGL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA