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The map label for this gene is zitB [H]

Identifier: 194734527

GI number: 194734527

Start: 887586

End: 888524

Strand: Reverse

Name: zitB [H]

Synonym: SeSA_A0917

Alternate gene names: 194734527

Gene position: 888524-887586 (Counterclockwise)

Preceding gene: 194738341

Following gene: 194738356

Centisome position: 18.87

GC content: 54.85

Gene sequence:

>939_bases
ATGGCGCACTCACACTCTCATGCCGATTCACACCTGCCGAAAGATAATAATGCTCGTCGCCTGCTTTTCGCCTTTATCGT
CACTGCCGGATTTATGCTCCTTGAGGTGGTGGGCGGGATACTCTCCGGCTCTCTGGCGTTGTTGGCGGATGCGGGACATA
TGCTCACCGACGCGGCGGCCCTTCTCTTTGCGCTGCTGGCGGTTCAATTTTCCCGTCGTCCTCCGACTGTTCGCCACACT
TTTGGCTGGCTAAGACTCACCACACTGGCGGCCTTTGTGAATGCCATTGCGTTGGTGGTCATTACCCTTCTCATTGTCTG
GGAAGCGATAGAGCGCTTTTACACGCCACGTCCGGTGGCGGGTAATCTGATGATGGTGATTGCGGTCGCGGGTCTGCTGG
CGAACCTGTTTGCATTCTGGATTCTCCATCGGGGAAGCGATGAAAAAAACCTGAACGTGCGCGCTGCCGCGCTACATGTG
ATGGGCGATTTGCTGGGTTCCGTCGGCGCAATAGTCGCCGCGCTGATCATTATCTGGACGGGCTGGACGCCAGCGGACCC
GATTCTCTCTATTCTGGTTTCGGTACTGGTGCTACGCAGCGCCTGGCGTTTGTTAAAAGATAGCGTCAACGAATTGCTGG
AAGGCGCACCGGTTTCGCTGGATATTAATGCCTTACAGCGCCATTTAAGCCGGGAAATCCCCGAAGTCCGCAACGTACAC
CATGTGCATGTCTGGATGGTCGGCGAAAAACCGATCATGACATTGCACGCTCAGGTCATTCCGCCACACGACCATGATGC
GCTGCTGGAACGTATCCAGGATTTTCTGATGCACGAATACCATATTGCGCACGCTACGATTCAGATGGAGTATCAAGTGT
GTCACGGCCCGGACTGTCATCTGAATCAGACGCCATCCGGGCATGTTCATCACCATTAA

Upstream 100 bases:

>100_bases
AGTCTGATAACGGGAGAGCTTTCGCTCTCCTTTTTATTTTGTCAGCGAAAAATCAGTATGATGTCTACAGTATTGATGAG
AATAACAAAGGAATGACGTT

Downstream 100 bases:

>100_bases
CGGGAAAGCGCGCGCGATCCTCGCTCCCGCGCGCTGTTTATCCACAGGCGGCTACCGTTCACGGCGATAAATGTCAGGAT
CAGATATTCCAGCGACATCG

Product: zinc transporter ZitB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTVRHT
FGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVAGNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHV
MGDLLGSVGAIVAALIIIWTGWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVH
HVHVWMVGEKPIMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQVCHGPDCHLNQTPSGHVHHH

Sequences:

>Translated_312_residues
MAHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTVRHT
FGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVAGNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHV
MGDLLGSVGAIVAALIIIWTGWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVH
HVHVWMVGEKPIMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQVCHGPDCHLNQTPSGHVHHH
>Mature_311_residues
AHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTVRHTF
GWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVAGNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHVM
GDLLGSVGAIVAALIIIWTGWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVHH
VHVWMVGEKPIMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQVCHGPDCHLNQTPSGHVHHH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=320, Percent_Identity=32.8125, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI289803013, Length=323, Percent_Identity=32.1981424148607, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289803009, Length=323, Percent_Identity=32.1981424148607, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289803007, Length=323, Percent_Identity=32.1981424148607, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289803003, Length=323, Percent_Identity=32.1981424148607, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI64762489, Length=323, Percent_Identity=32.1981424148607, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI21359890, Length=300, Percent_Identity=31, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI21361112, Length=320, Percent_Identity=30.3125, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI20070323, Length=345, Percent_Identity=24.3478260869565, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI14210520, Length=231, Percent_Identity=29.004329004329, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI52352803, Length=129, Percent_Identity=43.4108527131783, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI52351208, Length=162, Percent_Identity=30.8641975308642, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=28.6821705426357, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=28.6821705426357, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786966, Length=296, Percent_Identity=85.8108108108108, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1790349, Length=191, Percent_Identity=27.2251308900524, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193210990, Length=328, Percent_Identity=32.9268292682927, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17555794, Length=326, Percent_Identity=32.8220858895706, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17555796, Length=325, Percent_Identity=31.6923076923077, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI32564488, Length=317, Percent_Identity=29.9684542586751, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17550440, Length=126, Percent_Identity=34.9206349206349, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17550442, Length=126, Percent_Identity=34.9206349206349, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=181, Percent_Identity=36.4640883977901, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323899, Length=132, Percent_Identity=37.1212121212121, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324892, Length=121, Percent_Identity=38.0165289256198, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656728, Length=346, Percent_Identity=30.3468208092486, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24656724, Length=346, Percent_Identity=30.3468208092486, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24656720, Length=346, Percent_Identity=30.3468208092486, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24656715, Length=346, Percent_Identity=30.3468208092486, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21357035, Length=346, Percent_Identity=30.3468208092486, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24583858, Length=333, Percent_Identity=28.8288288288288, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24584409, Length=136, Percent_Identity=36.7647058823529, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28574430, Length=136, Percent_Identity=36.7647058823529, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=31.9727891156463, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=31.9727891156463, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=31.9727891156463, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=31.9727891156463, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24645863, Length=127, Percent_Identity=32.2834645669291, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34486; Mature: 34355

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00511 CRF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAA
CCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
LLFALLAVQFSRRPPTVRHTFGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHVMGDLLGSVGAIVAALIIIWT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCHHHHCCE
HVHVWMVGEKPIMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQVCHGPDCH
EEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCC
LNQTPSGHVHHH
CCCCCCCCCCCC
>Mature Secondary Structure 
AHSHSHADSHLPKDNNARRLLFAFIVTAGFMLLEVVGGILSGSLALLADAGHMLTDAAA
CCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
LLFALLAVQFSRRPPTVRHTFGWLRLTTLAAFVNAIALVVITLLIVWEAIERFYTPRPVA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNLMMVIAVAGLLANLFAFWILHRGSDEKNLNVRAAALHVMGDLLGSVGAIVAALIIIWT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GWTPADPILSILVSVLVLRSAWRLLKDSVNELLEGAPVSLDINALQRHLSREIPEVRNVH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCHHHHCCE
HVHVWMVGEKPIMTLHAQVIPPHDHDALLERIQDFLMHEYHIAHATIQMEYQVCHGPDCH
EEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCC
LNQTPSGHVHHH
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]